Salicylsalicylic acid causes less gastroduodenal mucosal damage than enteric-coated aspirin

The gastroduodenal mucosal damage caused by aspirin and nonsteroidal antiinflammatory drugs is a common clinical problem. We compared two medications designed to diminish mucosal damage: enteric-coated aspirin and salicylsalicylic acid (salsalate). Ten healthy volunteers were randomized to receive either 1.5 g salsalate twice a day or 650 mg enteric-coated aspirin four times a day for six days and were then crossed over to the other drug after a one-week medication-free period. Endoscopic inspection of gastroduodenal mucosa was performed at entry and again after six days of drug therapy for each medicine. Mean serum salicylate concentrations taken before the morning drug dose were 11.2 mg/dl for enteric-coated aspirin and 18.1 mg/dl for salsalate. Only one of 10 subjects receiving salsalate developed mild (grade 1) mucosal damage while six of 10 receiving enteric-coated aspirin developed moderate to severe damage (grade 2–3) (P= 0.01 ). Symptoms were mild in both groups. We conclude that salsalate causes less gastroduodenal mucosal damage than enteric-coated aspirin .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44409/1/10620_2005_Article_BF01536056.pd

Searching for Legitimacy in the telecommunications industry: evidence from a case study

This paper is the result of an intensive, in-depth case study in a Portuguese telecommunications firm (Marconi), which, with the liberalisation of the national and European telecommunications industries, was pressured to change its management accounting system (MAS). Both institutional and economic forces lay behind the profound changes that occurred in Marconi's MAS. An interpretive theoretical framework - New Institutional theory - was adopted to inform this investigation. With the liberalisation of the telecommunications industry at the end of the 1990's, Marconi was pressed to adopt ABC by several of its constituencies, in particular by its managers, the Portuguese telecommunications regulator (ICP), the European Union (EU), its parent company (PT - Portugal Telecom), and the consultants. While coercive, isomorphic management accounting change was imposed by the national and European regulator, and by Marconi's parent company, mimetic pressures were imposed by the consultants. This investigation showed that ABC was adopted by Marconi for a threefold reason: (1) as a means for Marconi to enhance its efficiency in the highly competitive Portuguese and European telecommunications markets; (2) to gain social legitimacy regarding the way costs are calculated and interconnection prices are established, in the eyes of public opinion, the regulator and capital markets; and (3) to prove to its constituencies that it is a 'modern' and efficient operator