Comment on the Adiabatic Condition

The experimental observation of effects due to Berry's phase in quantum systems is certainly one of the most impressive demonstrations of the correctness of the superposition principle in quantum mechanics. Since Berry's original paper in 1984, the spin 1/2 coupled with rotating external magnetic field has been one of the most studied models where those phases appear. We also consider a special case of this soluble model. A detailed analysis of the coupled differential equations and comparison with exact results teach us why the usual procedure (of neglecting nondiagonal terms) is mathematically sound.Comment: 9 page

Berry's phase in the two-level model

We study the adiabatic evolution of a two-level model in the presence of an external classical electric field. The coupling between the quantum model and the classical field is taken in the electric dipole approximation. In this regime, we show the absence of geometric phases in the interacting two-level model in the presence of any periodic real time-dependent classical electric field. We obtain a conservative scalar potential in the calculation of Berry's phases of the instantaneous eigenstates of the model. For complex electric fields, we recover the existence of geometric phases. In particular, the geometric phases of the instantaneous eigenstates of the model in the presence of a positive or of a negative frequency component of the monochromatic electric field differ by an overall sign. As a check on our results, we map this interacting two-level model onto a spin-1/2 model under the action of a classical magnetic field. We confirm that the first one acquires Berry's phase only in the rotating wave approximation [RWA].Comment: 11 pages, no figur

Milk as a drug delivery platform in paediatrics

Communication presented at the PSSRC − 9th Annual Symposium. 16-18 September 2015, Ghent, Belgium"Purpose: to assess the physical properties of spray dried milk powders and evaluate drug-milk interactions.

Medicinal powders made of fresh milk for pediatric use

Communication presented at the 1st International Congress of CiiEM - From Basic Sciences to Clinical Research. 27-28 November 2015, Egas Moniz, Caparica, Portugal"Nowadays, the need to formulate medicines specifically designed for children is imperative [1] and solid dosage forms are the first choice for providing the required drug stability and dose accuracy. Milk, as a worldwide accepted food, is proposed in this study as a platform to deliver drugs orally in pediatrics. Therefore, the main goals of this project are: (a) to assess the properties of spray-dried milk powders, (b) to evaluate drug-milk interactions and (c) to ascertain the stability of the spray-dried milk powders."Fundação para a Ciência e a Tecnologi

A familial partial AZFb-c microdeletion associated with diferente fértile phenotypes

After the Klinefelter syndrome, Y chromosome microdeletions are the second most frequent genetic cause of spermatogenic failure resulting in male infertility. Y chromosome microdeletions, encompassing one or more of the three AZF regions, are associated with diverse testicular histology, ranging from Sertoli-cell-only syndrome (AZFa del), maturation arrest (AZFb del) to hypospermatogenesis (AZFc del). The molecular screening of these regions is routinely performed in the work-up of infertile patients with azoospermia or severe oligozoospermia as each one has different prognostic values, both in terms of clinical decision-making and appropriate genetic counselling as well as for understanding the etiology of spermatogenesis impairment. Different partial AZFc deletions were already described, although it is still controversial if these are truly a genetic risk factor for spermatogenesis impairment or a deletional variant without phenotypic consequences. Here we present the molecular results obtained after AZF analysis of two infertile brothers (both diagnosed with oligoteratoastenozoospermia), and of their fertile father. Several multiplex-PCR assays were performed with distinct sets of STS markers, specific for the three AZF regions. The molecular analysis revealed that all three men presented the same partial AZFb/c microdeletion, namely the absence of the sY1197, sY1291 and sY1192 STSs. This microdeletion probably results from the recombination of amplicons b1/b3, reducing the gene copy number of PRY, BPY, DAZ, and RBMY. The b1/b3 deletion is rare and its influence on spermatogenesis is still not clear since it can be found in men with severe oligozoospermia or with normal sperm counts. Our result suggests that b1/b3 del is most likely a risk factor predisposing to spermatogenic failure, but is not sufficient alone. The different (in)fertile phenotypes associated with it, a fertile father opposed to his two infertile sons, can be possibly influenced by genetic background, environmental and epigenetic factors, contributing to different phenotypic expressions of individual/specific genomes

Spray-dried fresh milk powders for oral drug delivery in pediatrics

Poster presented at the 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 4-7 April 2016, Glasgow, UKN/

Imaginary Phases in Two-Level Model with Spontaneous Decay

We study a two-level model coupled to the electromagnetic vacuum and to an external classic electric field with fixed frequency. The amplitude of the external electric field is supposed to vary very slow in time. Garrison and Wright [{\it Phys. Lett.} {\bf A128} (1988) 177] used the non-hermitian Hamiltonian approach to study the adiabatic limit of this model and obtained that the probability of this two-level system to be in its upper level has an imaginary geometric phase. Using the master equation for describing the time evolution of the two-level system we obtain that the imaginary phase due to dissipative effects is time dependent, in opposition to Garrison and Wright result. The present results show that the non-hermitian hamiltonian method should not be used to discuss the nature of the imaginary phases in open systems.Comment: 11 pages, new version, to appear in J. Phys.

Caracterização genética de um teste de progênies de Pinus taeda visando à produção de madeira.

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