STUDY REGARDIND THE ROLES OF HUMAN BETA-DEFENSIN 3 IN MONITORING OF PERI-IMPLANTITIS

Aim of the study Our study objective was to identify a possible association between the hBD-3 level from peri implant crevicular fluid and clinical status in post dental implant patients. Material and methods In this study we comprised 16 patients with dental implants that were examined after 7 and 21 days since dental implant installation and were included in our study based on probing depth (PD) and bleeding on probing (BOP) measurements as follows: 12 subjects with healthy implants and 4 patients with peri-implantitis. The periimplantar crevicular fluid samples were collected by using sterile paper points and the levels of hBD-3 were assayed by using an ELISA kit. Results Our study results show that there are highly significant statistically differences regarding the value of peri-implantar pocket depth between healthy and peri-implantitis patients evaluated after 7 and 21 days after insertion of dental implants (p<0.0001). Also, we obtained highly significant statistically differences regarding the hBD-3 values between healthy and peri-implantitis patients evaluated after 7 and 21 days after insertion of dental implants (p<0.0001). The study results show that there is a high inverse correlation between peri-implantar pocket depth and hBD-3 value in peri-implantitis patients evaluated after 7 days (r=-0.904) and a moderate positive correlation to the same patients evaluated after 21 days (r=0.400). Conclusions Within the limit of the study group, we can conclude that hBD-3 quantified in peri-implant crevicular fluid can be used as a biomarker in post-implant patient assessment and in peri-implantitis diagnosis