The Effect of Excess Reserves on U.S Real Gross Domestic Product

The recent financial crisis has triggered questions regarding the role of the Federal Reserve Bank and the effectiveness of its intervention in the financial markets, post the crisis. This paper investigates the impact of huge spikes in excess reserves on the U.S. real gross domestic product. U.S. Federal Reserve in an effort to deal with the 2008 financial crisis instituted a series of programs aimed at taming the impact of the crisis. Through its emergency lending activities and Quantitative Easing (QE) programs, the Federal Reserve created a huge spike in excess reserves to levels not seen before. The empirical findings of this research show that a negative correlation exist between excess reserve and U.S. real gross domestic product. In fact the results show that a 5% increase in excess reserves results in a 0.1% reduction in real GDP activity. The analysis also indicates that an increase in excess reserves negatively impact full employment and asset prices. Additionally, Federal funds rate show a significantly positive association to real gross domestic product, possibly evidencing the Feds payment of interest on excess reserves

Characteristics of ADHD symptom response/remission in a clinical trial of methylphenidate extended release

Clinical trials in attention-deficit/hyperactivity disorder (ADHD) have typically measured outcome using clinician ratings on the Attention-Deficit/Hyperactivity Disorder Rating Scale, Fourth Edition (ADHD-RS-IV) and the Clinical Global Impression-Improvement (CGI-I) scale. Remission has been defined as an endpoint score of less than or equal to 18 on the ADHD-RS-IV (or a mean score of 1). Responders have been defined as patients who achieve a CGI-I score of much or very much improved (1 or 2). There is a lack of agreement in the literature on what percent change in symptoms on the ADHD-RS-IV should be used to define improvement or remission. This study uses data from a clinical trial of a methylphenidate extended release (MPH-MLR; Aptensio XR®) phase III clinical trial to attempt to determine the percent change of symptoms that best corresponds with improvement and remission. Symptom remission at endpoint (ADHD-RS-IV total score ≤18) was most closely aligned with a ≥46% reduction in ADHD-RS-IV total score. Clinical improvement was most closely aligned with a ≥40% reduction in ADHD-RS-IV total score. The three different measures of outcome were strongly aligned during double blind and open label treatment, and were independent of subtype status. Our data suggest that at least 40% improvement in symptoms is needed to achieve a robust response at endpoint

The female heart: sex differences in the dynamics of ECG in response to stress

Sex differences in the study of the human physiological response to mental stress are often erroneously ignored. To this end, we set out to show that our understanding of the stress response is fundamentally altered once sex differences are taken into account. This is achieved by comparing the heart rate variability (HRV) signals acquired during mental maths tests from ten females and ten males of similar maths ability; all females were in the follicular phase of their menstrual cycle. For rigor, the HRV signals from this pilot study were analyzed using temporal, spectral and nonlinear signal processing techniques, which all revealed significant statistical differences between the sexes, with the stress-induced increases in the heart rates from the males being significantly larger than those from the females (p-value = 4.4 × 10−4). In addition, mental stress produced an overall increase in the power of the low frequency component of HRV in the males, but caused an overall decrease in the females. The stress-induced changes in the power of the high frequency component were even more profound; it greatly decreased in the males, but increased in the females. We also show that mental stress was followed by the expected decrease in sample entropy, a nonlinear measure of signal regularity, computed from the males' HRV signals, while overall, stress manifested in an increase in the sample entropy computed from the females' HRV signals. This finding is significant, since mental stress is commonly understood to be manifested in the decreased entropy of HRV signals. The significant difference (p-value = 2.1 × 10−9) between the changes in the entropies from the males and females highlights the pitfalls in ignoring sex in the formation of a physiological hypothesis. Furthermore, it has been argued that estrogen attenuates the effect of catecholamine stress hormones; the findings from this investigation suggest for the first time that the conventionally cited cardiac changes, attributed to the fight-or-flight stress response, are not universally applicable to females. Instead, this pilot study provides an alternative interpretation of cardiac responses to stress in females, which indicates a closer alignment to the evolutionary tend-and-befriend response

Sewage Sludge as an Alternative Fertilizer for Tropical Pasture Grasses

This study was conducted to determine the effects of source (Liquid sludge at pH 7 (LS7) or pH 11 (LS11), cake biosolid (CB) or ammonium nitrate (AM)) by rate (0, 80 or 160 kg ha-1) of N application on bahiagrass forage yield, quality and tissue composition. Same plots were fertilized in March 1998 and 1999. Forage yield was measured at 30 d intervals from May through November and subsamples were dried and ground for quality analyses. The 2-year mean forage yield was similar for AM, LS7 and LS 11 fertilizer applications. Forage yield from CB application was 30% lower than yield from other N sources at comparable N rates. Forage crude protein content was highest for the AM treatment only during the initial harvest. Tissue concentrations of plant nutrients were increased by organic sources of fertilizer. These results, in conjunction with data from soil and groundwater analyses, suggest that processed domestic septage could be a safe and inexpensive substitute to inorganic fertilizer for tropical pasture grasses

Farmers' agronomic and social evaluation of productivity yield and N2-fixation in different cowpea varieties and their subsequent residual N effects on a succeeding maize crop

Cowpea-maize rotations form an important component of the farming systems of smallholder farmers in the forest/savannah transitional agro-ecological zone of Ghana. We evaluated five cowpea varieties for grain yield, N-2-fixation, biomass production, and contribution to productivity of subsequent maize grown in rotation. We further analyzed the interrelationship between these technical dimensions and the social acceptability of these cowpea varieties for farmers. Cowpea grain yield ranged between 1.1 and 1.4 t ha(-1) with no significant yield differences among the different varieties. Using the N-15 natural abundance technique, the average proportion of N-2 fixed ranged between 61% for Ayiyi and 77% for Legon prolific. This resulted in average amounts of N-2 fixed in above-ground biomass ranging between 32 and 67 kg N ha(-1), respectively. Variation in estimates due to differences in delta N-15 among reference plants were larger than differences between cowpea varieties. The amount of soil-derived N ranged from 15 to 20 kg N ha(-1). The above-ground net N contribution of the cowpea varieties to the soil (after adjusting for N export in grains) was highest for Legon Prolific (31 kg N ha(-1)) due to high N-2-fixation and high leaf biomass production. Maize grain yield after cowpea without application of mineral N fertilizer ranged between 0.4 t ha(-1) with maize after maize to 1.5 t ha(-1) with Legon Prolific. The N fertilizer equivalence values for the cowpea varieties ranged between 18 and 60 kg N ha(-1). IT810D-1010 was ranked by the farmers as the most preferred cowpea variety due to its white seed type, short-duration, ease of harvesting and good market value. Despite the high leaf biomass production and high amount of N-2 fixed by Legon Prolific, it was generally the least preferred variety due to lower market price, late maturity, least potential cash income (due to the red mottled seed type) and difficulty in harvesting. Although farmers recognized the contribution of cowpea to soil fertility and yields of subsequent maize, they did not consider this as an important criterion for varietal selection. Soil fertility improvement must be considered as an additional benefit rather than a direct selection criterion when designing more sustainable smallholder farming systems

Contraception needs and pregnancy termination in sub-Saharan Africa: a multilevel analysis of demographic and health survey data

Background: Women in sub-Saharan Africa (SSA) have a higher risk of unintended pregnancies that are more likely to be terminated, most of which are unsafe with associated complications. Unmet need for contraception is highest in SSA and exceeds the global average. This study investigates the association between unmet/met need for contraception and pregnancy termination SSA. Methods: We used pooled data from Demographic and Health Surveys conducted from January 2010 to December 2018 in 32 countries in SSA. Our study involved 265,505 women with diverse contraception needs and with complete data on all variables of interest. Multilevel logistic regression at 95% CI was used to investigate the association between individual and community level factors and pregnancy termination. Results: We found an overall pregnancy termination rate of 16.27% ranging from 9.13% in Namibia to 38.68% in Gabon. Intriguingly, women with a met need for contraception were more likely to terminate a pregnancy [aOR = 1.11; 95% CI 1.07–1.96] than women with unmet needs. Women with secondary education were more likely to terminate a pregnancy as compared to those without education [aOR = 1.23; 95% CI 1.19–1.27]. With regards to age, we observed that every additional age increases the likelihood of terminating a pregnancy. At the contextual level, the women with female household heads were less likely to terminate a pregnancy [aOR = 0.95; 95% CI 0.92–0.97]. The least socio-economically disadvantaged women were less likely to terminate a pregnancy compared to the moderately and most socio-economically disadvantaged women. Conclusions: Our study contributes towards the discussion on unmet/met need for contraception and pregnancy termination across SSA. Women with met need for contraception have higher odds of terminating a pregnancy. The underlying cause of this we argued could be poor adherence to the protocols of contraceptives or the reluctance of women to utilise contraceptives after experiencing a failure. Governments of SSA and non-governmental organisations need to take pragmatic steps to increase met needs for contraception and also utilise mass media to encourage women to adhere to the prescription of contraceptives in order to reduce the incidence of unplanned pregnancies and unsafe abortions

Household access to groundwater and its implication in an urban poor community, Ghana

The access to drinking water in urban informal settlements of developing countries is a challenge for the poor. The objective of the study was to determine access to groundwater supply and its implication to consumers. A survey of 300 households in the study site showed that the households’ main water sources were public standpipe (37%), pipe water into buildings (20.67%), unprotected dug well (15%) and protected well (13%), motorized borehole (5.67%) and hand-pump borehole (4%). The groundwater use was high with about 78% of households accessing it as a main source or secondary source. Results showed that 96% of all the households use sachet water as a major source of drinking water. The households view the groundwater as unwholesome for drinking because of its salty taste, impurities and colour

Physicians' knowledge, attitudes, and perceptions concerning antibiotic resistance:a survey in a Ghanaian tertiary care hospital

Abstract Background Understanding the knowledge, attitudes and practices of physicians towards antibiotic resistance is key to developing interventions aimed at behavior change. The survey aimed to investigate physicians’ knowledge and attitudes towards antibiotic resistance in a tertiary-care hospital setting in Ghana. Methods We conducted a cross-sectional respondent-driven survey using a 40-item, anonymous, voluntary, traditional paper-and-pencil self-administered questionnaire among 159 physicians at Korle-Bu Teaching Hospital. Single and multi-factor analysis were conducted to assess the study objectives. Results The survey was completed by 159 of 200 physicians (response rate of 79.5%). Of physicians, 30.1% (47/156) perceived antibiotic resistance as very important global problem, 18.5% (29/157) perceived it as very important national problem and only 8.9% (14/157) thought it as a very important problem in their hospital. Methicillin resistant Staphylococcus aureus was the most known about antibiotic resistant bacteria of public health importance followed by extended-spectrum beta-lactamase-producing Enterobacteriaceae, carbapenem resistant Enterobacteriaceae (CRE) and vancomycin resistant enterococci (VRE). In multiple logistic regression analysis, senior physicians were nearly 3 times more likely to know about CRE than junior physicians. The odds of knowing about VRE increased over 4.5 times from being a junior to becoming senior physician. Among junior physicians, age had no associated effect on their knowledge of VRE or CRE. Conclusions Physicians in this survey showed variable knowledge and perceptions on antibiotic resistance. Introducing educational programs on antibiotic resistance would be a useful intervention and should focus on junior physicians