Additional file 1: of Gender-specific associations between ADIPOQ gene polymorphisms and adiponectin levels and obesity in the Jackson Heart Study cohort

Table S1. Characteristics of the selected single nucleotide polymorphisms (SNPs) in the ADIPOQ gene. Table S2. Association between ADIPOQ SNPs and adiponectin serum levels in men and women from the Jackson Heart Study cohort. Table S3. Association between ADIPOQ SNPs and BMI in normal weight and overweight or obese men and women from the Jackson Heart Study cohort. (DOCX 28 kb

Additional file 1: of Circadian CLOCK gene polymorphisms in relation to sleep patterns and obesity in African Americans: findings from the Jackson heart study

Characteristics of the selected single nucleotide polymorphisms (SNPs) in the CLOCK gene (DOCX 17 kb

Characteristics and single-SNP association results for AIR_g SNPs in IRASFS.

<p>Characteristics and single-SNP association results for AIR_g SNPs in IRASFS.</p

Top meta-analyzed interactions with AIR_g SNPs regressed on T2D risk in ARIC, CARDIA, JHS, MESA, and WFSM.

<p>Top meta-analyzed interactions with AIR_g SNPs regressed on T2D risk in ARIC, CARDIA, JHS, MESA, and WFSM.</p

Additional file 2: Table S3. of Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes

Replication of AA-DHS admixture mapping results in JHS. (XLSX 11 kb

Additional file 1: Table S4. of Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes

Meta-analysis of 130 HU CAC scores in AA-DHS and JHS. (XLSX 230 kb

Additional file 3: Table S1. of Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes

List of SNPs with meta-analysis p-value less than 10–4. (XLSX 190 kb

Functional assays for α-globin enhancer variants.

<p>Normalized activity (RNA barcode count divided by DNA barcode count) from the massively parallel reporter assay. The median of the entire library was set to 0; therefore an activity of 0 corresponds roughly to minP transcriptional levels. Only elements overlapping with the MCS-R2 element have robust regulatory activity in K562 cells. (<b>B</b>) Relative luciferase activity as compared to minP promoter for α-globin enhancer variants (rs11865131 and rs11248850). A significant allelic difference in enhancer activity is observed for rs11865131 (p = 6.91 x 10⁻³ for lower luciferase activity with A allele). (<b>C</b>) Allelic skew for rs11865131 from DNase I hypersensitivity (DHS) data in 46 heterozygous cell types previously identified in(37) and in erythroblasts only ***p<0.0001.</p

Association of red cell and other clinically relevant phenotypes with sickle cell trait, stratified by number of copies of alpha-globin -3.7 kb deletion.

<p>Association of red cell and other clinically relevant phenotypes with sickle cell trait, stratified by number of copies of alpha-globin -3.7 kb deletion.</p

Association of red cell phenotypes with alpha-globin regulatory variant rs11248850, overall and by −α3.7 deletion status.

<p>Association of red cell phenotypes with alpha-globin regulatory variant rs11248850, overall and by −α3.7 deletion status.</p