2 research outputs found
Tumoricidal effect of skeletal vibratory signal during Al-Fatihah recitation on human cancer cells
This research attempts to study if physical vibration generated in the human body during recitation of AIFatihah
has an effect on cancer cells. This includes working sequentially on two main objectives. The first
objective is to measure and model skin vibration signals using accelerometer (skin acceleration level) on a
cohort of verified reciters whereby measurement is carried out during recitation. Subsequently the modeled
vibration is simulated on cancer cells (NCI H929: Myeloma) and its growth and viability assessed. At the
time of this final report the first objective was not achieved hence prevented progression to the second
objective. A cohort of 15 reciters has been established but we could not proceed to gauge skin acceleration
level as currently available methods were found to be unreliable. Current methods of mounting accelerometer
to the skin produce highly variable acceleration amplitudes. Various alternatives were devised and attempted,
such as using polystyrene, plastic holders etc failed to fulfil gage repeatability and reproducibility criteria.
Towards the end, preliminary gage study using suction cups as accelerometer mounting adapter showed
promise but the final measurement analysis is yet to be carried out. This research is still ongoing in spite of
the end of study period
Validation of international prognostic index for non-hodgkin's lymphoma in northeast Peninsular Malaysian Malays
Indeks Prognosis Antarabangsa {IPI) telah diketengahkan untuk menstratumkan risiko
pesakit limfoma bukan Hodgkin (NHL) dan mengenalpasti subset pesakit berisiko tinggi
yang mungkin tidak dapat bertindakbalas terhadap kemoterapi dengan memuaskan. IPI
telah dibentuk berlandaskan model populasi pesakit berbangsa barat. Kami telah
menlaksanakan suatu kajian longitudinal melibatkan pesakit NHL aggresif yang
menerima rawatan di Hospital USM dari I haribulan J anuari 1990 ke 31 haribulan
Disember 2000. Kajian ini hanya melibatkan pesakit berbangsa Melayu. Ini bertujuan
untuk menguji kesesuaian penggunaan IPI ke atas etnik tersebut. Ciri-ciri klinikal
sepertimana yang telah diuji dalam model IPI yang asal, telah diuji ke atas kohort kami.
Pencapaian pesakit dari segi kadar respons sempurna (complete response rate : CR),
kadar kemandirian keseluruhan (overall survival rate: OS) dan kadar kemandirian bebas
penyakit (disease free survival rate: DFS) bagi setiap faktor eli atas telah eli olah. Pada
masa yang sama data-data yang diperolehi telah digunakan untuk membentuk profit
penyakit NHL dalam populasi kami.
International prognostic index (IPI) was introduced to risk stratify non-Hodgkin
lymphoma (NHL) patients and to identify high-risk patient who might not respond
favorably to standard chemotherapy. IPI was modeled from a Caucasian based patient
population. We undertook a single center, observational longitudinal study involving all
available patients with aggressive NHL who had received treatment from Hospital USM
between 1st Jan 1990 and 31st Dec 2000. We confined our study to adult Malay patients
to test the applicability of IPI in this racial group. Individual presenting clinical features
was categorized as in the IPI study, and the patients' outcome in terms of complete
response (CR), overall survival (OS) and disease free survival (DFS) rates for each of the
above features were determined. At the same time the available data was used to
characterize NHL disease profile in our patient population