TeV scale resonant leptogenesis from supersymmetry breaking

We propose a model of TeV-scale resonant leptogenesis based upon recent models of the generation of light neutrino masses from supersymmetry-breaking effects with TeV-scale right-handed (rhd) neutrinos, $N_i$. The model leads to naturally large cosmological lepton asymmetries via the resonant behaviour of the one-loop self-energy contribution to $N_i$ decay. Our model addresses the primary problems of previous phenomenological studies of low-energy leptogenesis: a rational for TeV-scale rhd neutrinos with small Yukawa couplings so that the out-of equilibrium condition for $N_i$ decay is satisfied; the origin of the tiny, but non-zero mass splitting required between at least two $N_i$ masses; and the necessary non-trivial breaking of flavour symmetries in the rhd neutrino sector. The low mass-scale of the rhd neutrinos and their superpartners, and the TeV-scale $A$-terms automatically contained within the model offer opportunities for partial direct experimental tests of this leptogenesis mechanism at future colliders.Comment: 10 Pages latex, version for JHE

Probing CP Violation with the Deuteron Electric Dipole Moment

We present an analysis of the electric dipole moment (EDM) of the deuteron as induced by CP-violating operators of dimension 4, 5 and 6 including theta QCD, the EDMs and color EDMs of quarks, four-quark interactions and the Weinberg operator. We demonstrate that the precision goal of the EDM Collaboration's proposal to search for the deuteron EDM, (1-3)\times 10^{-27} e cm, will provide an improvement in sensitivity to these sources of one-two orders of magnitude relative to the existing bounds. We consider in detail the level to which CP-odd phases can be probed within the MSSM.Comment: 5 pages, 4 figures; precision estimates clarified, to appear in Phys. Rev.

Spontaneous CP Violation in Non-Minimal Supersymmetric Models

We study the possibilities of spontaneous CP violation in the Next-to-Minimal Supersymmetric Standard Model with an extra singlet tadpole term in the scalar potential. We calculate the Higgs boson masses and couplings with radiative corrections including dominant two loop terms. We show that it is possible to satisfy the LEP constraints on the Higgs boson spectrum with non-trivial spontaneous CP violating phases. We also show that these phases could account for the observed value of epsilonK.Comment: 21 pages, 7 Figures in Encapsulated Postscrip

Genotyping cognate Plasmodium falciparum in humans and mosquitoes to estimate onward transmission of asymptomatic infections

Malaria control may be enhanced by targeting reservoirs of Plasmodium falciparum transmission. One putative reservoir is asymptomatic malaria infections and the scale of their contribution to transmission in natural settings is not known. We assess the contribution of asymptomatic malaria to onward transmission using a 14-month longitudinal cohort of 239 participants in a high transmission site in Western Kenya. We identify P. falciparum in asymptomatically- and symptomatically-infected participants and naturally-fed mosquitoes from their households, genotype all parasites using deep sequencing of the parasite genes pfama1 and pfcsp, and use haplotypes to infer participant-to-mosquito transmission through a probabilistic model. In 1,242 infections (1,039 in people and 203 in mosquitoes), we observe 229 (pfcsp) and 348 (pfama1) unique parasite haplotypes. Using these to link human and mosquito infections, compared with symptomatic infections, asymptomatic infections more than double the odds of transmission to a mosquito among people with both infection types (Odds Ratio: 2.56; 95% Confidence Interval (CI): 1.36–4.81) and among all participants (OR 2.66; 95% CI: 2.05–3.47). Overall, 94.6% (95% CI: 93.1–95.8%) of mosquito infections likely resulted from asymptomatic infections. In high transmission areas, asymptomatic infections are the major contributor to mosquito infections and may be targeted as a component of transmission reduction

Impact of asymptomatic plasmodium falciparum infection on the risk of subsequent matic malaria in a longitudinal cohort in Kenya

Background: Asymptomatic Plasmodium falciparum infections are common in sub-Saharan Africa, but their effect on subsequent symptomaticity is incompletely understood. Methods: In a 29-month cohort of 268 people in Western Kenya, we investigated the association between asymptomatic P. falciparum and subsequent symptomatic malaria with frailty Cox models. Results: Compared to being uninfected, asymptomatic infections were associated with an increased 1-month likelihood of symptomatic malaria [adjusted Hazard Ratio (aHR):2.61, 95%CI:2.05–3.33], and this association was modified by sex, with females [aHR:3.71, 95%CI:2.62–5.24] at higher risk for symptomaticity than males [aHR:1.76, 95%CI:1.24–2.50]. This increased symptomatic malaria risk was observed for asymptomatic infections of all densities and in people of all ages. Long-term risk was attenuated but still present in children under 5 [29-month aHR:1.38, 95%CI:1.05–1.81]. Conclusions: In this high-transmission setting, asymptomatic P. falciparum can be quickly followed by symptoms and may be targeted to reduce the incidence of symptomatic illness

Time-Space Noncommutativity in Gravitational Quantum Well scenario

A novel approach to the analysis of the gravitational well problem from a second quantised description has been discussed. The second quantised formalism enables us to study the effect of time space noncommutativity in the gravitational well scenario which is hitherto unavailable in the literature. The corresponding first quantized theory reveals a leading order perturbation term of noncommutative origin. Latest experimental findings are used to estimate an upper bound on the time--space noncommutative parameter. Our results are found to be consistent with the order of magnitude estimations of other NC parameters reported earlier.Comment: 7 pages, revTe

Fermion Electric Dipole Moments in Supersymmetric Models with R-parity Violation

We analyze the electron and neutron electric dipole moments induced by R-parity violating interactions in supersymmetric models. It is pointed out that dominant contributions can come from one-loop diagrams involving both the bilinear and trilinear R-parity odd couplings, leading to somewhat severe constraints on the products of those couplings.Comment: Revtex, 19pp, four figures in axodraw.st

Exposure to Diverse Plasmodium falciparum Genotypes Shapes the Risk of Symptomatic Malaria in Incident and Persistent Infections: A Longitudinal Molecular Epidemiologic Study in Kenya

Background: Repeated exposure to malaria infections could protect against symptomatic progression as people develop adaptive immunity to infections acquired over time. Methods: We investigated how new, recurrent, and persistent Plasmodium falciparum infections were associated with the odds of developing symptomatic compared with asymptomatic malaria. Using a 14-month longitudinal cohort in Western Kenya, we used amplicon deep sequencing of 2 polymorphic genes (pfama1 and pfcsp) to assess overlap of parasite genotypes (represented by haplotypes) acquired within an individual's successive infections. We hypothesized infections with novel haplotypes would increase the odds of symptomatic malaria. Results: After excluding initial infections, we observed 534 asymptomatic and 88 symptomatic infections across 186 people. We detected 109 pfcsp haplotypes, and each infection was classified as harboring novel, recurrent, or persistent haplotypes. Incident infections with only new haplotypes had higher odds of symptomatic malaria when compared with infections with only recurrent haplotypes [odds ratio (OR): 3.24; 95% confidence interval (CI), 1.20-8.78], but infections with both new and recurrent haplotypes (OR: 0.64; 95% CI: 0.15-2.65) did not. Assessing persistent infections, those with mixed (persistent with new or recurrent) haplotypes (OR: 0.77; 95% CI: 0.21-2.75) had no association with symptomatic malaria compared with infections with only persistent haplotypes. Results were similar for pfama1. Conclusions: These results confirm that incident infections with only novel haplotypes were associated with increased odds of symptomatic malaria compared with infections with only recurrent haplotypes but this relationship was not seen when haplotypes persisted over time in consecutive infections

Constrained Supersymmetric Flipped SU(5) GUT Phenomenology

We explore the phenomenology of the minimal supersymmetric flipped SU(5) GUT model (CFSU(5)), whose soft supersymmetry-breaking (SSB) mass parameters are constrained to be universal at some input scale, $M_{in}$, above the GUT scale, $M_{GUT}$. We analyze the parameter space of CFSU(5) assuming that the lightest supersymmetric particle (LSP) provides the cosmological cold dark matter, paying careful attention to the matching of parameters at the GUT scale. We first display some specific examples of the evolutions of the SSB parameters that exhibit some generic features. Specifically, we note that the relationship between the masses of the lightest neutralino and the lighter stau is sensitive to $M_{in}$, as is the relationship between the neutralino mass and the masses of the heavier Higgs bosons. For these reasons, prominent features in generic $(m_{1/2}, m_0)$ planes such as coannihilation strips and rapid-annihilation funnels are also sensitive to $M_{in}$, as we illustrate for several cases with tan(beta)=10 and 55. However, these features do not necessarily disappear at large $M_{in}$, unlike the case in the minimal conventional SU(5) GUT. Our results are relatively insensitive to neutrino masses.Comment: 23 pages, 8 figures; (v2) added explanations and corrected typos, version to appear in EPJ

SU(5) Unified Theories from Intersecting Branes

We discuss the first string theory examples of three generation non-supersymmetric SU(5) and {\em flipped} SU(5) GUTS, which break to the Standard model at low energy, without extra matter and/or gauge group factors. Our GUT examples are based on IIA $Z_3$ orientifolds with D6-branes intersecting at non-trivial angles. These theories necessarily satisfy RR tadpoles and are free of NSNS tadpoles as the complex structure moduli are frozen (even though a dilaton tadpole remains) to discrete values. We identify appropriately the bifundamental Higgses responsible for electroweak symmetry breaking. In this way, the neutrino see-saw mechanism get nicely realized in these constructions. Moreover, as baryon number is not a gauged symmetry gauge mediated dimension six operators do contribute to proton decay; however proton lifetime may be safely enhanced by appropriately choosing a high GUT scale. An accompanying natural doublet-triplet splitting guarantees the suppression of scalar mediated proton decay modes and the stability of triplet scalar masses against higher dimensional non-renormalizable operators.Comment: 26 pages, 5 figures; no changes, one comment added in the introductio