Kagera Regional and District Projections

This report presents population projections for the period 2003 to 2025 for the Kagera Region and its districts. The projections were made using a Cohort Component Method (Spectrum System), whereby three components responsible for population change, namely: mortality, fertility and migration were projected separately as well as HIV/AIDS prevalence. The projected components were then applied to 2002 midyear base population in order to come up with the desired projections from 2003 to 2025. The report gives mortality, fertility, migration and HIV/AIDS assumptions, which depicts Kagera’s demographic and socio-economic future trends. The results include estimated population by sex in single years and five-year age groups as well as some demographic indicators. Population growth for the period 2003 to 2025 shows an increase in growth rates. The projections show that population growth rate will increase from 3.1 percent in 2003 (with a population of 1,982,612) to 3.7 percent in 2025 (with a population of 4,511,927). Sex Ratio at birth is projected to increase from 96 male births per 100 females in 2003 to 99 male births per 100 females in 2025. Mortality estimates show that Infant Mortality Rate (IMR) is expected to decline for both sexes from 117 deaths per 1,000 live births in 2003 to 72 deaths per 1,000 live births in 2025. Under Five Mortality Rate (U5MR) for both sexes will also decline from 195 deaths per 1,000 live births in 2003 to 113 deaths per 1,000 live births in the year 2025. The mortality projected estimates further show that the life expectancy at birth for females is higher compared to that of males, which is expected. Life expectancy at birth for Kagera will increase from 48 years in 2003 to 55 years in 2025 for both sexes. For male population, life expectancy at birth will increase from 46 years in year 2003 to 54 years in 2025, while for female population the life expectancy at birth will increase from 49 years in 2003 to 56 years in 2025

Manyara Regional and District Projections

This report presents population projections for the period 2003 to 2025 for the Manyara Region and its districts. The projections were made using the Cohort Component Method (Spectrum System), whereby three components responsible for population change, namely: mortality, fertility and migration are projected separately as well as HIV/AIDS prevalence. The projected components are then applied to 2002 midyear base population in order to come up with the desired projections from 2003 to 2025. The report gives mortality, fertility, migration and HIV/AIDS assumptions, which depicts Manyara’s demographic and socio-economic future trends. The results include estimated population by sex in single years and five-year age groups as well as some demographic indicators. Population growth for the period 2003 to 2025 shows an increase in growth rates. The projections show that population growth rate will increase from 3.9 percent in 2003 (with a population of 1,075,022) to 4.2 percent in 2025 (with a population of 2,483,873). Sex Ratio at birth is projected to decrease from 105 male births per 100 females in 2003 to 103 male births per 100 females in 2025. Mortality estimates show that Infant Mortality Rate (IMR) is expected to decline for both sexes from 62 deaths per 1,000 live births in 2003 to 31 deaths per 1,000 live births in 2025. Under Five Mortality Rate (U5MR) for both sexes will also decline from 96 deaths per 1,000 live births in 2003 to 42 deaths per 1,000 live births in the year 2025. The mortality projected estimates further show that the life expectancy at birth for females is higher compared to that of males, which is expected. Life expectancy at birth for Manyara will increase from 61 years in 2003 to 68 years in 2025 for both sexes. For male population, life expectancy at birth will increase from 60 years in year 2003 to 66 years in 2025, while for female population the life expectancy at birth will increase from 62 years in 2003 to 69 years in 2025. On fertility, TFR will increase from 6.4 children per woman in 2003 to 6.8 children per woman in 2025

Lindi Regional and District Projections

\ud This report presents population projections for the period 2003 to 2025 for Lindi Region and its districts. The projections were made using a Cohort Component Method (Spectrum System), whereby three components responsible for population change, namely: mortality, fertility and migration were projected separately as well as HIV/AIDS prevalence. The projected components were then applied to 2002 midyear base population in order to come up with the desired projections from 2003 to 2025. The report gives mortality, fertility, migration and HIV/AIDS assumptions, and shows Lindi’s demographic and socio-economic future trends. The results include estimated population by sex in single years and five-year age groups as well as some demographic indicators. Population growth for the period 2003 to 2025 shows fluctuations. The projections show that\ud population growth rate will increase from 1.4 percent in 2003 (with a population of 801,189) to 1.6 percent in 2025 (with a population of 1,209,623). Sex Ratio at birth is projected to increase from 93 males births per 100 females in 2003 to 97 males births per 100 females in 2025. Mortality estimates show that Infant Mortality Rate (IMR) is expected to decline for both sexes from 116 deaths per 1,000 live births in 2003 to 53 deaths per 1,000 live births in 2025. Under Five Mortality Rate (U5MR) for both sexes will also decline from 194 deaths per 1,000 live births in 2003 to 80 deaths per 1,000 live births in the year 2025. The mortality projected estimates further show that the life expectancy at birth for females is higher compared to that of males. Life expectancy at birth for Lindi will increase from 48 years in 2003 to 60 years in 2025 for both sexes. For male population, life expectancy at birth will increase from 47 years in year 2003 to 59 years in 2025, while for female population the life expectancy at birth will increase from 49 years in 2003 to 61 years in 2025. On fertility, TFR will decline from 4.4 children per woman in 2003 to 3.4 children per woman in 2025.\u

Singida Regional and District Projections

\ud This report presents population projections for the period 2003 to 2025 for Singida Region and its districts. The projections were made using a Cohort Component Method (Spectrum System), whereby three components responsible for population change, namely: mortality, fertility and\ud migration were projected separately as well as HIV/AIDS prevalence. The projected components were then applied to 2002 midyear base population in order to come up with the desired projections from 2003 to 2025. The report gives mortality, fertility, migration and HIV/AIDS assumptions, and shows Singida’s demographic and socio-economic future trends. The results include estimated population by sex in single years and five-year age groups as well as some demographic indicators. The results show that population growth for the period 2003 to 2025 shows a decrease in growth rates. The projections show that population growth rate will decrease from 2.4 percent in 2003 (with a population of 1,118,874) to 1.5 percent in 2025 (with a population of 1,897,726). Sex Ratio at birth is projected to increase from 95 males per 100 females in 2003 to 100 males per 100 females in 2025. Mortality estimates show that Infant Mortality Rate (IMR) is expected to decline for both sexes from 84 deaths per 1,000 live births in 2003 to 43 deaths per 1,000 live births in 2025. Under Five Mortality Rate (U5MR) for both sexes will also decline from 135 deaths per 1,000 live births in 2003 to 62 deaths per 1,000 live births in the year 2025. The mortality projected estimates further show that the life expectancy at birth for females is higher compared to that of males as expected. Life expectancy at birth for Singida will increase from 55 years in 2003 to 63 years in 2025 for both sexes. For male population, life expectancy at birth will increase from 56 years in year 2003 to 63 years in 2025, while for female population, the life expectancy at birth will increase from 54 years in 2003 to 63 years in 2025. On fertility, TFR will decline from 6.0 children per woman in 2003 to 3.0 children per woman in 2025.\u

Kilimanjaro Regional and District Projections

\ud This report presents population projections for the period 2003 to 2025 for Kilimanjaro Region and its districts. The projections were made using a Cohort Component Method (Spectrum System), whereby three components responsible for population change, namely: mortality, fertility and migration were projected separately as well as HIV/AIDS prevalence. The projected components were then applied to 2002 midyear base population in order to come up with the desired projections from 2003 to 2025. The report gives mortality, fertility, migration and HIV/AIDS assumptions, and shows Kilimanjaro’s demographic and socio-economic future trends. The results include estimated population by sex in single years and five-year age groups as well as some demographic indicators. Population growth for the period 2003 to 2025 shows a decrease in growth rates. The projections show that population growth rate will decrease from 1.7 percent in 2003 (with a population of 1,406,470) to 1.0 percent in 2025 (with a population of 2,083,220). Sex Ratio at birth is projected to increase from 94 male births per 100 females in 2003 to 98 male births per 100 females in 2025. Mortality estimates show that Infant Mortality Rate (IMR) is expected to decline for both sexes from 44 deaths per 1,000 live births in 2003 to 12 deaths per 1,000 live births in 2025. Under Five Mortality Rate (U5MR) for both sexes will also decline from 61 deaths per 1,000 live births in 2003 to 15 deaths per 1,000 live births in the year 2025. The mortality projected estimates further show that the life expectancy at birth for males is lower compared to that of females in 2003 and remains almost the same in 2025. Life expectancy at birth for Kilimanjaro will increase from 65 years in 2003 to 67 years in 2025 for both sexes. For male population, life expectancy at birth will increase from 64 years in year 2003 to 67 years in 2025, while for female population, the life expectancy at birth will remain the same at 67 in both 2003 and 2025. On fertility, TFR will decline from 4.1 children per woman in 2003 to 2.2 children per woman in 2025.\u

G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an autosomal recessive form of this disorder to chromosome 13q14.11-13q21.33, and identified homozygous truncating mutations in P2RY5, which encodes an orphan G protein-coupled receptor. Furthermore, we identified oleoyl-L-alpha-lysophosphatidic acid (LPA), a bioactive lipid, as a ligand for P2Y5 in reporter gene and radioligand binding experiments. Homology and studies of signaling transduction pathways suggest that P2Y5 is a member of a subgroup of LPA receptors, which also includes LPA4 and LPA5. Our study is the first to implicate a G protein-coupled receptor as essential for and specific to the maintenance of human hair growth. This finding may provide opportunities for new therapeutic approaches to the treatment of hair loss in humans