Formación del Semillero de Derechos Humanos e investigación sobre memoria, verdad y justicia

This article covers two aspects that are divided into the formation of the Human Rights Seedbed of the Faculty of Law of the American University (Semillero), as well as in the decision and execution of starting a research project after the visits of two museums: Museum of Memories and Museum of Justice, both related to human rights violations during the dictatorship of Alfredo Stroessner. In this context, this work describes the research work that has been carried out regarding the description, fundamentally, of the persecution and deprivation of liberty of public opponents during this period, mainly, through the information found in the Museum of Justice. The decision to carry out this challenge has strengthened not only the participation of students as researchers but also the importance of memory, truth and justice as fundamental elements of Democracy in terms of academic awareness.Este artículo abarca dos aristas que se dividen en la formación del Semillero de Derechos Humanos de la Facultad de Derecho de la Universidad Americana (Semillero), así como en la decisión y ejecución de empezar un proyecto de investigación luego de la visita con estudiantes a dos museos: Museo de las Memorias y Museo de la Justicia, ambos relacionados con las violaciones de derechos humanos durante la dictadura de Alfredo Stroessner.  En este contexto, este trabajo describe el trabajo de investigación que se viene realizando en cuanto a la descripción, fundamentalmente, de la persecución y privación de libertad de opositores públicos durante este periodo, principalmente, a través de la información que se encuentra en el Museo de la Justicia. La decisión de llevar adelante este desafío viene fortaleciendo no solo la participación de los estudiantes como investigadores sino la importancia en cuanto a la conciencia académica de la memoria, la verdad y la justicia como elementos fundamentales de la Democracia.

Las competencias interuniversitarias Moot Court: una creativa estrategia de aprendizaje en materia de derecho

This article deals with the new way of learning offered by the interuniversity competencies called Moot Court and which were developed during 2019 and had as main activities and challenges; an intense training process, the study of a hypothetical case, the preparation of a written memorial and finally; the presentation of oral allegations before specialists in the matter that formed a Court. They were developed during 2019 and had as main activities and challenges; an intense training process, the study of hypothetical cases, the preparations of written memorials and finally; the presentation of oral allegations before specialists. The first one was framed in the field of Economic Criminal Law and Anti-Corruption, and the second one; in International Human Rights Law with emphasis on the Inter-American System for the Protection of Human Rights of the Organization of American States (OAS). Both cases were developed from a human rights approach with emphasis on Conventionality Control, fundamentally, because it is essential that the academy study it and insist that justice operators begin and consolidate the mainstreaming of international human rights standards as soon as to the precedents of the Inter-American Court of Human Rights (I / A Court HR).El presente artículo aborda la novedosa forma de aprendizaje que ofrecen las competencias interuniversitarias denominadas Moot Court desde la participación de la Facultad de Derecho de la Universidad Americana en dos de ellas durante el 2019. La primera de ellas estuvo enmarcada en el campo del Derecho Penal Económico y la segunda; en el Derecho Internacional de los Derechos Humanos con énfasis en el Sistema Interamericano de Protección de Derechos Humanos de la Organización de los Estados Americanos (OEA). Ambos casos se desarrollaron desde un enfoque de derechos humanos con énfasis en el Control de Convencionalidad, fundamentalmente; considerando la importancia de que la academia no solo lo estudie, sino que influya en los operadores de justicia para que estos consoliden la transversalización de los estándares internacionales de derechos humanos en cuanto a los precedentes de la Corte Interamericana de Derechos Humanos (Corte IDH) en su quehacer diario

Mutant p53 as a guardian of the cancer cell

Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a complex framework of diverse effector pathways and processes that protect cellular homeostasis and genome stability. Missense mutations in the TP53 gene are extremely widespread in human cancers and give rise to mutant p53 proteins that lose tumor suppressive activities, and some of which exert trans-dominant repression over the wild-type counterpart. Cancer cells acquire selective advantages by retaining mutant forms of the protein, which radically subvert the nature of the p53 pathway by promoting invasion, metastasis and chemoresistance. In this review, we consider available evidence suggesting that mutant p53 proteins can favor cancer cell survival and tumor progression by acting as homeostatic factors that sense and protect cancer cells from transformation-related stress stimuli, including DNA lesions, oxidative and proteotoxic stress, metabolic inbalance, interaction with the tumor microenvironment, and the immune system. These activities of mutant p53 may explain cancer cell addiction to this particular oncogene, and their study may disclose tumor vulnerabilities and synthetic lethalities that could be exploited for hitting tumors bearing missense TP53 mutations

Formación del Semillero de Derechos Humanos e investigación sobre memoria, verdad y justicia

This article covers two aspects that are divided into the formation of the Human Rights Seedbed of the Faculty of Law of the American University (Semillero), as well as in the decision and execution of starting a research project after the visits of two museums: Museum of Memories and Museum of Justice, both related to human rights violations during the dictatorship of Alfredo Stroessner. In this context, this work describes the research work that has been carried out regarding the description, fundamentally, of the persecution and deprivation of liberty of public opponents during this period, mainly, through the information found in the Museum of Justice. The decision to carry out this challenge has strengthened not only the participation of students as researchers but also the importance of memory, truth and justice as fundamental elements of Democracy in terms of academic awareness.Este artículo abarca dos aristas que se dividen en la formación del Semillero de Derechos Humanos de la Facultad de Derecho de la Universidad Americana (Semillero), así como en la decisión y ejecución de empezar un proyecto de investigación luego de la visita con estudiantes a dos museos: Museo de las Memorias y Museo de la Justicia, ambos relacionados con las violaciones de derechos humanos durante la dictadura de Alfredo Stroessner.  En este contexto, este trabajo describe el trabajo de investigación que se viene realizando en cuanto a la descripción, fundamentalmente, de la persecución y privación de libertad de opositores públicos durante este periodo, principalmente, a través de la información que se encuentra en el Museo de la Justicia. La decisión de llevar adelante este desafío viene fortaleciendo no solo la participación de los estudiantes como investigadores sino la importancia en cuanto a la conciencia académica de la memoria, la verdad y la justicia como elementos fundamentales de la Democracia.

Las competencias interuniversitarias Moot Court: una creativa estrategia de aprendizaje en materia de derecho

This article deals with the new way of learning offered by the interuniversity competencies called Moot Court and which were developed during 2019 and had as main activities and challenges; an intense training process, the study of a hypothetical case, the preparation of a written memorial and finally; the presentation of oral allegations before specialists in the matter that formed a Court. They were developed during 2019 and had as main activities and challenges; an intense training process, the study of hypothetical cases, the preparations of written memorials and finally; the presentation of oral allegations before specialists. The first one was framed in the field of Economic Criminal Law and Anti-Corruption, and the second one; in International Human Rights Law with emphasis on the Inter-American System for the Protection of Human Rights of the Organization of American States (OAS). Both cases were developed from a human rights approach with emphasis on Conventionality Control, fundamentally, because it is essential that the academy study it and insist that justice operators begin and consolidate the mainstreaming of international human rights standards as soon as to the precedents of the Inter-American Court of Human Rights (I / A Court HR).El presente artículo aborda la novedosa forma de aprendizaje que ofrecen las competencias interuniversitarias denominadas Moot Court desde la participación de la Facultad de Derecho de la Universidad Americana en dos de ellas durante el 2019. La primera de ellas estuvo enmarcada en el campo del Derecho Penal Económico y la segunda; en el Derecho Internacional de los Derechos Humanos con énfasis en el Sistema Interamericano de Protección de Derechos Humanos de la Organización de los Estados Americanos (OEA). Ambos casos se desarrollaron desde un enfoque de derechos humanos con énfasis en el Control de Convencionalidad, fundamentalmente; considerando la importancia de que la academia no solo lo estudie, sino que influya en los operadores de justicia para que estos consoliden la transversalización de los estándares internacionales de derechos humanos en cuanto a los precedentes de la Corte Interamericana de Derechos Humanos (Corte IDH) en su quehacer diario