9 research outputs found
The Analgesic and Anti-Inflammatory Activities of the Extracts of Phyllanthus reticulatus in Mice Model.
ABSTRACT The extract of the bark of Albizia lebbeck Benth. obtained by cold extraction of mixture of equal proportions of petroleum ether, ethyl acetate and methanol was chosen for pharmacological screening. In rat paw edema model induced by carrageenan, the extract at the 400 mg/kg dose level showed 36.68% (p<0.001) inhibition of edema volume at the end of 4h. In the acetic acid-induced writhing test, the extract at the 200 and 400 mg/kg dose level showed 39.9 % and 52.4 % inhibition of writhing, respectively. In radiant heat tail-flick method the crude extract produced 40.74% (p<0.001) and 61.48% (p<0.001) elongation of tail flicking time 30 minutes after oral administration at the 200 and 400 mg/kg dose level, respectively
Anti-inflammatory activity of bark of Xeromphis spinosa
The bark of Xeromphis spinosa extracted by a mixture of equal proportions of petroleum ether, ethyl acetate and methanol at an oral dose of 200 and 400 mg/kg body weight exhibited significant anti-inflammatory activity when compared with control
Paw edema
The bark of Xeromphis spinosa extracted by a mixture of equal proportions of petroleum ether, ethyl acetate and methanol at an oral dose of 200 and 400 mg/ kg body weight exhibited significant anti-inflammatory activity when compared with control
Effect of Metformin, Rapamycin, and Their Combination on Growth and Progression of Prostate Tumors in HiMyc Mice
Bioactive Alkaloid from Sida cordifolia  Linn. with Analgesic and Anti-Inflammatory Activities
In the present study, the analgesic and anti-inflammatory activities of
a new alkaloid (5'-Hydroxymethyl-1'-(1,2,3,9-tetrahydro-pyrrolo [2,1-b]
quinazolin-1-yl)-heptan-1-one) (compound 1), isolated from Sida
cordifolia  Linn. was investigated in animal models. The
analgesic activity was investigated in the acetic acid induced writhing
and the radiant heat tail flick model in mice and the carrageenan
induced rat paw edema model was used for anti-inflammatory study. The
compound produced significant (p<0.01) analgesic activity in both
models. The compound also exhibited significant (p<0.01) inhibition
of rat paw edema induced by carrageenan. These results indicated that
compound 1 possessed analgesic and anti-inflammatory activities