The natural history of acute Ebola Virus Disease among patients managed in five Ebola treatment units in West Africa: A retrospective cohort study - Fig 3

<p><b>A. Kaplan-Meier survival analysis by day of illness for EBOV positive patients disaggregated by sex. B. Kaplan-Meier survival analysis by day of illness for EBOV positive patients disaggregated by age</b>. *Variables have been abbreviated: Abdominal Pain = “Abd Pain”; Nausea/Vomiting = “Vomiting”; Myalgias/Arthralgias = “Myalgias”; Conjunctivitis = “Red Eyes”.</p

Baseline demographics and mortality risk by demographic subgroup for EBOV positive patients with known symptom onset date.

<p>Baseline demographics and mortality risk by demographic subgroup for EBOV positive patients with known symptom onset date.</p

Initial cycle threshold (CT) values and mean CT values over entire length of illness for all EBOV positive patients and for individual demographic subgroups.

<p>Initial cycle threshold (CT) values and mean CT values over entire length of illness for all EBOV positive patients and for individual demographic subgroups.</p

Kaplan-Meier survival analysis by symptom day for EBOV positive patients.

<p>Kaplan-Meier survival analysis by symptom day for EBOV positive patients.</p

Mean days of symptoms prior to ETU arrival for all patients and for individual subgroups.

<p>Mean days of symptoms prior to ETU arrival for all patients and for individual subgroups.</p

Test characteristics.

<p>*The cut point refers to the position on the receiver operating characteristic curve that corresponds to the best test characteristics for the Clinical Dehydration Scale (CDS), Gorelick scale, and physician gestalt respectively. The World Health Organization (WHO) scale test characteristics are based on a predefined cut point. Abbreviations: AUC, area under the receiver operating characteristic curve; SN, sensitivity; SP, specificity; LR+, likelihood ratio positive; LR-, likelihood ratio negative.</p

Receiver Operating Characteristic Curves.

<p>Abbreviations: CDS, Clinical Dehydration Scale; WHO, World Health Organization; G, Gorelick; MD, Physician.</p

Clinical dehydration scale (CDS).

<p>Scoring: 0: no dehydration < 3%, 1-4: some dehydration ≥ 3% - 6%, 5-8: moderate dehydration ≥ 6%.</p

Subgroup analysis by age of child from which each scale was derived.

<p>Abbreviations: CDS, Clinical Dehydration Scale; AUC, area under the receiver operating characteristic curve; CI, confidence interval.</p

Multivariate linear regression analysis, Kambia and Makeni, Sierra Leone, December 2014 to April 2015.

<p>Multivariate linear regression analysis, Kambia and Makeni, Sierra Leone, December 2014 to April 2015.</p