The cytotoxic evaluation of mineral trioxide aggregate and bioaggregate in the subcutaneous connective tissue of rats

Objectives: The purpose of this study was to evaluate and compare the cytotoxic effects of ProRoot MTA and DiaRoot BA, a bioceramic nanoparticulate cement, on subcutaneous rat tissue. Study D esign: Fifty Sprouge Dawley rats were used in this study. Polyethylene tubes filled with ProRoot MTA and DiaRoot BioAggregate, along with a control group of empty, were implanted into dorsal connective tissue of rats for 7, 15, 30, 60, and 90 days. After estimated time intervals the rats were sacrificed. The specimens were fixed, stained with hematoxylin and eosin, and then evaluated under a light microscope for inflammatory reactions and mineralization. Results: All groups evoked a severe to moderate chronic inflammatory reaction at 7 and 15 days, which decreased with time. Both the MTA and BioAggregate groups showed similar inflammatory reactions, except at 90 days when MTA showed statistically significant greater inflammation (p>0.05). The MTA group showed foreign body reaction at all times. Compared to BioAggregate, MTA showed significantly more foreign body reaction at 60 and 90 days (p<0.0001). After 30 days foreign body reaction of BioAggregate decreased significantly. Both MTA and BioAggregate groups showed similar necrosis at 7 and 15 days (p=0.094 and p=0.186 respectively). No necrosis was observed after 15 days. Similarly there was no fibrosis after 30 days for both MTA and BioAggregate groups (p>0.05). Conclusions: Since DiaRoot BioAggregate showed significantly better results than MTA, we can conclude that it is more biocompatible. However, further studies are required to confirm this result

Structure-revealing data fusion

BACKGROUND: Analysis of data from multiple sources has the potential to enhance knowledge discovery by capturing underlying structures, which are, otherwise, difficult to extract. Fusing data from multiple sources has already proved useful in many applications in social network analysis, signal processing and bioinformatics. However, data fusion is challenging since data from multiple sources are often (i) heterogeneous (i.e., in the form of higher-order tensors and matrices), (ii) incomplete, and (iii) have both shared and unshared components. In order to address these challenges, in this paper, we introduce a novel unsupervised data fusion model based on joint factorization of matrices and higher-order tensors. RESULTS: While the traditional formulation of coupled matrix and tensor factorizations modeling only shared factors fails to capture the underlying structures in the presence of both shared and unshared factors, the proposed data fusion model has the potential to automatically reveal shared and unshared components through modeling constraints. Using numerical experiments, we demonstrate the effectiveness of the proposed approach in terms of identifying shared and unshared components. Furthermore, we measure a set of mixtures with known chemical composition using both LC-MS (Liquid Chromatography - Mass Spectrometry) and NMR (Nuclear Magnetic Resonance) and demonstrate that the structure-revealing data fusion model can (i) successfully capture the chemicals in the mixtures and extract the relative concentrations of the chemicals accurately, (ii) provide promising results in terms of identifying shared and unshared chemicals, and (iii) reveal the relevant patterns in LC-MS by coupling with the diffusion NMR data. CONCLUSIONS: We have proposed a structure-revealing data fusion model that can jointly analyze heterogeneous, incomplete data sets with shared and unshared components and demonstrated its promising performance as well as potential limitations on both simulated and real data. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2105-15-239) contains supplementary material, which is available to authorized users

Werbetexte Im Interkulturellen Vergleich. Eine Kontrastive und Linguistische Studie Zu Werbetexten Aus Dem Deutschen und Türkischen

Acceleration of international trade has led to the development of international marketing. Different cultural structures of international markets have necessitated modifying the marketing strategies and commercials of companies. Today, commercials become more and more important. The main purpose of commercials is to make sure that the publicized product is purchased by the target audience. However, presentation of the commercials is also significant, in order to ensure purchasing.Although it appears today as if the number of people who consumes the same products and who adopts similar lifestyles has increased, this common market actually consists of various people and cultures. Cultural values of societies are offered to the audience through visual coding and a connection is established with the audience, so that the message achieves its goal. Images, therefore, assume a semiotic function in creating a meaning. International companies turn towards national campaigns more than the intUluslararası ticaretin hız kazanması, uluslararası pazarlamanın gelişmesini de sağlamıştır. Uluslararası pazarların sahip olduğu farklı kültürel yapılar, firmaların pazarlama stratejilerini ve reklamlarını değiştirmeyi zorunlu hale getirmiştir. Reklamlar, günümüzde önemini giderek arttırmaktadır. Reklamların temel amacı, reklamı yapılan ürünün hedef kitle tarafından satın alınmasını sağlamaktır. Ancak satın almayı sağlamak için, reklamların nasıl sunulduğu da önemlidir.Günümüzde aynı ürünleri tüketen, aynı yaşam tarzlarını benimseyen insanların sayısı artmış gibi gözükse de, aslında bu ortak pazar çok farklı insanlardan ve kültürlerden oluşmaktadır. Toplumların kültürel değerleri, görsel kodlamalar aracılığıyla izleyiciye sunulur, mesajın amacına ulaşması için izleyiciler ile bir bağ kurulur. Böylece, görüntüler, anlamın oluşmasında gösterge bilimsel bir işlev üstlenir. Uluslararası firmalar, uluslararası kampanyalardan çok ulusal kampanyalara yönelmektedir, çünkü her pazarın ihtiya

Carrickmacross Dantelleri ve İğne Oyalarıyla Uygulama Örneğinde Tekstil ve Lif Sanatı Kavramlarına Bir Bakış

Geleneksel el sanatlarının bir dalı olarak dantel, dünya üzerinde ait olduğu coğrafya ile şekillenen, kültürlerin gelenekler ile aktarımında bir araçhaline gelen, özenli ve oldukça zahmetli bir el sanatıdır. Bu çalışmalar herne kadar geleneksel olarak nitelendirilseler de yeni yaklaşımlar ile güncelyorumlar kazandırılarak farklı alanlarda örnekler sunmaktadırlar. Carrickmacross dantelleri, Avrupa dantelleri arasında yer alan, Sanayi Devrimisonrasında makinede üretimi de sağlanmış olan bir çeşit aplike dantel olarak değerlendirilen İrlanda’ya özgü nakışlı çalışmalardır. Bu çalışma sürecinde makine üretimi sayesinde günümüz tekstil sektöründe yaygın olarakbilinen Carrickmacross danteli ile nispeten daha az tanınan Anadolu kültürünün önemli bir el sanatı olan iğne oyası tekniğiyle özgün bir uygulamagerçekleştirilmiştir. Makale çalışmasının amacı, ele alınan teknikleri asıl işlevlerinden izole ederek değerlendirmek üzere detaylı şekilde araştırıp,deneyimlemek ve gerçekleştirilen uygulama üzerinden, geleneksel tekstiltekniklerinin yorumlanması sonucu üretilen objeleri plastik ifadelerinin kategorileri açısından yoruma açmaktır. Geleneksel üretim yöntemlerinin zanaattan beslenerek, evrensel bir yaklaşımla yeniden ele alınması çalışmanınbir diğer amacıdır.&nbsp;Lace art, which is a branch of conventional handicrafts, is a detailed and laborious handicraft that is shaped by the geography it belongsto, and has become a tool in the transfer of cultures with customs. Althoughthese craft works have been described as conventional, they can provideexamples in different fields by gaining up-to-date interpretations with newapproaches. Carrickmacross laces are, as a part of Irish culture, embroidered works that are among the European laces, started to be produced byCarrickmacross Dantelleri ve İğne Oyalarıyla Uygulama Örneğinde Tekstil ve ... 278Kesit Akademi Dergisi - The Journal of Kesit AcademyYıl/Year/Год: 8, Sayı/Number/ Номер: 31, Haziran/June/Июнь 2022machines after the Industrial Revolution and are claimed as a kind of applique lace. In this design process, Carrickmacross lace, which is an accomplishment of machine production and is widely known in the textile industry, and needle lace technique, which is an significant handicraft of the Anatolian culture, were used together, and as a result, an unique work of artwas created. The fundamental motivation behind the article is to investigate and experience the techniques in order to evaluate them by isolatingthem from their main functions, and to open the objects produced by theinterpretation of traditional textile techniques to interpretation in terms ofthe categories of plastic expressions. Another purpose of the article is tofeed traditional production methods from the craft and reevaluate themwith a universal approach.</p

Purification and partial characterization of thioredoxin reductase from the hepatopancreas of the mollusc Mytilus galloprovincialis Lam.

Thioredoxin reductase (TrxR, EC 1.6.4.5) is a ubiquitous flavoenzyme that is present from Archaea to humans, and it is the only enzyme capable of catalyzing the reduction of thioredoxin (Trx) by nicotinamide adenine dinucleotide phosphate (NADPH). Although TrxR has been purified and characterized from different bacteria, plants, and mammalian organisms, a survey of the literature revealed no studies on the purification and characterization of TrxR from the mussel Mytilus galloprovincialis Lam. In this study, TrxR was purified to homogeneity from the hepatopancreatic tissue of M. galloprovincialis Lam. by extraction, ammonium sulfate precipitation, and DEAE-Sepharose CL-6B anion and 2', 5'-ADP-agarose chromatographies, and some of its kinetic properties were examined. Molar mass determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed only a single protein band corresponding to a molecular weight of 35 kDa. Optimum pH and temperature were found to be 7.0 and 60 degrees C, respectively. Km and Vmax values for NADPH were found to be 85 mu mol and 4.82 mu mol/min/mg, respectively. For 5,5'-dithiobis (2-nitrobenzoic) acid (DTNB), the Km and Vmax values were 193 mu mol and 1.32 mu mol/min/mg, respectively. Increasing the knowledge on the kinetic properties of TrxR will significantly increase the prospects of enzyme application as an oxidative stress biomarker in mussels and fishes for monitoring contamination in coastal environments