The Hilbert-Schmidt Theorem Formulation of the R-Matrix Theory

Using the Hilbert-Schmidt theorem, we reformulate the R-matrix theory in terms of a uniformly and absolutely convergent expansion. Term by term differentiation is possible with this expansion in the neighborhood of the surface. Methods for improving the convergence are discussed when the R-function series is truncated for practical applications.Comment: 16 pages, Late

Deuteron and antideuteron production in Au+Au collisions at sqrt(s_NN)=200 GeV

The production of deuterons and antideuterons in the transverse momentum range 1.1 < p_T < 4.3 GeV/c at mid-rapidity in Au + Au collisions at sqrt(s_NN)=200 GeV has been studied by the PHENIX experiment at RHIC. A coalescence analysis comparing the deuteron and antideuteron spectra with those of protons and antiprotons, has been performed. The coalescence probability is equal for both deuterons and antideuterons and increases as a function of p_T, which is consistent with an expanding collision zone. Comparing (anti)proton yields p_bar/p = 0.73 +/- 0.01, with (anti)deuteron yields: d_bar/d = 0.47 +/- 0.03, we estimate that n_bar/n = 0.64 +/- 0.04.Comment: 326 authors, 6 pages text, 5 figures, 1 Table. Submitted to PRL. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In the present study, we demonstrate a role for MTHFD2 in DNA replication and genomic stability in cancer cells, and perform a drug screen to identify potent and selective nanomolar MTHFD2 inhibitors; protein cocrystal structures demonstrated binding to the active site of MTHFD2 and target engagement. MTHFD2 inhibitors reduced replication fork speed and induced replication stress followed by S-phase arrest and apoptosis of acute myeloid leukemia cells in vitro and in vivo, with a therapeutic window spanning four orders of magnitude compared with nontumorigenic cells. Mechanistically, MTHFD2 inhibitors prevented thymidine production leading to misincorporation of uracil into DNA and replication stress. Overall, these results demonstrate a functional link between MTHFD2-dependent cancer metabolism and replication stress that can be exploited therapeutically with this new class of inhibitors

MATHEMATICAL MODEL OF PECULIARITIES OF SIMILARITY, DIFFERENCES AND GEOGRAPHICAL RELATIONS OF SCOOPS FAUNA OF COASTAL AND ISLAND ECOSYSTEMS OF THE CASPIAN SEA

Aim. The study of the material collected, as well as the construction of mathematical models of specific sadstia and differences of the geographical relations of the fauna scoop coastal and island ecosystems of the North-West.Location. Coastal and island ecosystems.Methods. Traditional methods of collection (light traps, method ofhand collection from the screen) and also collections of the material gathered, arranged by modern systematics are used.Results. Investigations of a lethors who studied scoops during 40 years are generalized but island ecosystems are considered for the first time. Fauna of the Caspian coast and island ecosystems is represented by 902 species. Mathematical model of peculiarities of similarity was constructed on the basis of the data obtained, and it helped to expose geographical relations of scoops fauna of coastal and island ecosystems of the Caspian Sea.Main conclusions. The results obtained together with other insects will be the bans for the composition of fauna cadastre, and will also help to realize the age and origin of islands

Epidemiological features of desease of the female population of Daghestan republic malignant new growths of reproductive system

In clause the condition female of decease of cancer bodies of reproductive system of the population of Republic Dagestan is considered. Dynamics of decease by a cancer of a mammary gland, bodies of a uterus are analyzed, extensive parameters of decease of a cancer these forms of a cancer at women of republic are certain. The age structure of decease is analyzed by malignant new growths of reproductive bodies. Geographical features of distribution of decease by a cancer of bodies of reproductive system at the rural female population of republic are considered

Proton scattering from excited states of atomic hydrogen

© 2018 IOP Publishing Ltd. Wavepacket continuum-discretisation approach is used to calculate excitation, ionization and electron-capture (ec) cross sections for proton collisions with n = 2 states of atomic hydrogen, where n is the principal quantum number. The approach assumes a classical motion for the projectile and is based on the solution of the three-body Schrödinger equation using the two-center expansion of the total scattering wave function. The scattering wave function is expanded in an orthonormal basis set built from negative-energy eigenstates and wavepacket pseudostates representing the continuum of both the target atom and the atom formed by the projectile after capturing the electron. With a sufficiently large basis, due to the strong coupling between channels, the method produces converged cross sections for direct-scattering, ionization and ec processes simultaneously. For the quasi-elastic transitions, where both orbital and magnetic quantum numbers change, the integrated cross section is infinite. Nevertheless, the corresponding transitions probabilities are finite at any given impact parameter, indicating that the angular differential cross sections can be measured. Calculated cross sections for scattering on the metastable 2s state are compared with other theoretical results obtained using atomic-orbital close-coupling and classical-trajectory Monte Carlo approaches. Considerable disagreement with previous calculations has been found for some transitions at various incident energies

Reduced changes in bone mineral density in chronic hepatitis B patients receiving TAF compared with TDF

Oral Presentation 11: Viral Hepatitis B and D - Epidemiology and Natural History 1 - no. OP09