ANTIULCER ACTIVITY OF AMARANTHUS SPINOSUS LEAF EXTRACT AND ITS COMPARISION WITH FAMOTIDINE IN SHAY RATS

Anti-ulcer activities of petroleum ether, chloroform, Ethanolic extract of Amaranthus spinosus leaf were tested for anti-gastric ulcer activity in Shay rat model. Oral dose of 400mg/kg of ethanolic extract reduced the ulceration and with 800mg/kg body weight ethanolic extract there is the complete absence of ulceration. The anti-gastric activity of ethanolic extract of A.spinosus 800mg/kg body weight was found to be equal to the effect produced by 2mg/kg of Famotidine orally. The reduction in gastric activity was more with Famotidine and the reduction in peptic activity is more with ethanolic extract of A.spinosus. All extracts are safe up to 4000mg/kg. The result of petroleum ether, chloroform and aqueous extract in respect of anti-ulcer activity are less prominent. Keywords: Amaranthus spinosus, Shay rat model, Famotidine, Peptic activityÂ