Academician Tudor Lupascu, Happy Anniversary!

The Moldovan scientific community has recently celebrated Academician Tudor Lupascu on the occasion of his 70’s anniversary

Synthesis and Evaluation of Antimicrobial Activity of Tetranorlabdane Compounds Bearing 1,3,4-Thiadiazole Units

Synthesis of novel tetranorlabdane compounds bearing 1,3,4-thiadiazole units and intermediary tetranorlabdane compounds with thiosemicarbazone fragment has been reported. The structures of the new synthesized compounds were confirmed using IR and 1H, 13C, and 15N NMR spectroscopy. The in vitro antifungal and antibacterial activities of the mentioned compounds have been evaluated. Results of this study have shown that the 1,3,4-thiadiazole-2-imine has excellent activity against tested strains of fungi and species of bacteria at minimum inhibitory concentration values of 0.125 and 2.5 μg/mL, respectively

Chemical Composition and Antimicrobial Activity of the Levisticum Officinale W.D.J. Koch Essential Oil

The chemical composition of industrially obtained Levisticum officinale W.D.J. Koch (lovage) essential oil of Moldovan origin was analysed by means of chromatographic (GC-MS) and spectral (IR, 1H and 13C NMR) methods. The obtained results show that the main components of L. officinale essential oil are monoterpenic hydrocarbons which make up to 53.50% of the total number of components. L. officinale essential oil is also characterized by a high content of oxygenated monoterpenes (alcohols, cetones and esters), which reaches up to 33.60%. For the first time the presence of 6-butyl-cyclohepta-1,4-diene (0.56%) and 7-formyl-4-methyl-cumarine (0.15%) in lovage essential oil is reported. Antibacterial and antifungal activities of mentioned oil were evaluated in vitro on five strains of microorganisms. It was found that lovage volatile oil (L .officinale) exhibits high antibacterial and antifungal properties in the range of concentrations 0.015-0.030%

Chromatographic Analysis of Silybum Marianum (L.) Gaertn. Fatty Oil

The present paper describes biochemical (fatty oil) composition of Silybummarianum (L.) Gaertn. of Moldovan origin. The oil content of the seeds was approximately 25%. Linoleic acid (C18:2), an essential polyunsaturated fatty acid, is the most abundant (48.88%), followed by monounsaturated oleic acid (C18:1, 31.94%) and saturated palmitic acid (C16:0, 7.61%). The RP-HPLC analysis of tocopherols composition, showed as main components α-tocopherol (23.45 mg/100g) and γ–tocopherol (5.60 mg/100g). Based on the obtained results, it was shown that the extracted oil from milk thistle seeds is rich in essential fatty acids (about 50%) and tocopherols (29.09 mg/100g) and it can be used in food preparation

Synthesis of New Homodrimane Sesquiterpenoids Containing Diazine, 1,2,4-triazole and Carbazole Rings

The study describes the synthesis of 11-homodrim-6,8-dien-12-oic acid N-substituted amides containing diazine, 1,2,4-triazole and carbazole rings based on commercially available sclareolide. The mentioned compounds were prepared for the first time by interaction of the generated in situ acyl chloride with some heterocyclic amines: 2- and 4-aminopyrimidine, 2-aminopyrazine, 3-amino-1,2,4-triazole and N-aminocarbazole. Their structures were fully elucidated by elemental and spectral analyses (IR, 1H and 13C NMR)

(-)-DRIMENOL – A VALUABLE STARTING COMPOUND FOR THE SYNTHESIS OF DRIMANIC SESQUITERPENOIDS

(-)-Drimenol is a relatively accessible compound, that has been and may be further used as a starting material to prepare sesquiterpenoids. The present review deals with the methods of obtaining of this compound as well as its usage

SYNTHESIS AND APPLICATION OF THE 11-BISHOMODRIMANE-8α-OL -12-ONE

This review deals the methods of preparation of the 11-bishomodrimane-8α-ol-12-one, a convenient synton for the synthesis of drimanic and bishomodrimanic compounds, including the biologically active ones. The triterpenic tetracyclic derivatives of the onoceranic range and the fragrance compounds with ambergris odour can be also obtained from this compound

SYNTHESIS OF NITROGEN-CONTAINING COMPOUNDS FROM HIGHER TERPENOIDS

The presence of nitrogen in the molecule is usually accompanied either by the appearance of a new activity or the intensification of original activity characteristic for the native terpenoids. This maintains alive the scientific interest in the synthesis of such compounds. The present communication put into discussion the recently elaborated methods for preparation of the nitrogen-containing terpenic compounds

IN MEMORY OF ACADEMICIAN OF ACADEMY OF SCIENCES OF MOLDOVA PROFESSOR CONSTANTIN TURTA

A dedication in memoriam of Academician Constantin Turta, Doctor habilitate in chemistry, Professor, famous scientist, world-renowned chemist, Laureate of the State Prize of the Republic of Moldova, person of a exquisite culture and noble attitude. Scientist Constantin Turta was a worldwide specialist in the field of bioinorganic and coordination chemistry. He became known in the scientific community by his fundamental pioneering work on the application of Mössbauer spectroscopy in inorganic and coordination chemistry. Merits of academician Constantin Turta were appreciated both by the scientific community and the government. He is the Knight of the Order "Labour Glory" and Medal "Dimitrie Cantemir" of the Academy of Sciences of Moldova