4 research outputs found
Ameliorative Activity of Ethanol Extract of Artocarpus heterophyllusStem Bark on Pancreaticb-Cell Dysfunction in Alloxan-Induced Diabetic Rats
This study sought to investigate the ameliorative effects of ethanol extractArtocarpus heterophyllus(EAH) in alloxan-induced diabetic
rats. The rats were divided into 6 groups, with groups 1 and 2 serving as nondiabetic and diabetic control, respectively; group 3 serving
as diabetic rats treated with 5 mg/kg glibenclamide; and groups 4 to 6 were diabetic rats treated with 50, 100, and 150 mg/kg of EAH,
respectively. Assays determined were serum insulin, lipid peroxidation, and antioxidant enzyme activities. EAH stem bark reduced
fasting blood glucose and lipid peroxidation levels and increased serum insulin levels and activities of antioxidant enzymes. Data
obtained demonstrated the ability of EAH stem bark to ameliorate pancreaticb-cell dysfunction in alloxan-induced diabetic rats
Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats
Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats. Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days. Results: At the end of the intervention, diabetic control rats showed significant (p0.05) different with non-diabetic rats. Conclusion: The results suggest that ethanol extract of Artocarpus heterophyllus stem bark may be useful in ameliorating complications associated with diabetes mellitus patients
Inhibitor y effect on key enzymes relevant to acute type-2 diabetes and antioxidative activity of ethanolic extract of Artocarpus heterophyllus stem bark
Objective: To investigate the in vitro antioxidant activity of ethanolic extract of Artocarpus heterophyllus (A. heterophyllus) stem bark and its inhibitory effect on a-amylase
and a-glucosidase.
Methods: The A. heterophyllus stem bark was extracted using methanol and tested for
antioxidative activity.
Results: The results revealed that the ethanolic extract has polyphenolics and free radical
scavenging compounds which were significantly higher (P < 0.05) than their respective
standard, at concentration dependent manner. The ethanolic extract of A. heterophyllus stem
bark was observed to show inhibitory activities on a-amylase and a-glucosidase with IC50 of
(4.18 ± 0.01) and (3.53 ± 0.03) mg/mL, respectively. The Lineweaver-Burk plot revealed
that ethanolic extract of A. heterophyllus stem bark exhibited non-competitive inhibition for
a-amylase and uncompetitive inhibition for a-glucosidase activities. Also, gas chromatography–mass spectrometry showed the presence of different bioactive compounds in extract.
Conclusions: Therefore, it can be inferred from this study that ethanolic extract of
A. heterophyllus stem bark may be useful in the management of diabetes mellitus
probably due to bioactive compounds observed in the extract