Use of Intravenous Lipid Emulsion in Dogs With Suspected Tremorgenic Mycotoxicosis:53 Cases

AbstractObjective: The purpose of this study is to report the use of intravenous lipid emulsion (ILE) in dogs presenting with suspected tremorgenic mycotoxicosis based on signs of intoxication and known ingestion of mouldy food or compost.Background: ILE is being used for toxicoses associated with fat soluble agents. As tremorgenic mycotoxins are lipophilic in nature, the use of ILE may be of benefit in these patients. Methods: Medical records of all dogs examined at any Vets Now clinic between November 2012 and November 2016, in which ILE had been used, were reviewed and 53 cases were included in the study.Results: In 96% of cases there was clinical improvement recorded post ILE administration within a median time of 4 hours. No adverse effects were seen during the infusion or up to the time of discharge.Conclusion: The administration of ILE seems to be associated with a beneficial effect in the short term in dogs. Prospective evaluation of this therapy is warranted to further evaluate the use of ILE in these cases. <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" /

Uterine rupture and septic peritonitis following dystocia and assisted delivery in a Great Dane bitch

A Great Dane bitch was treated for presumed primary uterine inertia with repeated doses of oxytocin and manually assisted whelping. She was diagnosed with uterine rupture and septic peritonitis the following day. The uterine rupture is hypothesized to have occurred as a result of the management strategy used to treat dystocia. The dog underwent ovariohysterectomy, and the septic peritonitis was managed with open peritoneal drainage. The dog recovered well and was discharged 5 days later. No previous reports of canine uterine rupture associated with manual intervention appear to have been published. This report highlights the potential dangers involved in such an approach.</jats:p

Circulating hyaluronan as a marker of endothelial glycocalyx damage in dogs with myxomatous mitral valve disease and dogs in a hypercoagulable state

The endothelial glycocalyx (eGlx) lines the luminal surface of endothelial cells, maintaining vascular health. Glycocalyx damage is pathophysiologically important in many diseases across species however few studies have investigated its breakdown in naturally occurring disease in dogs. The aims of the study were to investigate eGlx damage in dogs with myxomatous mitral valve disease (MMVD) diagnosed on echocardiography, and dogs in a hypercoagulable state diagnosed using thromboelastography (TEG), by measuring serum hyaluronan concentrations. Serum hyaluronan was quantified in dogs with MMVD (n = 27), hypercoagulability (n = 21), and in healthy controls dogs (n = 18). Serum hyaluronan concentrations were measured using a commercially-available ELISA validated for use in dogs. Hyaluronan concentrations were compared among groups using Kruskal-Wallis tests, and post-hoc with Dunn’s tests. Serum hyaluronan concentrations (median [range]) were significantly increased in dogs with MMVD (62.4 [22.8–201] ng/mL; P = 0.031) and hypercoagulability (92.40 [16.9–247.6] ng/mL; P < 0.001) compared to controls (45.7 [8.7–80.2] ng/mL). Measurement of serum hyaluronan concentration offers a clinically applicable marker of eGlx health and suggests the presence of eGlx damage in dogs with MMVD and dogs in a hypercoagulable state