2,515 research outputs found
Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis
Objectives: Free radicals play an important role in the onset and progression of many diseases. The aim ofthis study was to investigate the contribution of oxidative stress in the pathology of aggressive (AgP) andchronic (CP) periodontitis and its relation with the clinical periodontal status.Methods: Eighty subjects were divided into two groups: 20 patients with AgP and 20 patients with CP withtheir 20 corresponding matched controls, based on clinical attachment loss (CAL), probing pocket depth(PPD), and bleeding on probing (BOP). Saliva reactive oxygen species (ROS), lipid peroxidation, and nonenzymaticantioxidant defences were measured by luminol-dependent chemiluminescence assay, asthiobarbituric acid-reactive substances (TBARs) and total radical-trapping antioxidant potential (TRAP),respectively. Pearson?s correlation and multivariate analysis were used to determine the relationshipbetween ROS and TBARs and the clinical parameters.Results: ROS and TBARs were increased in AgP while TRAP was decreased, comparing with CP. In AgP, astrong and positive correlation was observed between ROS and TBARs and they were closely associatedwith CAL and PPD.Discussion: In AgP, but not in CP, oxidative stress is a high contributor to periodontal pathology and it isclosely associated with the clinical periodontal status.Fil: Acquier, Andrea Beatriz. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones BiomĂ©dicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones BiomĂ©dicas; ArgentinaFil: de Couto Pita, Alejandra Karina. Universidad de Buenos Aires. Facultad de OdontologĂa. CĂĄtedra de FarmacologĂa; ArgentinaFil: Busch, Lucila. Universidad de Buenos Aires. Facultad de OdontologĂa. CĂĄtedra de FarmacologĂa; ArgentinaFil: Sanchez, Gabriel A.. Universidad de Buenos Aires. Facultad de OdontologĂa. CĂĄtedra de BiofĂsica; Argentin
StakeS-holder Management and Crisis Resilience A case study in a public transportation company
International audienceStakeholder perspectives on crisis management provide a useful descriptive framework for analyzing crises and making crisis narratives. However, their "actionability" for crisis management, i.e. possibility to use stakeholder management models into operational crisis management processes, remains an under-investigated question. The purpose of this article is to discuss the operational value of stakeholder frameworks for crisis management. Drawing on a qualitative case study of a successful crisis management process in a public transportation company, we investigate the activities set up by the crisis cell to manage internal and external stakeholders during the crisis. In our case, successful stakeholder management relied on: 1) good diagnosis capabilities for the design of an appropriate corporate positioning; 2) an ability to manage coherently a set of emerging and heterogeneous issues involving stakeSholders ; 3) the capacity to set up a tightly coupled form of organization, involving both crisis cell members and various "anchorage points", i.e. specific actors involved in the project before the crisis, who were already in contact with key stakeholders as part of their day-to-day activities. We then discuss the practical and theoretical implications of this analysis and the potential value stakeholder perspectives for crisis management
Que peut nous apprendre le courant de la Corporate Social Responsiveness sur les démarches de développement durable des entreprises contemporaines
Working paper serie RMT (WPS 10-10) , 34 pLa recherche gestionnaire dans le champ âBusiness & Societyâ souffre de sa faible prise en compte des enjeux organisationnels et managĂ©riaux associĂ©s aux dĂ©marches dâentreprises en matiĂšre de responsabilitĂ© sociale et de dĂ©veloppement durable. Câest prĂ©cisĂ©ment ce constat qui, dans le courant des annĂ©es 1970, a Ă©tĂ© le point de dĂ©part dâun programme de recherche sur la Corporate Social Responsiveness au sein de la Harvard Business School aux Etats-Unis. Le contenu de ce programme ayant largement Ă©tĂ© oubliĂ© et/ou caricaturĂ©, cet article propose dâen redĂ©couvrir la genĂšse, le contenu et sa portĂ©e, et formule des hypothĂšses sur sa disparition. Il reste pertinent pour lâapprĂ©hension des pratiques contemporaines en matiĂšres de RSE et de DD
PHENIX A Circular Economy Business Model Case
The aim of the R2Ï project is to find and analyze sustainable business models for circular economy in a variety of industrial sectors. Then, it aims to develop propositions that will support such business models. This report develops the case of Phenix, a French company in the food sector, illustrative of a successful circular business model.
Phenix was created in 2014 by two entrepreneurs, Jean Moreau and Baptiste Corval and went through a steady growth, now having 18 regional offices in France and 3 international ones in Copenhagen, Lisbon and Madrid. The companyâs global mission is to âunleash the potential of wasteâ. With an initial focus on food-waste, Phenix has set up a digital platform that works as an intermediary connecting waste âsuppliersâ (mainly retailers) and waste receivers (mostly charities). Through this service, Phenix prevents food close to expiration date from being wasted, and turns such waste into food donations. Beyond its matchmaking platform, Phenix also provides partners with a secured supply chain. Phenix achieves âtriple bottom lineâ value creation, by helping retailers to reduce the cost of food waste (economic benefit), enabling charities to get free access to food donations (social benefit), and helping society to reduce the overall amount of food waste produced in our economic system (environmental & circular economy benefit). It is, therefore, an example of a âmission-driven platformâ, built on a hybrid model that combines business, social and environmental value creation.
Presently, Phenix works with more than a thousand supermarket clients, has 100 full-time employees and helps to distribute over 40 000 meals per day. Phenix business model is circular by design. The organization offers a service to secure the recovery of unsold food products. Doing so, it organizes a circular sourcing for charities and helps retailers managing their products end-of-life. Because Phenix acts as a service provider, it does not generate waste but rather helps other organizations reduce their own.
As a multisided platform, Phenix has developed a distinct pricing scheme to address each side of the platform. Phenix revenue model is based on monetizing the supply-side of the platform, through a fixed commission on the waste-management gains achieved by distributors using the platform. On the other side of the platform (demand side), Phenix organizes free access to food for social charities, thus achieving a social benefit and facilitating the growth of the platform.
The French legal framework offered a favorable context for the development of a profitable business model for Phenix. As part of this regulatory framework, an existing tax incentive introduced in 1981 under the âColuche lawâ providing for a 60% tax deduction for food retailers and producers who donate foodstuffs instead of generating waste. Through its secured supply chain, Phenix organizes traceability, secures savings for retailers and can charge a commission on the total savings on waste management, making the business model viable.
As a fast growing and profitable start-up, the company is currently exploring different opportunities for geographical diversification in other European and non-European countries. The company is also currently engaged in processes of horizontal diversification to expand its services to new types of waste, and explores how to improve its current offer through digital solutions.
While the company strategic position appears quite robust, few points of attention need to be considered: the business model remains dependent on favorable regulations, it remains labor intensive and new market acquisitions require large investments. Yet, new technology such as big data or IoT can radically improve the modelâs cost-efficiency. Lobbying skills and network effects can protect the regulatory framework and diversification strategy to other resources (non-food wastes) and new skills (consulting) can strengthen the business model.
Beyond the strategic analysis of the company, this case study has significant implications for public regulators. It first highlights the central role of public regulation in the innovation process. And it illustrates the hypothesis of Porter and Van der Linde, according to which properly crafted environmental regulations not only help to reduce environmental externalities, but they can also lead to profits for innovative companies (Porter & Linde, 1995). Overall our results points toward a mix between a regulatory framework and private dynamics of innovation to create successful circular business model. On the innovation side, the case shows how mission-driven platforms can reconfigure stakeholder relations in a given business ecosystem and improve operational efficiency of these relations in order to decrease waste and increase re-useThis project has received funding from the European Unionâs Horizon 2020 research and innovation programme under grant agreement No. 73037
Standards and innovation in emerging fields: Pushing breakthrough innovation or enrolling actors? An analysis of eco-district standards in France and Denmark
International audienceStandards and norms are central objects for institutional studies. However, their role in innovation and the creation of novelty remain unclear, in particular in new / emerging fields. Accordingly, this paper investigates the relationship between standard setting and innovation, in the context of emerging organizational fields. We consider standardization in emerging fields as a socio-technical process, which must simultaneously promote a certain degree of innovation and enroll actors in order to succeed. We apply this perspective to compare standardization processes in the field of eco-districts, both in France and Denmark. Our analysis reveals different tensions, tradeoffs and priorities, among standards, between enrolment priorities, and the need to push forward technical innovation. We discuss how the two issues of constraints and enrollment can be articulated and combined
La prose dâidĂ©es espagnole et le paradigme de lâĂ©conomie domestique ou lâĂ©conomie dans la littĂ©rature (XVIe-XVIIe siĂšcles)
Cette Ă©tude tente dâapprocher le sens et les enjeux de la prĂ©sence du paradigme de lâĂ©conomie domestique dans la prose dâidĂ©es espagnole, en particulier dans la littĂ©rature nobiliaire et « économique » du siĂšcle dâor espagnol. Inclus dans le vaste champ de la philosophie morale dont lâhistoire ramĂšne aux sources antiques et mĂ©diĂ©vales, le gouvernement de la maison (sens Ă©tymologique du terme « économie ») peine Ă sâabstraire, dans les textes de cette « littĂ©ratures dâidĂ©es », dâune chaĂźne conceptuelle analogique structurante qui la situe entre le gouvernement de la rĂ©publique (politique) et le gouvernement de soi (Ă©thique). Or Ă lâĂąge classique, la littĂ©rature est traversĂ©e par des tensions paradoxales qui lui permettent de conserver son rĂŽle de creuset de tous les savoirs mais en mĂȘme temps la conduisent Ă favoriser lâautonomisation progressive -mais jamais linĂ©aire- des diffĂ©rents champs de la connaissance. Lâarticle prĂ©sentĂ© sâattache Ă faire la part entre les adaptations gĂ©nĂ©riques inventĂ©es par la prose dâidĂ©es pour sâapproprier ces savoirs, lâinstrumentalisation dans les discours de lâinclusion de lâ« économie » dans la philosophie morale Ă des fins de stratĂ©gies sociales (individuelles) ou catĂ©gorielles (collectives) et les glissements Ă©pistĂ©mologiques que cela suppose. En passant par les strates de lâanalyse gĂ©nĂ©rique, socio-historique et Ă©pistĂ©mologique dâun Discours Ă©conomique (1652) dĂ» Ă Antonio LĂłpez de Vega, ce travail tente de mettre en valeur la promotion dâune « économie moralisĂ©e », qui jette les bases dâune possible Ă©volution de lâ« économie domestique » dĂ©passant la gestion et lâadministration de la maison.El presente estudio intenta medir la significaciĂłn del paradigma de la economĂa domĂ©stica en la prosa de ideas española, en particular en la literatura nobiliaria y econĂłmica del siglo de oro español. Incluido en el amplio campo disciplinar de la filosofĂa moral, cuya historia echa raĂces en las fuentes antiguas y medievales, la nociĂłn de gobierno de la casa (sentido etimolĂłgico del tĂ©rmino « economĂa ») no puede separarse sino con dificultad de una cadena analĂłgica y estructurante de conceptos que la sitĂșa entre el gobierno de la repĂșblica (polĂtica) y el gobierno de sĂ mismo (Ă©tica). Ahora bien, en la literatura de edad clĂĄsica obran unas tensiones paradĂłjicas que le permiten seguir cumpliendo su papel de crisol de todos los saberes, pero que al tiempo, favorecen en ella la autonomizaciĂłn progresiva â nunca lineal â de los diferentes ĂĄmbitos del conocimiento. Este artĂculo procura valorar las adaptaciones genĂ©ricas inventadas por la prosa de ideas para adueñarse de estos saberes, la manera como los discursos se valen de la totalidad del paradigma de la filosofĂa moral con fines sociales individuales o colectivas y los acomodos epistemolĂłgicos consiguientes. BasĂĄndonos en el anĂĄlisis genĂ©rico, socio-histĂłrico y epistemolĂłgico de un Discurso econĂłmico (1652)redactado por Antonio LĂłpez de Vega, hacemos hincapiĂ© en la promociĂłn de una « economĂa moralizada », como posible superaciĂłn de la nociĂłn de economĂa domĂ©stica
Avant-propos. Prose dâidĂ©es, prose de pensĂ©e, un bilan
Le numĂ©ro 14 des Cahiers de narratologie prĂ©sente les travaux effectuĂ©s en 2006 et 2007 par le groupe interdisciplinaire « Textes et prose dâidĂ©es », crĂ©Ă© en 2005 au sein du CIRCPLES-EA 3159. Ce groupe rassemble des spĂ©cialistes de littĂ©rature, de civilisation, dans les domaines de lâEspagne moderne, de lâItalie et de la France contemporaines. Il se propose dâĂ©tudier les textes relevant de la prose dâidĂ©es inscrite dans un cadre chronologique, gĂ©ographique et culturel ouvert. Les premiers tr..
Présentation : soif de mots, désir de science. Quelques aspects de la relation entre littérature et science(s)
La prĂ©sente livraison des Cahiers de narratologie sâintĂ©resse aux rapports complexes quâentretiennent littĂ©rature et sciences. Elle est le fruit dâun sĂ©minaire qui a eu lieu pendant deux ans, entre janvier 2008 et dĂ©cembre 2009, dans le cadre du groupe de recherche « Prose dâidĂ©es, littĂ©rature dâidĂ©es » au sein du CIRCPLES et dâune journĂ©e dâĂ©tude organisĂ©e en octobre 2008 sur le thĂšme « littĂ©rature et mĂ©decine ». Au regard de la rĂ©novation de lâhistoriographie sur lâinteraction entre littĂ©ra..
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