Rethinking CMB foregrounds: systematic extension of foreground parameterizations

Future high-sensitivity measurements of the cosmic microwave background (CMB) anisotropies and energy spectrum will be limited by our understanding and modeling of foregrounds. Not only does more information need to be gathered and combined, but also novel approaches for the modeling of foregrounds, commensurate with the vast improvements in sensitivity, have to be explored. Here, we study the inevitable effects of spatial averaging on the spectral shapes of typical foreground components, introducing a moment approach, which naturally extends the list of foreground parameters that have to be determined through measurements or constrained by theoretical models. Foregrounds are thought of as a superposition of individual emitting volume elements along the line of sight and across the sky, which then are observed through an instrumental beam. The beam and line of sight averages are inevitable. Instead of assuming a specific model for the distributions of physical parameters, our method identifies natural new spectral shapes for each foreground component that can be used to extract parameter moments (e.g., mean, dispersion, cross-terms, etc.). The method is illustrated for the superposition of power-laws, free-free spectra, gray-body and modified blackbody spectra, but can be applied to more complicated fundamental spectral energy distributions. Here, we focus on intensity signals but the method can be extended to the case of polarized emission. The averaging process automatically produces scale-dependent spectral shapes and the moment method can be used to propagate the required information across scales in power spectrum estimates. The approach is not limited to applications to CMB foregrounds but could also be useful for the modeling of X-ray emission in clusters of galaxies.Comment: 19 pages, 8 figures, accepted by MNRAS, minor revision

Prospects for Measuring Cosmic Microwave Background Spectral Distortions in the Presence of Foregrounds

Measurements of cosmic microwave background spectral distortions have profound implications for our understanding of physical processes taking place over a vast window in cosmological history. Foreground contamination is unavoidable in such measurements and detailed signal-foreground separation will be necessary to extract cosmological science. We present MCMC-based spectral distortion detection forecasts in the presence of Galactic and extragalactic foregrounds for a range of possible experimental configurations, focusing on the Primordial Inflation Explorer (PIXIE) as a fiducial concept. We consider modifications to the baseline PIXIE mission (operating 12 months in distortion mode), searching for optimal configurations using a Fisher approach. Using only spectral information, we forecast an extended PIXIE mission to detect the expected average non-relativistic and relativistic thermal Sunyaev-Zeldovich distortions at high significance (194$\sigma$ and 11$\sigma$, respectively), even in the presence of foregrounds. The $\Lambda$CDM Silk damping $\mu$-type distortion is not detected without additional modifications of the instrument or external data. Galactic synchrotron radiation is the most problematic source of contamination in this respect, an issue that could be mitigated by combining PIXIE data with future ground-based observations at low frequencies ($\nu < 15-30$GHz). Assuming moderate external information on the synchrotron spectrum, we project an upper limit of $|\mu| < 3.6\times 10^{-7}$ (95\% c.l.), slightly more than one order of magnitude above the fiducial $\Lambda$CDM signal from the damping of small-scale primordial fluctuations, but a factor of $\simeq 250$ improvement over the current upper limit from COBE/FIRAS. This limit could be further reduced to $|\mu| < 9.4\times 10^{-8}$ (95\% c.l.) with more optimistic assumptions about low-frequency information. (Abridged)Comment: (16 pages, 11 figures, submitted to MNRAS. Fisher code available at https://github.com/mabitbol/sd_foregrounds. Updated with published version.

Measuring the Hubble constant from the cooling of the CMB monopole

The cosmic microwave background (CMB) monopole temperature evolves with the inverse of the cosmological scale factor, independent of many cosmological assumptions. With sufficient sensitivity, real-time cosmological observations could thus be used to measure the local expansion rate of the Universe using the cooling of the CMB. We forecast how well a CMB spectrometer could determine the Hubble constant via this method. The primary challenge of such a mission lies in the separation of Galactic and extra-Galactic foreground signals from the CMB at extremely high precision. However, overcoming these obstacles could potentially provide an independent, highly robust method to shed light on the current low-/high-$z$ Hubble tension. An experiment with 3000 linearly spaced bins between 5 GHz and 3 THz with a sensitivity of 1 $\mathrm{mJy\sqrt{yr}~sr^{-1}}$ per bin, could measure $H_0$ to 3% over a 10 year mission, given current foreground complexity. This sensitivity would also enable high-precision measurements of the expected $\Lambda$CDM spectral distortions, but remains futuristic at this stage.Comment: Authors' accepted version uploaded. (Published in ApJ

Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss

Given the importance of connexin43 (Cx43, encoded by GJA1) function in the central nervous system and sensory organ processing, we proposed that it would also be crucial in auditory function. To that end, hearing was examined in two mouse models of oculodentodigital dysplasia that globally express GJA1 mutations resulting in mild or severe loss of Cx43 function. Although Cx43(I130T/+) mutant mice, with similar to 50% Cx43 channel function, did not have any hearing loss, Cx43(G60S/+) mutant mice, with similar to 20% Cx43 channel function, had severe hearing loss. There was no evidence of inner ear sensory hair cell loss, suggesting that the mechanism for Cx43-linked hearing loss lies downstream in the auditory pathway. Since evidence suggests that Cx26 function is essential for hearing and may be protective against noise-induced hearing loss, we challenged Cx43(I130T/+) mice with a loud noise and found that they had a similar susceptibility to noise-induced hearing loss to that found in controls, suggesting that decreased Cx43 function does not sensitize the mice for environmentally induced hearing loss. Taken together, this study suggests that Cx43 plays an important role in baseline hearing and is essential for auditory processing. This article has an associated First Person interview with the first author of the paper

The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss

Mutations in the genes that encode the gap junction proteins connexin 26 (Cx26, encoded by GJB2) and Cx30 (GJB6) are the leading cause of hereditary hearing loss. That said, the Cx30 p.Ala88Val (A88V) mutant causes Clouston syndrome, but not hearing loss. Here, we report that the Cx30-A88V mutant, despite being toxic to inner ear-derived HEI-OC1 cells, conferred remarkable long-term protection against age-related high frequency hearing loss in Cx30(A88V/A88V) mice. During early development, there were no overt structural differences in the cochlea between genotypes, including a normal complement of hair cells; however, the supporting cell Cx30 gap junction plaques in mutant mice were reduced in size. In adulthood, Cx30(A88V/A88V) mutant mice had a reduction of cochlear Cx30 mRNA and protein, yet a full complement of hair cells. Conversely, the age-related high frequency hearing loss in Cx30(+/+) and Cx30(+/A88V) mice was due to extensive loss of outer hair cells. Our data suggest that the Cx30-A88V mutant confers long-term hearing protection and prevention of hair cell death, possibly via a feedback mechanism that leads to the reduction of total Cx30 gap junction expression in the cochlea

GABAA receptors can initiate the formation of functional inhibitory GABAergic synapses.

The mechanisms that underlie the selection of an inhibitory GABAergic axon's postsynaptic targets and the formation of the first contacts are currently unknown. To determine whether expression of GABAA receptors (GABAA Rs) themselves - the essential functional postsynaptic components of GABAergic synapses - can be sufficient to initiate formation of synaptic contacts, a novel co-culture system was devised. In this system, the presynaptic GABAergic axons originated from embryonic rat basal ganglia medium spiny neurones, whereas their most prevalent postsynaptic targets, i.e. α1/β2/γ2-GABAA Rs, were expressed constitutively in a stably transfected human embryonic kidney 293 (HEK293) cell line. The first synapse-like contacts in these co-cultures were detected by colocalization of presynaptic and postsynaptic markers within 2 h. The number of contacts reached a plateau at 24 h. These contacts were stable, as assessed by live cell imaging; they were active, as determined by uptake of a fluorescently labelled synaptotagmin vesicle-luminal domain-specific antibody; and they supported spontaneous and action potential-driven postsynaptic GABAergic currents. Ultrastructural analysis confirmed the presence of characteristics typical of active synapses. Synapse formation was not observed with control or N-methyl-d-aspartate receptor-expressing HEK293 cells. A prominent increase in synapse formation and strength was observed when neuroligin-2 was co-expressed with GABAA Rs, suggesting a cooperative relationship between these proteins. Thus, in addition to fulfilling an essential functional role, postsynaptic GABAA Rs can promote the adhesion of inhibitory axons and the development of functional synapses

Double deletion of Panx1 and Panx3 affects skin and bone but not hearing

Pannexins (Panxs), large-pore channel forming glycoproteins, are expressed in a wide variety of tissues including the skin, bone, and cochlea. To date, the use of single knock-out mouse models of both Panx1 and Panx3 have demonstrated their roles in skin development, bone formation, and auditory phenotypes. Due to sequence homology between Panx1 and Panx3, when one Panx is ablated from germline, the other may be upregulated in a compensatory mechanism to maintain tissue homeostasis and function. To evaluate the roles of Panx1 and Panx3 in the skin, bone, and cochlea, we created the first Panx1/Panx3 double knock-out mouse model (dKO). These mice had smaller litters and reduced body weight compared to wildtype controls. The dKO dorsal skin had decreased epidermal and dermal area as well as decreased hypodermal area in neonatal but not in older mice. In addition, mouse skull shape and size were altered, and long bone length was decreased in neonatal dKO mice. Finally, auditory tests revealed that dKO mice did not exhibit hearing loss and were even slightly protected against noise-induced hearing damage at mid-frequency regions. Taken together, our findings suggest that Panx1 and Panx3 are important at early stages of development in the skin and bone but may be redundant in the auditory system. Key messages Panx double KO mice had smaller litters and reduced body weight. dKO skin had decreased epidermal and dermal area in neonatal mice. Skull shape and size changed plus long bone length decreased in neonatal dKO mice. dKO had no hearing loss and were slightly protected against noise-induced damage