2 research outputs found
Reversible Renal Failure in Hypertensive Idiopathic Nephrotics Treated with Captopril
Angiotensin converting enzyme inhibitor (ACEI)- induced acute renal failure (ARF) is not as commonly reported in children as in adults. We report two cases of idiopathic nephrotic syndrome that developed ARF following captopril (an ACEI) treatment for prednisolone-induced hypertension. The two cases further alert us to the potential risk of ACEI-induced ARF in any nephrotic child on ACEI treatment. Low or high dose ACEIs should be given with extreme caution in active nephrotics in view of their relative hypovolemic state that may provoke ARF. The nephrotic children, who must be treated with ACEIs with or without diuretics, should be closely monitored for the development of ARF during the use of ACEIs
Microstructural Observations on Nissl Substances in the Cerebellar Cortex of Adult Wistar Rats following Quinine Administration
Purpose: This study assessed some microstructural effects of quinine,
commonly used in malaria chemotherapy, especially in
chloroquine-resistant and cerebral malaria, on the Nissl substance in
the cerebellar cortex of adult Wistar rats using microanatomical
studies. Methods: Twenty seven adult male Wistar rats, weighing
between 150g and 190g, were randomly separated into groups A, B and C
(n=9). The rats in group A served as the control and received
intramuscular injection of physiological saline. Group B rats were
injected intramuscularly with liquid quinine, 16mg/kg body weight as a
start dose, followed by 8mg/kg body weight 8 hourly for seven days.
Group C rats received the same treatment as group B but were subjected
to a withdrawal period of one week. Groups A and B rats were sacrificed
at the end of the treatment while group C rats were sacrificed at the
end of one week. The cerebellum of each rat was removed and fixed in
10% formol saline for histological analysis. Results: The findings
showed that the Nissl substances in the cerebellar cortex in control
rats stained more intensely and distinctly compared with the less
intense stain and degenerated Nissl substances in the treated rats.
Conclusion: The observed degenerative changes in the Nissl substances
in the cerebellar cortex of the treated rats may affect the synthesis
of proteins in correlation with neuronal functions