Force transmission across a core-sheath interface in peripheral nerves [poster presentation]

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Investigating the mechanical behaviour at a core-sheath interface in peripheral nerves

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Health Problems Among Adolescent Boys and Girls in Secondary Schools in Obollo-Afor Education Zone of Enugu State, Nigeria

The cross-sectional survey was utilized to determine the health problems among adolescent boys and girls in secondary schools in Obollo-Afor education zone of Enugu state. Employing the Statistical Package for Social Sciences (SPSS), 1463 self-completed copies of questionnaire (98.3% of those distributed) were used for data analysis, using percentages and chi-square (p < .05). Results showed that boys reported higher rates of skin rashes, accidents and sexually transmitted diseases than did girls. Significant differences were found in skin rashes, malaria, eye defects, respiratory track diseases, accidents, mouth odour, abdominal pain and sexually transmitted diseases. With regard to mental health problems, girls reported higher rates of most of symptoms than did boys. Significant differences (p < .05) were found in fear, forgetfulness, fatigue and stress. In social health problems, boys reported higher rates in most of the symptoms than girls. Significant differences were found in lack of finance, frequent punishment, hatred by others, smoking, rape, violence and secret cult activities. It is recommended that interventions that could help students avoid health-risk behaviour should be initiated. Keywords: health problems, adolescent, boys and girls, secondary schools

Perceived Benefits of Prenatal Exercise Among Pregnant Women Attending Antenatal Clinic at Federal Teaching Hospital, Abakaliki, Nigeria

This paper investigated the perceived benefits of prenatal exercise among pregnant women attending antenatal clinic at Federal Teaching Hospital Abakaliki, Ebonyi State. One research question and two hypotheses guided the study. Descriptive survey design was used, the population of the study was 7200 pregnant women while the sample for the study was 720 pregnant women attending antenatal clinic at Federal Hospital Abakaliki, Ebonyi State. A self-developed structured questionnaire was used as instrument for data collection. Mean and standard deviation was used to answer research question while ANOVA statistics were used to test the hypotheses at 0.05 level of significant. The study found that pregnant women attending antenatal clinic at Federal Teaching Hospital Abakaliki, Ebonyi State had positive perception on the benefit of prenatal exercise and that there are significant differences on the perception of benefit of prenatal exercise among pregnant women attending antenatal clinic at Federal Teaching Hospital Abakaliki, Ebonyi State based on age and level of education. It was recommended that Government, health educators and hospital management should organize continuing education programmes, seminars and workshop to promote prenatal exercise among pregnant women to actualize the perceived benefits of prenatal exercise in pregnancy. Keywords: Exercise, prenatal exercise, pregnant woman, perceived benefit

3D culture model of fibroblast-mediated collagen creep to identify abnormal cell behaviour

Native collagen gels are important biomimetic cell support scaffolds, and a plastic compression process can now be used to rapidly remove fluid to any required collagen density, producing strong 3D tissue-like models. This study aimed to measure the mechanical creep properties of such scaffolds and to quantify any enhanced creep occurring in the presence of cells (cell-mediated creep). The test rig developed applies constant creep tension during culture and measures real-time extension due to cell action. This was used to model extracellular matrix creep, implicated in the transversalis fascia (TF) in inguinal hernia. Experiments showed that at an applied tension equivalent to 15% break strength, cell-mediated creep over 24-h culture periods was identified at creep rates of 0.46 and 0.38%/h for normal TF and human dermal fibroblasts, respectively. However, hernia TF fibroblasts produced negligible cell-mediated creep levels under the same conditions. Raising the cell culture temperature from 4 to 37 ◦C was used to demonstrate live cell dependence of this creep. This represents the first in vitro demonstration of TF cell-mediated collagen creep and to our knowledge the first demonstration of a functional, herniarelated cell abnormality

KNOWLEDGE OF PHYSICAL ACTIVITY WITH BLOOD PRESSURE DISTRIBUTION AND DEMOGRAPHIC CHARACTERISTICS AMONG SECONDARY SCHOOL ADOLESCENTS IN EBONYI STATE, NIGERIA

This study determined the knowledge of physical activity on blood pressure distribution among Secondary School Students in Ikwo Local Government Area of Ebonyi State. A cross-sectional survey was employed for this study. Five research questions and 5 hypotheses guided the study. The instrument used for the study was validated by three experienced lecturers. The population for this study consisted of all secondary students in the area. Multi-stage sampling technique was used to select 264 senior secondary students from 6 schools as they were properly guided on the complete filing and return of the questionnaires titled, Physical Activity and Blood Pressure Questionnaire, (PABPQ). The reliability coefficient value obtained was r=0.763. Two hundred and sixty-four questionnaires were administered and had a return rate of 95%. Data obtained were analyzed using frequency and percentages to answer research questions and chi-square to test research hypotheses at .05 alpha levels. The findings of the study showed a high level of knowledge of physical activity on blood pressure among respondents. Also, knowledge of physical activity on blood pressure distribution based on class, age and gender of the students were indicated to be high. Based on the findings, it was thus recommended amongst others that there should be the inclusion of the practical aspect of physical activity into the school system, as more suitable physical activities should be taught at all levels of learning. Nevertheless, there is a need to put into practice this knowledge gained for optimal and healthy living.  Article visualizations

Psychological complications of childhood chronic physical illness in Nigerian children and their mothers: the implication for developing pediatric liaison services

<p>Abstract</p> <p>Background</p> <p>Pediatric liaison services attending to the psychological health needs of children with chronic physical illness are limited or virtually non-existent in Nigeria and most sub-Saharan African countries, and psychological problems complicate chronic physical illness in these children and their mothers. There exist needs to bring into focus the public health importance of developing liaison services to meet the psychological health needs of children who suffer from chronic physical illness in this environment. Sickle cell disease (SCD) and juvenile diabetes mellitus (JDM) are among the most common chronic physical health conditions in Nigerian children. This study compared the prevalence and pattern of emotional disorders and suicidal behavior among Nigerian children with SCD, JDM and a group of healthy children. Psychological distress in the mothers of these children that suffer chronic physical illness was also compared with psychological distress in mothers of healthy control children.</p> <p>Methods</p> <p>Forty-five children aged 9 to 17 years were selected for each group of SCD, JDM and controls. The SCD and JDM groups were selected by consecutive clinic attendance and the healthy children who met the inclusion criteria were selected from neighboring schools. The Youth version of the Computerized Diagnostic Interview Schedule for Children, version IV (C- DISC- IV) was used to assess for diagnosis of emotional disorders in these children. Twelve-item General Health Questionnaire (GHQ – 12) was used to assess for psychological distress in mothers of these children and healthy control children.</p> <p>Results</p> <p>Children with JDM were significantly more likely to experience DSM – IV emotional disorders than children with SCD and the healthy group (p = 0.005), while children with JDM and SCD were more likely to have 'intermediate diagnoses' of emotional disorders (p = 0.0024). Children with SCD and JDM had higher rates of suicidal ideation when compared to healthy control children and a higher prevalence of maternal psychological distress was found in their mothers when compared to the mothers of healthy children (p = 0.035).</p> <p>Conclusion</p> <p>The higher prevalence of emotional disorders and suicidal ideation among children with SCD and JDM points to a need for development of liaison services in pediatric facilities caring for children with chronic physical illness to ensure holistic approach to their care. The proposed liaison services would also be able to provide family support interventions that would address the psychological distress experienced by the mothers of these children.</p

Individual and partnership characteristics associated with consistent condom use in a cohort of cisgender men who have sex with men and transgender women in Nigeria

This study reports on the individual and partnership characteristics that influence consistent condom use in cisgender men who have sex with men (MSM) and transgender women (TGW) attending trusted community centers that provide HIV prevention and treatment services in Nigeria. Adults assigned male at birth who reported anal sex with male partners who enrolled between March 2013–2019 and had information about at least one male sexual partner were included in these analyses. At enrollment and follow-up visits every 3 months for up to 18 months, participants were administered detailed questionnaires that collected information about demographics, sexual practices, HIV risk behaviors, and characteristics and behaviors of their partners in the previous year (at enrollment) or the preceding 3 to 6-months (at follow-up visits). Logistic regression models with generalized estimating equations were used to assess the odds ratio (OR) and 95% confidence intervals (CI) of individual, partner, and partnership characteristics associated with consistent condom use (CCU). A participant was defined as consistently using condom if they reported always using condoms all the time they had insertive, receptive or both types of anal sex with a male partner. At the individual level, CCU was positively associated with higher education, disclosure of key population status to a healthcare worker and negatively associated with poor access to condoms. At the partner and partnership level, CCU was associated with partners with higher education (aOR: 1.36; 95% CI: 1.07–1.72), casual relationships (aOR: 1.22; 95% CI: 1.11–1.34) and relationships in which partners encouraged the participant to use condoms with other partners (aOR: 1.14; 95% CI: 1.02–1.28). Relationships in which the partner was married to a woman and/or the partner’s HIV status positive or unknown were negatively associated with CCU. These findings suggest that individuals in relationships where partners were more open and encouraged safer sex were more likely to consistently use condoms. HIV prevention programs should consider leveraging communication to sexual partners to encourage condom use as this may support condom use with other sexual partners. Given sustained and growing HIV and STI epidemics among MSM and TGW, even with pre-exposure prophylaxis scale-up, it is crucial to continue to study optimal implementation strategies to increase condom use.https://doi.org/10.1186/s12889-021-11275-

Investigating the mechanical shear-plane between core and sheath elements of peripheral nerves

The mechanical architecture of rat sciatic nerve has been described as a central core surrounded by a sheath, although the way in which these structures contribute to the overall mechanical properties of the nerve is unknown. We have studied the retraction responses of the core and sheath following transection, together with their tensile properties and the interface between them. Nerves were harvested and maintained at their in situ tension and then either transected entirely, through the sheath only, or through an exposed section of the core. The retraction of each component was measured within 5 min and again after 45 min. Post mortem loss of retraction was tested 0 min or 60 min after excision. For fresh nerves, immediate retraction was 12.68% (whole nerve), 5.35% (sheath) and 4% (core), with a total retraction of 15%, 7.21% and 5.26% respectively. For stored nerves, immediate retraction was 5.33% (whole nerve) and 5.87% (sheath), with an extension of 0.78% for core, and a total retraction of 6.71% and 7.87% and an extension of 1.74%, respectively. Tensile extension and pullout force profiles were obtained for the sheath, the core and the interface between them. These showed a consistent hierarchy of break strengths that would, under increasing load, result in failure of the interface, then the core and finally the sheath. These data reflect the contributions of material tension and fluid swelling pressure to total retraction, and the involvement of an energy-dependent process that runs down rapidly post mortem. This study increases our understanding of the composite nature of peripheral nerve tissue architecture and quantifies the material properties of the distinct elements that contribute to overall mechanical function