Anatomical distribution and demographic data of gastric cancer in Mashhad, Iran

Introduction: The global incidence of gastric cancer (GC) has been decreased dramatically in recent decades and characteristics of this cancer has been changed. Most of these changes can be resulted from changes in dietary and nutritional habits. This cancer is the most common cancer in north and northeast of Iran. In present report we will briefly summaries the gastric tumor location in a population from north east of Iran. Methods: We have evaluated the stomach tumors location according to patient’s gender and age. Among 212 Iranian patients who were lived in Mashhad, Iran, the cardia was the most common involved anatomic location. There wasn’t any significant relation between patient gender and tumor location as well as patient age and tumor location. Results: According to our results, the incidence of gastric cancer in patients who are aged between 60 to 69 years is decreasing in our population while the most common anatomic site of tumor remains the same. Conclusion: By knowing the most prevalent tumor site and related risk factors, more precise diagnostic and preventing programs can be established. Increasing global awareness about the risk factors of GC seems to be the main reason and efforts should be made to speed up this issue

Personalized peptide-based vaccination for treatment of colorectal cancer: rational and progress

Colorectal cancer (CRC) is one of the most common cancers globally and is associated with a high rate of morbidity and mortality. A large proportion of patients with early stage CRC who undergo conventional treatments develop local recurrence or distant metastasis and in this group of advanced disease, the survival rate is low. Furthermore there is often a poor response and/or toxicity associated with chemotherapy and chemo-resistance may limit continuing conventional treatment alone. Choosing novel and targeted therapeutic approaches based on clinicopathological and molecular features of tumors in combination with conventional therapeutic approach could be used to eradicate residual micrometastasis and therefore improve patient prognosis and also be used preventively. Peptide-based vaccination therapy is one class of cancer treatment that could be used to induce tumor-specific immune responses, through the recognition of specific antigen-derived peptides in tumor cells, and this has emerged as a promising anti-cancer therapeutic strategy. The aim of this review was to summarize the main findings of recent studies in exciting field of peptide-based vaccination therapy in CRC patients as a novel therapeutic approach in treatment of CRC

Assessment of prognostic factors and treatment results in Breast cancer patients who referred to Reza Radiation Oncology Center in a 5-year period (2007-2012)

Introduction: According to recent epidemiologic studies, the prevalence of breast cancer is growing in our country and becoming a great concern for related researchers. While different studies in different regions and population reported variable prognostic factors for breast cancer, this study aimed to evaluate effective factors for breast cancer survival in an oncology center of Mashhad city in a five-year period. Material and methods: Medical and demographic information of all female breast cancer patients who were referred to Reza Radiation Oncology Center of Mashhad city between 1386 to1390 were used in this cross sectional study and the effect of different variables on their survival was evaluated. Survival analysis and cox regression tests were used in this study and confidence interval of 0.05 was considered. Results: Mean age of participants’ was 48 years. Mean overall survival of patients younger than 48 years of age was 51.96 months and 52.93 for those who were older. There was not any significant difference between these two groups (P=0,336). Cancer stage and estrogen receptor presentation were two main factors affecting patients overall survival in this study. Conclusion: In present study, survival rates of breast cancer is favorable in contrast to other similar studies and screening of mentioned effective factors on survival in peak age of breast cancer diagnosis is suggested. Keywords: Breast neoplasm; prognosis; surviva