24 research outputs found

    Serum Oxidative Stress Levels in Patients with Nasal Septal Deviation

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    Objective:Comparison of the total oxidant status (TOS), total antioxidant status (TAS) and paraoxonase (PON1) serum levels in patients with nasal septum deviation (NSD) and healthy subjects.Methods:The TAS, TOS, and PON1 serum levels of 47 patients with NSD (mean age 35.3) and 50 healthy subjects (mean age 37.8) were compared in this study.Results:We found significantly higher TAS levels in the control group (p<0.001). The mean TAS value was 1.196 mmoL/L in the control group, whereas it was 1.046 mmoL/L in the NSD group. On the other hand, TOS was significantly higher in the NSD group (p<0.001). We found that the mean TOS value was 6.600 mmoL/L in the control group, and 20.194 mmoL/L in the NSD group. The NSD and control groups had similar PON1 levels (p=0.446). The mean PON1 value was 279.64 U/L in the control group, and 324.21 U/L in the NSD group.Conclusion:We detected higher TOS and lower TAS levels in patients with NSD compared to healthy subjects. These results indicate that patients with NSD are exposed to oxidative stress

    Türk yargısının teknolojiyle imtihanı : 13 Mart 2005

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    Investigation of serum oxidative stress levels in patients with nasal polyps

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    Objective: To compare serum total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase (PON1) levels between nasal polyp patients and heal thy subjects. Method: In the present study, The nasal polyp group includes 26 males an 22 females, a total of 48 patients (mean age 37.11±12.07 years), while the control group included 22 males and 24 females, a total of 46 healthy subjects (mean age 36.91±13.03) years. Groups were compared in terms of serum TAS, TOS and PON1 levels. Results: The mean TAS level was 1.248 mmol/L in the control group, it was 1.176 mmol/L in the patient group (p=0.044). The mean TOS level was 3.443 mmol/L in the control group, and it was 6.720 mmol/L in the patient group (p=006). Nasal polyp and control groups did not show any significant difference for PON1 (301.15 U/L vs. 295.75 U/L,p>0.05). Conclusion: Serum TOS levels were significantly higher, and TAS levels were significantly lower in patients with nasal polyposis compared it the control group. There was no significant difference between the patients with nasal polypand the control group in terms of the PON1 values

    Is Routine Histopathologic Examination of Adenotonsillectomy Specimens Necessary?

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    Adenotonsillektomi endikasyonları, kronik enfeksiyonlar, peritonsiller abse, obstruksiyona yol açan adenoid veya tonsil hipertrofisi, yutma veya konuşma güçlüğüne ve çene ve diş anormalliklerine yol açacak derecede bu dokuların hipertrof'ıleri ve benign veya malign tümör şüphesini içermektedir. Çocuklarda en sık görülen tonsil tümörü lenfoma iken, yetişkinlerde en sık görülen tonsil tümörü skuamöz hücreli karsinomadır. Adenoid ve tonsil maligniteleri veya granülamatöz hastalıkları nadir görülmesine rağmen bu hastalıkları gözden kaçırma endişesi ve medikolegal sebepler nedeniyle birçok klinikte cerrahi olarak çıkartılan tüm dokuların histopatolojik incelenmesi yapılmaktadır. Adenoid ve tonsillerin histopatolojik incelenmeleri genellikle klinik sonucu değiştirmemektedir. Ayrıca gelişmekte olan ülkelerin ekonomisi için maddi bir yük ve patologlar için zaman alan bir işlemdir. Bununla ilgili birçok çalışma yapılmıştır. Bu çalışmaların bir kısmı sadece çocuk veya yetişkinlerde yapılırken, bir kısmı da hem çocuk hem de yetişkinleri kapsamaktadır. Çocuklarda adenoid ve tonsil dokularının histopatolojik inceleme sonuçlarında malinite görülme oranı %0-0.18 arasında bulunurken, yetişkinlerde malignite görülme oranı %0-2.04 arasında saptanmıştır. Sonuç olarak, adenoid ve tonsillerin rutin histopatolojik incelenmesine gerek olmayıp, tek veya çift taraflı tonsilin progresif büyümesi, servikal lenfadenopati, tonsilde kitle veya palpasyonda sertlik, malinite hikâyesi ve maliniteyi düşündüren sistemik semptomlar varsa adenoid ve tonsil dokularının histopatolojik tetkiki yapılmalıdır.Tonsillectomy with or without adenoidectomy is one of the most common surgical procedures performed in pediatric population. The indications for adenotonsillectomy include such as recurrent infection, peritonsillar abscesses, adenoid or tonsillar hypertrophy with obstruction, swallowing or speech abnormalities, severe orofacial or dental abnormalities, and suspected benign or malignant neoplasms. Lymphoma is the most seen tonsillar neoplasm in childhood, whereas squamous cell carcinoma is the most seen tonsillar neoplasm in adults. Although adenoid and tonsillar malignancy or granulomatosis diseases are seen rarely, histopatological evaluation of the all tissues extracted by surgery, are performed because of the fact that concern about overlook these disease and medicolegal reasons. Histopatological evaluation of adenoid and tonsils do not change the clinical outcomes. Furthermore it is financial burden for the developing countries and the evaluation process is time-consuming for the pathologist. Many studies were performed about this subject. Some of these studies adenoid and tonsils, however if some situations including progressive hypertrophy of unilateral or bilateral tonsils, cervical lymphadenopathy, lesion in the tonsils or firmness with palpation, history of malignancy and systemic symptoms concerning malignancy, are existing, the histopatological evaluation should be performed

    Tularemia as a cause of cervical lymphadenitis

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    The etiology of cervical lymphadenitis may be related to the many different reasons. It is stated that tularemia is a rare cause of cervical lymphadenitis. However, tularemia is seen as endemic in several regions in our country. Tularemia outbreaks have been reported recently. Tokat and surrounding area are the places where tularemia is seen as endemic. In this paper, seven patients with cervical lymphadenitis due to tularemia between 2007 and 2008 are presented. The aim of this paper is to emphasize that tularemia is an increasing cause of cervical lymphadenitis in our region although it is not described as a common reason for cervical lymphadenitis

    Life cycle assessment of soil stabilization using cement and waste additives

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    Environmental measures show that the effect of global temperature rise goes beyond the natural cycle of the Earth\u27s environmental system, which affects the social, economical, and health conditions of humanity. In this respect, initially, the UN\u27s sustainable development goals were adopted where, more recently, a UN net-zero coalition was formed to cut greenhouse gas emissions to as close to zero as possible by 2050 to resist foreseen catastrophic outcomes. As a result of these overwhelming goals and regulations, many nations are setting policies to achieve those targets. Nevertheless, such targets, to the best of our knowledge, have not penetrated well into construction applications. In this study, in addition to the mechanical responses of three different waste additives (bottom ash, marble dust and tire rubber powder to replace cement to stabilize problematic soils, a life-cycle assessment was performed to evaluate environmental impacts. Furthermore, a novel impact-performance approach has been introduced to satisfy safety, performance, and sustainability criteria. In this respect, unconfined compressive strength (UCS), initial stiffness (G0), accumulated loss of mass (ALM) due to wet-dry cycles, and life-cycle analysis (LCA) were performed on artificially cemented (7%, 10%, and 13%) clay specimens, compacted at 1600 and 1800 kg/m3 and cured for 28 days. Further, bottom ash (BA) (10% and 20%), marble dust (MD) (20% and 40%), and tire rubber powder (TRP) (2.5%, 5%, 10%, and 20%) were used to replace the cement, which is known for its great environmental impact. It is reported in this study that 2.5% TRP replacement of cement at low density seems to be the optimum dosage and additive, among others, to provide the best performance (UCS, G0, and ALM). Furthermore, the increase in cement content and density results in a positive contribution to performance indicators and a negative contribution to environmental impact. However, when impact-performance is considered, the opposite was observed, i.e., the rise in cement content, additive content, and density results in favourable contributions

    Patient and Doctor Delays in Smear-Negative and Smear-Positive Pulmonary Tuberculosis Patients Attending a Referral Hospital in Istanbul, Turkey

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    Objectives. To measure delays from onset of symptoms to initiation of treatment in patients with smear-negative and smear-positive pulmonary tuberculosis and to identify reasons for these delays. Methods. A total of 136 newly diagnosed pulmonary tuberculosis patients were interviewed using a structured questionnaire. Results. The patients were divided into two groups. Group 1 included 65 smear-negative patients. There were 71 smear-positive patients in group 2. The median application interval was 10 days in group 1 and 14 days in group 2. While 24.6% of the patients had patient delay in group 1, patient delay was present in 33.8% of the patients in group 2 (P>0.05). The median health care system interval was 41 days in group 1 and 16 days in group 2 (P<0.0001). The most common reason for patient delay was neglect of symptoms by patient in both groups. A low index of suspicion for tuberculosis by physicians was the most common reason for doctor delays. Conclusions. Delays are common problem in smear-negative and smear-positive pulmonary tuberculosis patients. Delays should be reduced to reach an effective tuberculosis control. Education of public and physicians about tuberculosis is the most important effort to reduce delays

    Pulmonary Sclerosing Hemangioma (Pneumocytoma): An Analysis of 8 Cases

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    Objective: We aimed to evaluate clinical manifestations, radiological findings, treatment, and outcomes of pulmonary sclerosing hemangioma (SH). Methods: We retrospectively reviewed eight cases of pulmonary sclerosing hemangioma diagnosed at our institution from January 2006 to April 2014. Their demografic findings, symptoms, radiological appearences, diagnostic methods, treatments and surveys were recorded. Results: There were four female and four male patients. The age at the time of diagnosis ranged from 23 to 79 years, with a mean age of 56.1 years. Two patients were asymptomatic. Among six symptomatic patients, hemoptysis was the most frequent symptom. The radiological feature was a solitary nodule or mass in seven cases. In the remaining case, there were multiple distinct masses and nodules in bilateral lung fields. The tumor involved lung parenchyma in seven cases and endobronchially located in the remaining patient. Seven patients with parenchymal location underwent surgery. Wedge resection was the most common surgical procedure. Diagnosis of SH was established by surgical biopsy in seven cases and by bronchoscopic biopsy in one case. The most common histological pattern was solid pattern. During the follow-up ranging from 2 months to 76 months, seven cases who underwent surgery had an excellent prognosis with no evidence of recurrence. The patient with multiple lesions died one month after diagnosis. Conclusion: SH of the lung is a rare tumor. Surgical resection usually requires for both diagnosis and treatment of this tumor. The patients had excellent prognosis with no evidence of recurrence following surgery

    Pulmonary Hamartomas: A Report of 13 Parenchymal and Endobronchial Cases

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    Objective: To analyze clinical, radiographic, bronchoscopic, and therapeutic characteristics of a series of patients in whom pulmonary hamartoma had been diagnosed. Methods: Retrospective review of cases of pulmonary hamartomas diagnosed by biopsy between January 2007 and May 2012 in a tertiary referral hospital in İstanbul, Turkey. Results: Of the 13 patients with histologically confirmed pulmonary hamartoma, seven were men and six were women (male/female 1.2/1). Their age ranged from 45 to 68 years old. Three patients were asymptomatic. The duration of symptoms ranged from one week to two years. Chest radiograph findings were abnormal in all patients. The lesions were located in the right lung in nine cases, with lower lobe predilection. Among the patients with pulmonary hamartoma, four (30.8%) had endobronchial hamartoma. Treatment modality was wedge resection in five cases, enucleation in four cases, bronchoscopic procedures in three cases and lobectomy in one case. Follow-up ranged from one month to 54 months. No tumor recurrence was encountered in the follow-up period. Conclusion: Pulmonary hamartomas are uncommon benign lesions of the lung. They can be parenchymal or endobronchial in location. Parenchyma sparing surgical procedures such as wedge resection or enucleation and bronchoscopic intervention should be preferred in the treatment of pulmonary hamartomas
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