Cosmological parameters from Galaxy Clusters: an Introduction

This lecture is an introduction to cosmological tests with clusters of galaxies. Here I do not intend to provide a complete review of the subject, but rather to describe the basic procedures to set up the fitting machinery to constrain cosmological parameters from clusters, and to show how to handle data with a critical insight. I will focus mainly on the properties of X-ray clusters of galaxies, showing their success as cosmological tools, to end up discussing the complex thermodynamics of the diffuse intracluster medium and its impact on the cosmological tests.Comment: 32 pages, 16 figures, conference proceedings for the 3rd Aegean Summer School, Chios, 26 September - 1 October, 200

Diabetic gastroparesis: Therapeutic options

Gastroparesis is a condition characterized by delayed gastric emptying and the most common known underlying cause is diabetes mellitus. Symptoms include nausea, vomiting, abdominal fullness, and early satiety, which impact to varying degrees on the patient’s quality of life. Symptoms and deficits do not necessarily relate to each other, hence despite significant abnormalities in gastric emptying, some individuals have only minimal symptoms and, conversely, severe symptoms do not always relate to measures of gastric emptying. Prokinetic agents such as metoclopramide, domperidone, and erythromycin enhance gastric motility and have remained the mainstay of treatment for several decades, despite unwanted side effects and numerous drug interactions. Mechanical therapies such as endoscopic pyloric botulinum toxin injection, gastric electrical stimulation, and gastrostomy or jejunostomy are used in intractable diabetic gastroparesis (DG), refractory to prokinetic therapies. Mitemcinal and TZP-101 are novel investigational motilin receptor and ghrelin agonists, respectively, and show promise in the treatment of DG. The aim of this review is to provide an update on prokinetic and mechanical therapies in the treatment of DG

A model of the informal structure (culture) of organizations: help, trust, rivalry and team spirit

Corporate culture is conceived of as a mixture of intra-organizational mechanisms which balance cooperative (helping) and competitive (rivalrous) relationships. A simple game whereby individuals compete for a series of `prizes' induces a level of relative deprivation which impacts negatively upon a helping game. Individuals, however, need help from others to compete effectively for the prizes