44 research outputs found
Influence of alleycropping microclimate on the performance of groundnut (Arachis hypogaea L.) and sesame (Sesamum indicum L.) in the semi-desert region of northern Sudan
An alley cropping system was established at Hudieba Research Station (17.57’N and 33.8’ E) on a loamy sand soil of the semi-desert region of northern Sudan. The objective of this study was to investigate the influence of modified microclimate in 6-m wide alleys formed by Acacia ampliceps and Acacia stenophylla on growth and yield of groundnut. and sesame. Above-ground interactions were determined by measuring air temperature, relative humidity, wind speed, solar energy and shade length and behaviour. Groundnut and sesame were evaluated for growth and yield by laying out sample plots at southern, central and northern part of the alleys and at control plots. Due to microclimatic modifications in the alleys, the yield of both crops in the alleys significantly (p=0.01) exceeded that of the sole crop. Yield reduction at the northern alley was fully compensated by high yield increase at southern and central alleys. The yield of groundnut increased by 37.7 and 19.6 % in the A.stenophylla and A.ampliceps alleys, respectively. On the other hand, the yield of sesame increased with the stenophylla-alley (+40.3%), while it decreased with ampliceps-alley (-51.5%). The results indicated that the competition for light was the major factor contributing to the increase or reduction of growth and yield of groundnut and sesame
The Role of Islamic Education Teacher in Moral Education: A Case Study of (IIS) Malaysia
The main purpose of this study is to investigate how the role of Islamic education teachers may influence in nurturing students’ morality. Teaching and nurturing students’ morality across curriculum is one of the important characteristics of the Integrated Curriculum for Secondary Schools in Malaysia. Its main drive is to enhance the potential of the individual students in a holistic, integrated and balanced manner that considers his spiritual, intellectual, emotional and physical growth. The researchers purposively selected two teaching staff from International Islamic School (IIS), Malaysia. The results of Semi-structured interviews revealed that teachers were satisfied about the process of teaching and nurturing students’ moral during the school hours. It was also found that negative influence of peers, some friends outside the school, parents at home had affected the students’ moral behaviour to some extent. The teachers felt that there is a need for support from the school administrator, parents, as well as media in order to reduce moral decay among students at school
The Role of Islamic Education Teacher in Moral Education: A Case Study of (IIS) Malaysia
The main purpose of this study is to investigate how the role of Islamic education teachers may influence in nurturing students’ morality. Teaching and nurturing students’ morality across curriculum is one of the important characteristics of the Integrated Curriculum for Secondary Schools in Malaysia. Its main drive is to enhance the potential of the individual students in a holistic, integrated and balanced manner that considers his spiritual, intellectual, emotional and physical growth. The researchers purposively selected two teaching staff from International Islamic School (IIS), Malaysia. The results of Semi-structured interviews revealed that teachers were satisfied about the process of teaching and nurturing students’ moral during the school hours. It was also found that negative influence of peers, some friends outside the school, parents at home had affected the students’ moral behaviour to some extent. The teachers felt that there is a need for support from the school administrator, parents, as well as media in order to reduce moral decay among students at school. Keywords: Moral education, Moral decay. Secondary level, Teacher perceptions
Blood group and Rhesus antigens among Blood donors attending the Central Blood Bank, Sudan
Background: It is well known that the Rhesus system remains the second most clinically important blood group system after the ABO. There is no published work regarding the frequency of various Rhesus antigens among Sudanese population.Objectives: In order to minimize Rhesus allo-immunization among blood recipients a cross sectional study was conducted to determine the frequency of various Rhesus antigens among the blood donors attending the Central Blood Bank in Khartoum.Methods: Two hundred male blood donors were enrolled in the study. ABO and Rhesus typing were performed using the classical slide method and gel micro typing system.Results: The frequency percentage of ABO blood phenotypes in the total samples were as follows: O(51.5%), A (29.5%), B (16%), and AB (6%); whereas the frequency percentage of Rh antigens were D (93%), e (79.5%), c (68.5%), C, (27%), E (18.5%).Conclusion: We concluded that the frequency of the Rh antigens can be shown in this order D > e > c > C > E. Special precautions need to be undertaken to minimize any possible allo-immunization by such antigens.Keywords: Frequency, Rhesus antigens, phenotyping, Blood group
Effects of skipping one irrigation at different growth stages on yield and water productivity of some maize (Zea mays L.) cultivars under heavy clay soils of central Sudan
Crop production in arid and semi-arid regions faces the challenge to ensure high yields with limited supply of water. This study was conducted at the experimental farm of the Faculty of Agricultural Sciences, University of Gezira, during seasons 2014/15 and 2015/16. The objectives of this study were to investigate the effects of skipping one irrigation on yield and yield components of maize (Zea mays L.). A split-plot design with four replicates was used. Main plots were assigned to the cultivars namely: Hudaiba1, Hudaiba2 and Mogtamaa -45, and sub-plots to irrigation treatments which consisted of (T1) irrigation every 10 days throughout the season (control), skipping one irrigation at: Vegetative (T2), flowering (T3) and grain filling (T4) stages. The results indicated that irrigation treatments and cultivars had highly significant effects on all parameters tested. Irrigation every 10 days resulted in the highest values of plant height, cob length, number of grains per cob, 100 seed weight, grain yield and water productivity. Hudaaiba2 outyielded the other two cultivars. Skipping one irrigation at flowering (T3) stage gave the lowest values of the tested parameters. The highest grain yield was obtained when frequent irrigation (control) and Hudaiba 2 was practiced and the lowest was obtained by skipping of irrigation at flowering, which reflected the sensitivity of this stage for water deficit. Hence, it is recommended to grow Hudaiba2 maize cultivar and irrigate every 10 days
Conflict and tuberculosis in Sudan: a 10-year review of the National Tuberculosis Programme, 2004-2014
Background
Sudan is a fragile developing country, with a low expenditure on health. It has been subjected to ongoing conflicts ever since 1956, with the Darfur crisis peaking in 2004. The conflict, in combination with the weak infrastructure, can lead to poor access to healthcare. Hence, this can cause an increased risk of infection, greater morbidity and mortality from tuberculosis (TB), especially amongst the poor, displaced and refugee populations. This study will be the first to describe TB case notifications, characteristics and outcomes over a ten-year period in Darfur in comparison with the non-conflict Eastern zones within Sudan.
Methods
A cross-sectional review of the National Tuberculosis Programme (NTP) data from 2004 to 2014 comparing the Darfur conflict zone with the non-conflict eastern zone.
Results
New case notifications were 52% lower in the conflict zone (21,131) compared to the non-conflict zone (43,826). Smear-positive pulmonary TB (PTB) in the conflict zone constituted 63% of all notified cases, compared to the non-conflict zone of 32% (p < 0.001). Extrapulmonary TB (EPTB) predominated the TB notified cases in the non-conflict zone, comprising 35% of the new cases versus 9% in the conflict zone (p < 0.001). The loss to follow up (LTFU) was high in both zones (7% conflict vs 10% non-conflict, p < 0.001) with a higher rate among re-treatment cases (12%) in the conflict zone. Average treatment success rates of smear-positive pulmonary TB (PTB), over ten years, were low (65-66%) in both zones. TB mortality among re-treatment cases was higher in the conflict zone (8%) compared to the non-conflict zone (6%) (p < 0.001).
Conclusion
A low TB case notification was found in the conflict zone from 2004 to 2014. High loss to follow up and falling treatment success rates were found in both conflict and non-conflict zones, which represents a significant public health risk. Further analysis of the TB response and surveillance system in both zones is needed to confirm the factors associated with the poor outcomes. Using context-sensitive measures and simplified pathways with an emphasis on displaced persons may increase access and case notification in conflict zones, which can help avoid a loss to follow up in both zones
Attenuating the DNA damage response to double strand breaks restores function in models of CNS neurodegeneration
DNA double-strand breaks are a feature of many acute and long-term neurological disorders, including neurodegeneration, following neurotrauma and after stroke. Persistent activation of the DNA damage response in response to double strand breaks contributes to neural dysfunction and pathology as it can force post-mitotic neurons to re-enter the cell cycle leading to senescence or apoptosis. Mature, non-dividing neurons may tolerate low levels of DNA damage, in which case muting the DNA damage response might be neuroprotective. Here, we show that attenuating the DNA damage response by targeting the meiotic recombination 11, Rad50, Nijmegen breakage syndrome 1 complex, which is involved in double strand break recognition, is neuroprotective in three neurodegeneration models in Drosophila and prevents Aβ1-42-induced loss of synapses in embryonic hippocampal neurons. Attenuating the DNA damage response after optic nerve injury is also neuroprotective to retinal ganglion cells and promotes dramatic regeneration of their neurites both in vitro and in vivo. Dorsal root ganglion neurons similarly regenerate when the DNA damage response is targeted in vitro and in vivo and this strategy also induces significant restoration of lost function after spinal cord injury. We conclude that muting the DNA damage response in the nervous system is neuroprotective in multiple neurological disorders. Our results point to new therapies to maintain or repair the nervous system
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
The khmer software package: enabling efficient nucleotide sequence analysis [version 1; referees: 2 approved, 1 approved with reservations]
The khmer package is a freely available software library for working efficiently with fixed length DNA words, or k-mers. khmer provides implementations of a probabilistic k-mer counting data structure, a compressible De Bruijn graph representation, De Bruijn graph partitioning, and digital normalization. khmer is implemented in C++ and Python, and is freely available under the BSD license at https://github.com/dib-lab/khmer/
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study
Background:
Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.
Methods:
Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.
Results:
A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.
Conclusions:
IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients