Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients

Background Advanced glycation end products (AGEs) are associated with aging, diabetes mellitus (DM), and other chronic diseases. Recently, the accumulation of AGEs can be evaluated by skin autofluorescence (SAF). However, the relationship between SAF levels and exercise capacity in patients with cardiovascular disease (CVD) remains unclear. This study aimed to investigate the association between the tissue accumulation of AGEs and clinical characteristics, including exercise capacity, in patients with CVD. Methods We enrolled 319 consecutive CVD patients aged >= 40 years who underwent early phase II cardiac rehabilitation (CR) at our university hospital between November 2015 and September 2017. Patient background, clinical data, and the accumulation of AGEs assessed by SAF were recorded at the beginning of CR. Characteristics were compared between two patient groups divided according to the median SAF level (High SAF and Low SAF). Results The High SAF group was significantly older and exhibited a higher prevalence of DM than the Low SAF group. The sex ratio did not differ between the two groups. AGE levels showed significant negative correlations with peak oxygen uptake and ventilator efficiency (both P <0.0001). Exercise capacity was significantly lower in the high SAF group than in the low SAF group, regardless of the presence or absence of DM (P <0.05). A multivariate logistic regression analysis showed that SAF level was an independent factor associated with reduced exercise capacity (odds ratio 2.10; 95% confidence interval 1.13-4.05; P = 0.02). Conclusion High levels of tissue accumulated AGEs, as assessed by SAF, were significantly and independently associated with reduced exercise capacity. These data suggest that measuring the tissue accumulation of AGEs may be useful in patients who have undergone CR, irrespective of whether they have DM

Diurnal Variation Characteristics of Summer Precipitation and Related Statistical Analysis in the Ili Region, Xinjiang, Northwest China

The diurnal variation characteristics and basic statistical features of summer precipitation (from June to August) in the Ili region from 2015 to 2019 were investigated based on 4 km resolution Weather Research and Forecasting model simulation data from Nanjing University (WRF_NJU). The results show that the overall diurnal variation characteristics of precipitation (DVCP) reflected by the WRF_NJU data were consistent with respect to the observations and reanalysis data. The total precipitation pattern exhibited high (low) values on the east (west), with higher (lower) values over the mountainous (valley) area. Hourly precipitation amount (PA), precipitation frequency (PF), and precipitation intensity (PI) show similar diurnal variation characteristics, with peaks occurring at around 1700 LST in the mountainous area and around 2000 LST in valleys. Furthermore, moderate to intense precipitation contributes up to 87.88% of the total precipitation. The peaks in the mountainous area occur earlier than the valleys, while the peaks in western part of the valleys occur earlier than the eastern part. The PA peaks over the valleys and slopes occurred from the evening to early morning and from the afternoon to evening, respectively. In addition, the rotated empirical orthogonal function (REOF) analysis implied that the DVCP exhibits distinct differences between mountainous and valleys, and peak precipitation occurs during the evening in basin– and wedge–shaped areas, while the mountain peaks and foothill regions exhibit semi–diurnal variation characteristics. Among several basic meteorological factors, the vertical velocity (VV) and water vapor mixing ratio (WVMR) provided major contributions to the DVCP in both areas with high and low coefficients of variation, and the WVMR (VV) probably played a more significant role in mountainous (valleys) areas