Pentagastric infusions in patients with panic disorder I. Symptoms and cardiovascular responses

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142733/1/Abelson-Nesse-Penta_Infusions-BioPsych-1994.pd

The effects of central cholecystokinin receptor blockade on hypothalamic-pituitary-adrenal and symptomatic responses to overnight withdrawal from alprazolam

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142739/1/Abelson-Nesse-alprazolam-BioPsych-1995.pd

Respiratory Psychophysiology and Anxiety: Cognitive Intervention in the Doxapram Model of Panic

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142769/1/Nesse-Abelson-Psychophysiology-PsychMed-1996.pd

Brain Mechanisms of Social Threat Effects on Working Memory

Social threat can have adverse effects on cognitive performance, but the brain mechanisms underlying its effects are poorly understood. We investigated the effects of social evaluative threat on working memory (WM), a core component of many important cognitive capabilities. Social threat impaired WM performance during an N-back task and produced widespread reductions in activation in lateral prefrontal cortex and intraparietal sulcus (IPS), among other regions. In addition, activity in frontal and parietal regions predicted WM performance, and mediation analyses identified regions in the bilateral IPS that mediated the performance-impairing effects of social threat. Social threat also decreased connectivity between the IPS and dorsolateral prefrontal cortex, while increasing connectivity between the IPS and the ventromedial prefrontal cortex, a region strongly implicated in the generation of autonomic and emotional responses. Finally, cortisol response to the stressor did not mediate WM impairment but was rather associated with protective effects. These results provide a basis for understanding interactions between social and cognitive processes at a neural systems level