9 research outputs found
Impaired fatty acid oxidation in muscle of aging rats perfused under basal conditions
- Publication venue
- 'American Physiological Society'
- Publication date
- Field of study
Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice
- Publication venue
- American Physiological Society
- Publication date
- Field of study
Aging presumably initiates shifts in substrate oxidation mediated in part by changes in insulin sensitivity. Similar shifts occur with cardiac hypertrophy and may contribute to contractile dysfunction. We tested the hypothesis that aging modifies substrate utilization and alters insulin sensitivity in mouse heart when provided multiple substrates. In vivo cardiac function was measured with microtipped pressure transducers in the left ventricle from control (4–6 mo) and aged (22–24 mo) mice. Cardiac function was also measured in isolated working hearts along with substrate and anaplerotic fractional contributions to the citric acid cycle (CAC) by using perfusate containing 13C-labeled free fatty acids (FFA), acetoacetate, lactate, and unlabeled glucose. Stroke volume and cardiac output were diminished in aged mice in vivo, but pressure development was preserved. Systolic and diastolic functions were maintained in aged isolated hearts. Insulin prompted an increase in systolic function in aged hearts, resulting in an increase in cardiac efficiency. FFA and ketone flux were present but were markedly impaired in aged hearts. These changes in myocardial substrate utilization corresponded to alterations in circulating lipids, thyroid hormone, and reductions in protein expression for peroxisome proliferator-activated receptor (PPAR)α and pyruvate dehydrogenase kinase (PDK)4. Insulin further suppressed FFA oxidation in the aged. Insulin stimulation of anaplerosis in control hearts was absent in the aged. The aged heart shows metabolic plasticity by accessing multiple substrates to maintain function. However, fatty acid oxidation capacity is limited. Impaired insulin-stimulated anaplerosis may contribute to elevated cardiac efficiency, but may also limit response to acute stress through depletion of CAC intermediates
Lipid intermediates in chronically volume-overloaded rat hearts
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Physicochemical characterization of an aspin (rBm-33) from a filarial parasite Brugia malayi
- Author
- Abu-Erreish GM
- Bennett K
- Christeller JT
- Craig C
- Dame JB
- Dissanayake S
- K. Gunasekaran
- Kageyama T
- Kageyama T
- Kageyama T
- Kreft S
- Krishna NR
- Krushna NS
- Krushna NS
- Martzen MR
- Monod M
- Moon RP
- N. S. A. Krushna
- Nagampalli Raghavendra Sashi Krishna
- Ohnshi H
- Ohnshi H
- Petersen W
- R. B. Narayanan
- Rich DH
- S. S. Rajan
- Saheki T
- Takahashi S
- Wetzel R
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Thyroid Hormone Reverses Aging-Induced Myocardial Fatty Acid Oxidation Defects and Improves the Response to Acutely Increased Afterload
- Author
- Aaron K. Olson
- AM Kates
- B Biondi
- B Biondi
- B Biondi
- B Gencer
- BN Finck
- C Pantos
- CR Malloy
- D Rohrer
- Dolena Ledee
- DP Koonen
- EG Lakatta
- F Monzani
- FM Jeffrey
- GM Abu-Erreish
- I Klein
- J Shirani
- J Vandesompele
- JB McMillin
- JJ Krueger
- JJ Lehman
- Masaki Kajimoto
- Michael A. Portman
- Nancy Isern
- OM Hyyti
- OM Hyyti
- OM Hyyti
- S Fazio
- S Lloyd
- S Neubauer
- SC Kolwicz Jr
- WC Stanley
- Wolf-Hagen Schunck
- YF Chen
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Heart failure and the aging myocardium: Possible role of cardiac mitochondria
- Author
- A Arduini
- A Bakker
- A Koizumi
- A Slater
- AM Feldman
- AR Heydari
- B Bandy
- D Harman
- D. Hegner
- DC Wallace
- DR Johns
- E Xia
- EA Faulk
- EG Lakatta
- EG Lakatta
- EJ Lesnefsky
- EL Tate
- ES Weistein
- FL Hoch
- G Cortopassi
- G Gaines
- G Olivetti
- G Paradies
- G Paradies
- G Paradies
- G Paradies
- G Rao
- G Schatz
- GA Cortopassi
- GA Cortopassi
- GH Herbener
- GM Abu-Erreish
- GM Abu-Erreish
- GT Schuyler
- H Nohl
- H Nohl
- HN Sabbah
- J Müller-Höcker
- JA Chesky
- JA Chesky
- JA Odiet
- JB McMillin
- JC Chen
- JK Gwathmey
- JM Duan
- JS Ingwall
- JS Ingwall
- JW Palmer
- JW Palmer
- JW Starnes
- JW Starnes
- JY Wei
- JY Wei
- JY Wei
- JY Wei
- JY Wei
- K Ataka
- K Hannavy
- K Hattori
- K Schwartz
- KR Ryan
- L Piko
- LA Grivell
- LC Stewart
- LL Ji
- LL Ji
- LMZ Maciel
- M Costell
- M Costell
- M Takasawa
- MB Lewin
- ME Christe
- MF Allard
- MJ Sullivan
- MN Gadaleta
- MS Manzelmann
- P Buttrick
- P Seibel
- R Coleman
- R Ferrari
- R Hachamovitch
- R Weindruch
- R Weindruch
- RG Hansford
- RG Hansford
- RG Hansford
- RJ Luchi
- RJ Tomanek
- RS Sohal
- S Isoyama
- S Isoyama
- S Laganiere
- T Takashashi
- TA Luhtala
- V Regitz
- W Johnston
- WC Orr
- YX Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Characterization of a novel aspartyl protease inhibitor from Haemonchus contortus
- Author
- A Cope
- A Jolodar
- A Taylor
- AP Yatsuda
- Baojie Li
- C Dash
- C Yuan
- CI Muleke
- D Yi
- DL Emery
- E Moreau
- EN Meeusen
- F Alba-Hurtado
- F Wang
- G Zhao
- GF Newlands
- GM Abu-Erreish
- GP White
- GQ Zhang
- J WillenbĂĽcher
- Javaid Ali Gadahi
- K Han
- KJ Livak
- KP Shakya
- Lixin Xu
- M Kudo
- MA Munoz-Guzman
- MC Santos
- MK Levings
- MM Bradford
- MS Duffy
- Muhammad Ehsan
- N Bakker
- P Geldhof
- R Prichard
- RJ Riese
- RJ Shaw
- RK Grencis
- RM Anthony
- RM Maizels
- Ruofeng Yan
- S Nikolaou
- SE Newton
- SJM Jones
- SM Coomes
- T Kageyama
- V Maere De
- V Mcdonald
- W Wang
- Wenxiang Gao
- Xiangrui Li
- Xiaokai Song
- Y Murata
- Z Zhang
- Zhenchao Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Age-Related Changes in Left Ventricular/Arterial Coupling
- Author
- A Granath
- AJ Linzbach
- AP Avolio
- AP Avolio
- AP Avolio
- AR Moritz
- BL Nielsen
- BM Learoyd
- CJ Mills
- CJ Pepine
- CJ Pepine
- CS Roy
- CW Urschel
- DA McDonald
- DD O’Keefe
- DEL Wilcken
- DHR Mowat
- DJ Mozersky
- DJ Patel
- DL Newman
- DV Unverferth
- E Cleary
- E Simonson
- ED Freis
- EG Lakatta
- ER Gozna
- ES Imperial
- FA Mahomed
- FA Mahomed
- FA Mahomed
- FCP Yin
- FCP Yin
- FCP Yin
- FCP Yin
- G Elzinga
- G Gerstenblith
- G Gerstenblith
- GC Bos Van den
- GH Templeton
- GJ Langewouters
- GM Abu-Erreish
- GM Fischer
- GM Hass
- H Bader
- H Bafitis
- H Pouleur
- H Wolinsky
- HB Butcher
- HD O’Kane
- HR Guard
- HZ Movat
- I Mirsky
- JC Bramwell
- JC Bramwell
- JC Bramwell
- JC Rembert
- JM Gardin
- JN Cohn
- JP Merillon
- JP Murgo
- JP Murgo
- JP Murgo
- JP Murgo
- JT Apter
- K Chattergee
- K Sagawa
- K Sunagawa
- LA Sordahl
- LH Peterson
- M Beznak
- M Brandfonbrener
- M Eliakim
- M Faber
- M Landowne
- M Roach
- MA Quinones
- MF O’Rourke
- MF O’Rourke
- MF O’Rourke
- MF O’Rourke
- MF O’Rourke
- MF O’Rourke
- MF O’Rourke
- MF O’Rourke
- MF O’Rourke
- MF O’Rourke
- MF O’Rourke
- MG Taylor
- MIM Noble
- ML Weisfeldt
- MLR Harkness
- N Ishide
- N Westerhof
- NW Shock
- O Auerbach
- OHL Bing
- P Hallock
- P Hallock
- PF Salisbury
- R Cotton
- RA Milch
- RA Schatz
- RG Monroe
- RH Cox
- RJ Gray
- RJ Puls
- RR Miller
- S Julius
- S Koyanagi
- S Port
- SJ Sarnoff
- SM Finkelstein
- T Nakashima
- T Young
- TM Mueller
- TR Harrison
- U Gessner
- VC Myers
- W Gundel
- W Schimmler
- W Westerhof
- WB Kannel
- WE Stehbens
- WE Walker
- WR Milnor
- WR Milnor
- WR Milnor
- WW Nichols
- WW Nichols
- WW Nichols
- WW Nichols
- WW Nichols
- WW Nichols
- WW Nichols
- WW Nichols
- Z Ben-Ishay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1987
- Field of study
Enzyme Handbook
- Author
- 339-349
- [10]Siffert O., Emöd, I.
- [11] Fricker L.D., Snyder, S.H.
- [11] Taylor A., Volz, K.W., Lipscomb, W.N., Takemoto, L. J.
- [3] Schmidt U., Weller, D., Holder, A.
- [9]Fujiwara K., Tsuru, D.
- [hie J.N., Dure, L.S.
- A Amory
- A Baccarini-Melandri
- A Barth
- A Beaumont
- A Benajiba
- A Björklind
- A Björklind
- A Bourne
- A Carne
- A Cunningham
- A Dubin
- A Ducruix
- A Endo
- A Enyedi
- A Fujiwara
- A Gladhaug
- A Goffeau
- A Goffeau
- A Grubb
- A Guranowski
- A Guranowski
- A Guranowski
- A Hachimori
- A Hachimori
- A Hanck
- A Hasilik
- A Hasilik
- A Hiramatsu
- A Hui
- A Ichikawa
- A Impoolsup
- A Impoolsup
- A Iwayama
- A Journet
- A Kato
- A Kiener
- A Kilara
- A Kishimoto
- A Kitahara
- A Koheil
- A Koide
- A Kornberg
- A Kumon
- A Lauwers
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Lecroisey
- A Light
- A Light
- A Light
- A Light
- A Manthey
- A Marquet
- A Melo
- A Merta
- A Moreno
- A Moriyama
- A Moriyama
- A Murai
- A Nicholson-Weller
- A Nordwig
- A Nordwig
- A Okitani
- A Okitani
- A Okitani
- A Ota
- A Pierre
- A Pähler
- A Radzicka
- A Reboul
- A Reboul
- A Rinne
- A Ritonja
- A Rosenberg
- A Sancar
- A Sharma
- A Soumarmon
- A Stockell
- A Storer
- A Suhar
- A Suzuki
- A Suzuki
- A Szewczuk
- A Szewczuk
- A Taylor
- A Taylor
- A Thomson
- A Traverso-Cori
- A Wolos
- A Wolos
- A Wolos
- A Yaron
- A Yaron
- A Yaron
- A Yaron
- A Yawetz
- A Yiotakis
- A-C Ryden
- A-M Gilles
- A-M Gilles
- A-M Gilles
- A-M Lacoste
- AA Kortt
- AA Kortt
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- AA Lodice
- AA Patchett
- AA Swanson
- AA Swanson
- AA Taylor
- AB Bennett
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- AC Roy
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- ACM Camargo
- AD Gounaris
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- AE Davies
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- AR Beaudoin
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- AS Balasubramanian
- ATP Skrabanja
- AV Hoffbrand
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- AZ Eisen
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- B Asgeirsson
- B Bauvois
- B Foltmann
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- B Pope
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- B Sprössler
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- B Tomkinson
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- BA Mcmullen
- BC Furie
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- BF Edwards
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- BY Hiraoka
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- C Bordallo
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- C Zwizinski
- C-H Wong
- C-M Lee
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- CH Miller
- Chan. S.A.T., Jones, T.H.D., Sweeney, J.P., Toursarkissian, K.
- Chih-Min Kam Fujikawa, K.
- CJ Brandl
- CJ Chern
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- CO Piggott
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- D Barrett
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- Xin-Ii Lin Wong, R.N.S., Tang, J.
- Y Agrawal
- Y Agrawal
- Y Atsumi
- Y Bai
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- Y Ethoh
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- “ (Turk V., Neville, M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1991
- Field of study