2 research outputs found
African Polyherbal Formulation Possesses Chemopreventive and Chemotherapeutic Effects on Benzene- Induced Leukemia in Wistar Rats
Background: Chemotherapy and radiotherapy are effective cancer treatment options but they are
accompanied by serious side effects and complications such as systemic cytotoxicity, chemo- or
radio-resistance. Therefore, more effective therapies are sorely needed. This study investigated the
chemopreventive and chemotherapeutic effects of a polyherbal formulation on benzene induced leukemia in Wistar rats. The polyherbal formulation is composed of fruits such as Orange, Lime,
Lemon, Pineapple, Grape and Vegetables like; Pumpkin leave, Garden egg suspended in honey
medium.
Methods: Leukemia was induced by injecting 0.2 ml of benzene solution intravenously through the
tail of young rats at 48 h intervals for four times. Leukemia developed in 92% of rats some weeks
after the last benzene injection and following up weekly observation for leukemia development in
appropriate rat groups. Leukemia burden was assessed using indicator parameters such as total
leukocyte, red blood cell count, hematocrit, and hemoglobin concentration. Exactly 0.48 ml of the
polyherbal formulation was administered orally by gavage using oral cannular once daily post
leukemia induction for four weeks.
Results: Leukemia induction reflected in significant reduction in hematocrit, hemoglobin
concentration, red cell count and a marked and a significant increase in leukocyte count over the
control (p < 0.05). There is significant difference between the chemopreventive group and
chemotherapeutic (leukemia positive group treated with poly-herbal formulation) and the leukemia
positive control group untreated.
Conclusion: This study reveals profound activity of the poly-herbal formulation at preventing and
reversing experimentally developed leukemia in the rat groups, hence the ability of the polyherbal
formulation in alleviating the cancer symptom
African Polyherbal Formulation Possesses Chemopreventive and Chemotherapeutic Effects on Benzene - Induced Leu kemia in Wistar Rats
Chemotherapy and radiotherapy are effective cancer treatment options but they are
accompanied by serious side effects and complications such as systemic cytotoxicity, chemo
-
or
radio
-
resistance. Therefore, more effective therapies are sorely
needed. This study investigated the
chemopreventive and chemotherapeutic effects of a polyherbal formulation on benzene
induced eukemia in Wistar rats. The polyherbal formulation is composed of fruits such as Orange, Lime,
Lemon, Pineapple, Grape and Vege
tables like; Pumpkin leave, Garden egg suspended in honey
medium.
Method
s
:
Leukemia was induced by injecting 0.2 ml of benzene solution intravenously through the
tail of young rats at 48 h intervals for four times. Leukemia developed in 92% of rats some w
eeks
after the last benzene injection and following up weekly observation for leukemia development in
appropriate rat groups. Leukemia burden was assessed using indicator parameters such as total
leukocyte, red blood cell count, hematocrit, and hemoglobin
concentration. Exactly 0.48 ml of the
polyherbal formulation was administered orally by gavage using oral cannular once daily post
leukemia induction for four weeks.
Results:
Leukemia induction reflected in significant reduction in hematocrit, hemoglobin
concentration, red cell count and a marked and a significant increase in leukocyte count over the
control (p < 0.05). There is significant difference between the chemopreventive group and
chemotherapeutic (leukemia positive group treated with poly
-
herbal f
ormulation) and the leukemia
positive control group untreated.
Conclusion:
This study reveals profound activity of the poly
-
herbal formulation at preventing and
reversing experimentally developed leukemia in the rat groups, hence the ability of the polyhe
rbal
formulation in alleviating the cancer symptom