Repurposing the oncolytic virus VSV∆51M as a COVID-19 vaccine

The coronavirus disease 2019 (COVID-19) pandemic imposes an urgent and continued need for the development of safe and cost-effective vaccines to induce preventive responses for limiting major outbreaks around the world. To combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we repurposed the VSV∆51M oncolytic virus platform to express the spike receptor-binding domain (RBD) antigen. In this study, we report the development and characterization of the VSV∆51M-RBD vaccine. Our findings demonstrate successful expression of the RBD gene by the VSV∆51M-RBD virus, inducing anti-RBD responses without attenuating the virus. Moreover, the VSV∆51M-RBD vaccine exhibited safety, immunogenicity, and the potential to serve as a safe and effective alternative or complementary platform to current COVID-19 vaccines

Contractor Selection Criteria (Gift of The Givers Child Care Center project Case Study)

Over 20 years ago, the common and only factor for evaluating bids and selecting contractors is "the bid price". Recent studies showed that there are many other important factors have to be taken into account when evaluating bids and selecting contractors, in order to implement a project with an acceptance level of quality that satisfy clients.These factors can be found in the literature of this paper. This paper presents a literature in the field of contractor selection stages and the most important factors when evaluating bids, and compares these stages and factorsof a practical example in Gaza strip. This study found thatthe stages of contractors selection in the literature and in the case study are the same, but there are some differences between the factors were taken into account in each stage, the lowest cost factor still the most importantfactor in this project. Findings of the study are recommendations for the clients in the field of bids evaluation and contractor selection in order to ensure efficiency, transparency and fairness in selecting contractors