Neurofibromatosis Associated With Hyper Parathyroidism

A case involving the rare occurance of hyperparathyroidism in association with neurofibromatosis"nis reported."nRadiographic findings revealed multiple radiolucency which diagnosed as giant cell lesions. Also, high levels"nof PTH and alkalan phosphatase were found from repeated measurements of the serum."nNeurofibromatosis associated with hyperparathyroidism diagnosed in this case report

Evaluation of Chromosomal Disorders in Tissue and Blood Samples in Patients with Oral Squamous Cell Carcinoma

Statement of Problem: Many studies have indicated that genetic disturbances are common findings in patients with Oral Squamous Cell Carcinoma (OSCC). Identification of these changes can be helpful in diagnostic procedures of these tumors.Purpose: The aim of this study was to appraise the chromosomal disorders in blood and tissue patients with OSCC.Methods and Materials: In this descriptive study, the study group consisted of all OSCC patients who were referred to the Faculty of Dentistry, Tehran University of Medical Sciences, Maxillofacial Surgery Clinic of Shariati Hospital, and Amir Aalam Hospital fromSeptember 2000 to November 2002. In order to study chromosomal disorders in the peripheral blood lymphocytes, 5 mL of blood was obtained from each patient In patients with the large lesion, a piece of involved tissue were obtained and cultured for 24 hours.This led to 29 blood samples and 16 tissue specimens and any relation between OSCC and age, sex, smoking and alcohol use were evaluated.Results: In this study, OSCC was more common in males than in females (3 to 5). 31% of our patients were smokers, and one had a history of alcoholic consumption. There was an increase in incidence of OSCC with age. In this study, all patients had numerical(aneuploidy, polyploidy) and structural chromosomal disorders (double minute, fragment,breakage and dicentric). There was significant difference between blood and tissue chromosomal disorders (aneuploidy, polyploidy,breakage) in OSCC patients.Conclusion: It can be concluded that chromosomes in patients with OSCC might show some genetic aberration and evaluation of involved tissue might be better way for determining this disorders

Evaluating thrombophilia in severe ovarian hyperstimulation syndrome

Background: Ovarian hyper stimulation syndrome (OHSS) and its consequences, especially thromboembolic events, are of the most dangerous complications of assisted reproductive technologies (ART). It is unclear whether a thrombophilic predisposition or changes in blood components during clinical presentation of OHSS increase thrombotic risks. Testing for certain thrombophilias in selected high risk patients may help risk assessment and decision-making about prophylactic measures. Methods: In this study carried out in April 2010 to March 2011, 108 in vitro fertilization candidates with ≥20 follicles following ovarian stimulation were recruited. Protein S, protein C, antithrombin, lupus anticoagulant and anticardiolipin antibodies were measured. Blood tests were compared between severe and non-severe OHSS groups and their changes were traced after onset of clinical OHSS in 43 patients presenting with severe symptoms by repeating the tests at hospital admission. Results: Mean protein S activity was lower in severe OHSS group (101.7±16.3 vs. 118.4±17.0 P<0.001). After clinical presentation of severe OHSS, this level decreased to 91.6±20.1 (P<0.001). Antithrombin levels decreased 2.09% after the onset of symptoms in the group with severe OHSS, but this difference was not statistically significant (P=0.051). Protein C, lupus anticoagulant and anticardiolipin antibodies were not correlated to severe OHSS development. Conclusion: Patients with relatively lower protein S activity were at higher risk for the development of severe OHSS, and its dangerous consequences. During clinical OHSS presentation, protein S decreased even more, and patients were more vulnerable to hypercoagulability states. These points should be kept in mind in risk assessment and adoption of prophylactic strategies

Carbapenemase-producing Klebsiella pneumoniae strains among clinical specimens in Kashan (2014-2015)

Background: Resistance among the Enterobacteriaceae family especially in Klebsiella genus as one important leading cause of nosocomial infection, is one of the most important health challenges all over the world. Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are among the most prevalent &beta;-lactamases in Klebsiella strains. Our aim was to study KPC-producing Klebsiella strains in clinical samples in Kashan. Materials and Methods: In this cross-sectional study Klebsiella isolates (n=181) were recovered from clinical samples during September to July 2015. After identification of Klebsiella isolates by biochemical tests, the susceptibility pattern of recovered Klebsiella from clinical isolates to 17 antibiotics were studied by disk diffusion method. Using PCR assay blaKPC gene in Klebsiella isolates were studied. Statistical analyses of data were performed by Chi square test and (P&lt;0.05) was considered statistically significant. Results: Forty eight out of 181 Klebsiella samples were multidrug resistant and the most resistant was seen to Ampicillin and Cephalotin. Among the Klebsiella isolates, 21(11.6) carried blaKPC gene which most of them were recovered in ICU ward from urinary and respiratory specimens. Conclusions: Our study showed that in Klebsiella strains isolated from patients, especially hospitalized patients in Kashan, resistance to carbapenems is seen with presence of blaKPC gene. Due to the ability of gene to spread by mobile genetic elements the finding is alarming in treatment of Klebsiella infections

Depression and infertility: evaluation of 681 infertile women using Beck depression inventory

Introduction: Infertility and depression are major problems of today&apos;s societies. Although depression is one of the most prevalent diseases in primary care practice, consult for receiving help is carried out much less than true prevalence of the disease. Therefore gathering information about prevalence and risk factors of depression is very valuable. Beck Depression Inventory (BDI) which is a screening tool for depression can be used in Iranian patients because of availability of a validated translation. The objective of this study was to estimate the prevalence of depression in infertile subjects in an infertility center. Materials and Methods: In this study, 681 infertile women were evaluated in Shariati Hospital, Tehran. Demographic information’s including age, duration, type and cause of infertility, level of education, previous treatments and smoking habits were recorded. BDI was completed by patients and score was estimated. Score of 16 and higher was assumed positive. Results: There was no relationship between age and prevalence of positive BDI score, but prevalence of positive BDI score was higher in infertilities of longer duration, infertilities caused by both male and female factors and in patients with low level of education and history of previous treatment or surgical therapy. Conclusion: Infertile patients are at risk of depression. Rate of consulting with psychiatrists and getting help is low in our country due to cultural aspects, so screening of high risk subgroups in infertile patients and referring them to psychiatrist would be very helpful

Salivary oxidative stress in oral lichen planus treated with triamcinolone mouthrinse

Background: Total antioxidant capacity (TAC) and malondialdehyde (MDA) levels have not been reported in oral lichen planus (OLP) patients treated with a topical corticosteroid. This study evaluates TAC and MDA levels in unstimulated saliva of OLP patients. Such measurements may need to be supported by clinical observation. Materials and Methods: Twenty patients with OLP participated in a study conducted at the Department of Oral Medicine, Tehran University of Medical Sciences. Salivary TAC and MDA were determined by biochemical analyses before and after 5-week triamcinolone acetonide (0.2) mouthrinse treatment. Subjective symptoms as well as lesion status pre- A nd post-treatment were measured using visual analog scale (VAS) and clinical scoring system, respectively. Wilcoxon signed rank test was used for the evaluation of MDA and TAC parameters, VASs, and rates of clinical scores. Spearman's rank correlation was used to determine the relationship between different variables. Results: A statistically significant increase in salivary TAC was found after treatment. There was no significant difference in the reduction of salivary MDA levels in OLP patients after treatment. Conclusion: Posttreatment analyses revealed a significant degree of recovery and pain relief of OLP lesions. Hence, triamcinolon mouthrinse by reducing oxidative stress is an appropriate treatment in OLP patients. © 2017 Dental Research Journal