Resilience in Caregivers of Partners With Young Onset Dementia: A Concept Analysis

Introduction: Over 200,000 Americans diagnosed with young onset dementia (YOD), dementia diagnosed prior to age 65, are cared for by family members. This can be costly to caregivers’physical and psychological health. Some adapt well to the caregiver role and are said to be resilient. Aim/Question: This paper builds on current understanding of the concept of resilience and applies this to caregivers of partners diagnosed with YOD. Method: Concept analysis. Results: Resilient caregivers exhibit attributes including determination, flexibility, positive thinking, self-efficacy, resourcefulness, social support and spirituality. Discussion: YOD affects caregiver’s health. Much research has been done on interventions for dementia caregivers. These interventions do not necessarily meet the needs of YOD caregivers as they do not account for dynamics in the family. By recognizing what is resiliency in YOD caregivers, interventions can be developed that focus on characteristics that build these attributes. Implications for Practice: Understanding the concept of resilience related to caregiving for a partner diagnosed with YOD allows for future development, measurement, and evaluation of nursing interventions. Nursing staff are in a strategic position to provide effective interventions to enhance resilience among caregivers of YOD

Colour-singlet clustering of partons and recombination model for hadronization of quark-gluon plasma

$SU(N_c)$ colour-singlet restriction, along with flavour and spin symmetry, on thermal partonic ensemble is shown to recombine the partons with internal colour structure into colour-singlet multi-quark clusters which can be identified with various hadronic modes at a given temperature. This provides a possible basis for recombination model for hadronization of quark-gluon plasma. This also leads to a natural explanation for the ratio of (anti)protons to pions and the quark number scaling of the elliptic flow coefficient in relativistic heavy-ion collisions.Comment: 5 pages; version accepted as a Rapid Communication in Phys. Rev.

Polylithiated (OLi2) functionalized graphane as a potential hydrogen storage material

Hydrogen storage capacity, stability, bonding mechanism and the electronic structure of polylithiated molecules (OLi2) functionalized graphane (CH) has been studied by means of first principle density functional theory (DFT). Molecular dynamics (MD) have confirmed the stability, while Bader charge analysis describe the bonding mechanism of OLi2 with CH. The binding energy of OLi2 on CH sheet has been found to be large enough to ensure its uniform distribution without any clustering. It has been found that each OLi2 unit can adsorb up to six H2 molecules resulting into a storage capacity of 12.90 wt% with adsorption energies within the range of practical H2 storage application.Comment: 11 pages, 4 figures, 1 table, Phys. Chem. Chem. Phys. (submitted

Strain induced lithium functionalized graphane as a high capacity hydrogen storage material

Strain effects on the stability, electronic structure, and hydrogen storage capacity of lithium-doped graphane (CHLi) have been investigated by stateof-the art first principle density functional theory (DFT). Molecular dynamics MD) simulations have confirmed the stability of Li on graphane sheet when it is subject to 10% of tensile strain. Under biaxial asymmetric strain, the binding energy of Li of graphane (CH) sheet increases by 52% with respect to its bulk's cohesive energy. With 25% doping concentration of Li on CH sheet,the gravimetric density of hydrogen storage is found to reach up to 12.12wt%. The adsorption energies of H2 are found to be within the range of practical H2 storage applications.Comment: 13 pages, 7 figures, 1 table, Applied Physics Letters (Under Review

Vasoactive Intestinal Peptide and Its Receptors in Human Ovarian Cortical Follicles

BACKGROUND: Ovarian cryopreservation is one option for fertility preservation in patients with cancer. The danger of reseeding malignancies could be eliminated by in vitro maturation of primordial follicles from the frozen-thawed tissue. However, the development of this system is hindered by uncertainties regarding factors that activate primordial follicles. Neuronal growth factors such as vasoactive intestinal peptide (VIP) play important roles in early mammalian folliculogenesis. There are no data on the expression of VIP and its vasoactive intestinal peptide pituitary adenylate cyclase 1 and 2 receptors (VPAC1-R and VPAC2-R) in human preantral follicles. METHODOLOGY/PRINCIPAL FINDINGS: Tissue samples from 14 human fetal ovaries and 40 ovaries from girls/women were prepared to test for the expression of VIP, VPAC1-R, and VPAC2-R on the protein (immunohistochemisty) and mRNA (reverse transcription polymerase chain reaction) levels. Immunohistochemistry staining was mostly weak, especially in fetal samples. The VIP protein was identified in oocytes and granulosa cells (GCs) in the fetal samples from 22 gestational weeks (GW) onwards. In girls/women, VIP follicular staining (oocytes and GCs) was identified in 45% of samples. VPAC1-R protein was identified in follicles in all fetal samples from 22GW onwards and in 63% of the samples from girls/women (GC staining only in 40%). VPAC2-R protein was identified in follicles in 33% of fetal samples and 47% of the samples from girls/women. The mRNA transcripts for VIP, VPAC1-R, and VPAC2-R were identified in ovarian extracts from fetuses and women. CONCLUSIONS: VIP and its two receptors are expressed in human ovarian preantral follicles. However, their weak staining suggests they have limited roles in early follicular growth. To elucidate if VIP activates human primordial follicles, it should be added to the culture medium

Facile and reversible double dearomatization of pyridines in non-phosphine MnI complexes with N,S-donor pyridinophane ligand

Single and double dearomatization of pyridine rings was observed in Mn(I) complexes with an N2S2 pyridinophane ligand via deprotonation of one or two CH2 arms, respectively. In contrast to other N,S-donor pincer-like systems, the dearomatized (N2S2)Mn species were found to be stable, with the dearomatization being reversible

Empirical determination of charm quark energy loss and its consequences for azimuthal anisotropy

We propose an empirical model to determine the form of energy loss of charm quarks due to multiple scatterings in quark gluon plasma by demanding a good description of production of D mesons and non-photonic electrons in relativistic collision of heavy nuclei at RHIC and LHC energies. Best results are obtained when we approximate the momentum loss per collision $\Delta p_T \propto \alpha \, p_T$, where $\alpha$ is a constant depending on the centrality and the centre of mass energy. Comparing our results with those obtained earlier for drag coefficients estimated using Langevin equation for heavy quarks we find that up to half of the energy loss of charm quarks at top RHIC energy could be due to collisions while that at LHC energy at 2760 GeV/A the collisional energy loss could be about one third of the total. Estimates are obtained for azimuthal anisotropy in momentum spectra of heavy mesons, due to this energy loss. We further suggest that energy loss of charm quarks may lead to an enhanced production of D-mesons and single electrons at low $p_T$ in AA collisions.Comment: 11 pages, 3 figures, Typographical errors corrected, Key-words and PACS indices added, sequence of figures corrected, references added in section 3, discussions expande