Targetry and radiochemistry for no-carrier-added production of 117,118m,119,120m,122Sb

Targetry of natSn-target on Cu substrate was investigated for the production of 117,118m,119,120m,122Sb. The electrodeposition experiments were carried out using potassium stannate trihydrate and potassium hydroxide. The optimum conditions of the electrodeposition of tin were as follows: 40 g/L natSn, temperature 75°C and current density (dc) used throughout of 50 mA/cm2. The deposited target was irradiated at 160 ěA current and 16 MeV proton beam (10 min). Separation of no-carrier-added (nca) 117,118m,119,120m,122Sb from the irradiated natSn target hydrochloric solution was investigated using silica-gel column chromatography

Computer simulation of temperature distribution on a solid target for 201Tl production

Thallium-201 is of great interest in nuclear medicine for diagnostic purposes. It is produced by the 203Tl(p,3n)201Pb nuclear reaction. Since the target for 201Tl production is a solid target and the maximum beam current for the irradiation has a direct relation with its temperature surface, therefore, the control of temperature during the irradiation is essential. Designing a proper cooling system is one of the important and determining parameters in radionuclide production efficiency. Non-controlled temperature would cause melting and consequently loss of target materials that could be very costly especially when an isotopically enriched material is used. In this study, the heat transfer and temperature distribution on the target has been simulated based on a computational fluid dynamics (CDF) code for the thermal behavior of the target during the irradiation and under the different beam currents, cooling flow rates and target designing. The results on the routinely used target for the production of 201Tl in AMIRS, showed that there was a good linearity between proton beam currents (in the range of 100–350 mi A) and maximum temperature on the thallium target (345–458 K). The results also showed that the flow rate of the cooling water can be brought down (from routinely used 45 L/min) to 15 L/min without any risk of melting of target material

Therapeutic Radiopharmaceuticals Labelled with Copper-67, Rhenium-186 and Scandium-47 (IAEA-TECDOC-1945)

Theranostic radiopharmaceuticals have shown tremendous capabilities in the last decade in the treatment and diagnosis of human diseases via nuclear medicine procedures. In particular, the use of radiometals has experienced a great increase as a result of the development of relevant production technologies. This publication presents the outcome of an IAEA coordinated research project (CRP) focusing on the production, quality control and radiopharmaceutical aspects of three key radionuclides, 67CU, 186Re and 47Sc, which have been selected based on their theranostic potential and their dual production routes. The publication was compiled using inputs from experts in the field as well as presenting the overall results of the CRP. It contains separate sections for each radionuclide including: nuclear data and information on targetry, irradiation, chemical separation, quality control as well as sample radiopharmaceutical production. The findings and considerations will be of use to scientists and technologists interested in translating research reactor and cyclotron based radioisotope production into practice, as well as to post graduate students in the field