Investigation of oxidative stress parameters and hormone levels in men with suspected infertility

Aim: It was suggested that oxidative stress (OS) is one of the major causes for male infertility. Therefore, the purpose of this study was to evaluate the OS parameters and some hormone levels in men with suspected infertility. Methods: A total of 100 males was included in the study. Study groups were designed as 5 groups of normozoospermia (n=20), azoospermia (n: 20), oligozoospermia (n=20), oligo-asthenozoospermia (n=20), idiopatic infertility (n:20) according to sperm parameters and etiology. Sperm parameters and OS markers including plasma total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), 8 Hydroxy 2 deoxy Guanosine (8-OHdG)  were evaluated in all groups. In addition, FSH, LH, total testosterone, TSH, prolactin, estradiol, folic acid, Vitamin B12 and Vitamin D were analyzed. Results: TAC was the lowest in azoospermia group compared to other groups while the highest TAC was in normozoospermia group (p=0.002). Total FSH and LH levels were higher in azoospermia group compared to other groups. Conclusions:  As far as we know, this is the first study evaluating OS markers and hormones in men with suspected infertility. Our results show that the OS is increased in men with azoospermia compared to other groups

The Effect Of Air Temperature On Quality Of Sperm In Diyarbakir: An Analysis Over Six Years

INTRODUCTION: There are many studies focusing on the effect of environmental conditions on human sperm quality. Therefore, we aimed to evaluate the possible effects of environmental factors such as air temperature and humidity, sun exposure time and particulate matter 10 (PM10), on semen parameters in Diyarbakır. METHODS: In this study, semen analysis data obtained from 7318 men with suspected infertility were analyzed retrospectively. Since spermatogenesis takes more than two months, retrospective data were adjusted to assess environmental exposure three months before semen retrieval. Semen samples taken from the participants were examined in conformity with WHO criteria after liquefaction. RESULTS: The mean age was 30.67+- 7.21 years. The average air temperature was inversely related to sperm concentration, total sperm count, and total progressive motile sperm count (TPMSC). Sperm concentration, total sperm count, and TPMSC increased at low temperature (< 15oC) compared to high temperature (>15oC). TPMSC was higher in sun exposure for less than 8 hours than those exposed for more than 8 hours. Also, sperm concentration, and total sperm count, were higher when above relative humidity 50% than below 50% relative humidity. There was no significant difference between PM10 values (<40 μg/m3 and ˃40 μg/m3) and sperm parameters. DISCUSSION AND CONCLUSION: Our results supported that environmental factors such as sun exposure, relative humidity and air temperature negatively affect sperm parameter

Effects of COVID-19 on sexual health in men with suspected infertility using semen analysis and serum hormone profile: A single-center experience

Aim: To evaluate the effect of COVID-19 on sex hormone levels between men who have recovered from COVID-19 infection and men who have never been infected. Method: This study included 80 men who applied to the Infertility Clinic with a diagnosis of primary or secondary infertility. Semen analysis was performed twice, before COVID-19 and after the treatment of COVID-19 disease. In addition, Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), testosterone (T), and 17β- estradiol (E2) levels were compared between the men after COVID-19 disease and uninfected men. Results: There was a significant difference in progressive sperm motility and immobility before and after the COVID-19 disease. Progressive sperm motility was decreased after COVID-19 disease while immobility was increased after COVID-19. The serum T level was lower and the E2 level was higher in men after COVID-19 disease compared to uninfected men. Conclusions: COVID-19 may adversely affect gonadal functions by causing to more deterioration of the hormone levels and semen parameters in infertile males. Therefore, gonadal function evaluation, including semen and sex-related hormones examination, is required to follow up the male COVID-19 patients with a reproductive plan