Role of Goldenberry (Fruits with Husk) Extract in Ameliorating the Architecture and Osmotic Fragility of Red Blood Cells in Obese Rats

Goldenberry (GB) is a promising fruit that can be a constituent in many possible nourishments. No notifications were obtained regarding the impact of exposure to goldenberry extract in the viewpoint of blood rheological properties as well as erythrocyte osmotic fragility of red blood cells (RBCs) in obese rats. A substantial reduction in plasma triglyceride, total cholesterol, and LDL, with a considerable increment in HDL levels relative to the obese group (p≤0.05), was observed in rats receiving low and high doses of GB, accompanied by restoration of SOD activity and GSH levels. Rheological parameters of rats' blood have been studied over a wide range of shear rates (225-1875 s-1). A significant decrease in blood viscosity in rats who received low and high doses of GB extract was compatible with every shear rate compared to the control group. The shear stress values of the obese rats reduced appreciably (p≤0.05) in all values of shear rate (from 75 to 500 s-1) proportional to the control group, while in the groups that received low and high doses of GB extract, shear stress was restored to the control values. Finally, administration of GB extract significantly decreased yield stress and indices of whole blood aggregation, with an extremely substantial increment in flow rate, in rats given low or high doses of GB compared to obese ones. The result also showed a decrease in both the average raised osmotic fragility and the hemolysis rate in rats after supplementation with low and high doses of GB extract

Contemporary Trends, Characteristics, and Safety Outcomes Associated With Transcatheter Aortic Valve Replacement in Nonagenarians: Large Database Analysis of 23,507 Patients

Background: Aortic stenosis (AS) is very common in the elderly population. Transcatheter aortic valve replacement (TAVR) has been increasingly used in nonagenarians. However, contemporary data on outcomes are scarce. Methods: The National Readmission Database of the years 2016 to 2019 was queried for nonagenarians who underwent TAVR. December discharges were excluded to allow 30-day follow-up. Logistic and linear regression analysis was used to calculate the temporal trends in categoric and continuous outcomes, respectively. The outcomes evaluated were in-hospital mortality, 30-day readmission, permanent pacemaker implantation, stroke, acute kidney injury (AKI), and length of stay. Results: A total of 23,507 TAVR nonagenarian admissions (50.3% female and 95.9% Medicare insurance) were included in our cohort. Congestive heart failure and hypertension were present in 79% and 89% of patients, respectively. In-hospital mortality and all-cause 30-day readmissions were 2% and 15% and have been stable over years of analysis (P trend = 0.79 and 0.06, respectively). The complications evaluated were permanent pacemaker implantation in-hospital or on readmission (12%), acute kidney injury (12%), stroke in-hospital or on readmission (0.5%), cardiac tamponade (0.2%), and acute limb ischemia (0.2%). The mean length of stay improved from 5.5 days in 2016 to 4.3 days in 2019 (P trend \u3c 0.01). Stroke rates have improved from 1.2% to 0.3% in 2016 and 2019, respectively (P trend \u3c0.01) (Figure 1). [Formula presented] Conclusion: Our analysis showed contemporary trends of TAVR short-term outcomes. The development of new strategies is needed to improve certain outcomes in this age group. Categories: STRUCTURAL: Valvular Disease: Aorti

Contemporary Trends of Racial and Social Disparities in Left Atrial Appendage Closure Procedure: Insights From the National Inpatient Sample

Background: Racial and social disparities in the utilization of cardiovascular interventions, including left atrial appendage occlusion (LAAO), exist in clinical practice. Data on contemporary trends of such disparities are lacking. Methods: The National Inpatient Sample (NIS) for the years 2016 to 2019 was queried for adult admissions above age 65 years with a diagnosis of atrial fibrillation (AF). The primary endpoint was LAAO utilization per income (≤median vs \u3emedian) and race per 100,000 AF admissions and temporal trends of utilization over the years. Logistic regression was utilized to calculate temporal trends. Results: A total of 13.8 million admissions with AF were assessed, of which 53,310 underwent LAAO (mean age 77 ± 6 years; 42% female). LAAO utilization was different between races (405 vs 197 vs 340 per 100,000 AF admissions in White, Black, and Hispanic individuals, respectively; P \u3c 0.001). Admissions with income ≤median had lower LAAO rates than the \u3emedian income group (344 vs 428 per 100,000 AF admissions; P \u3c 0.001). From Q1 2016 to 2019, utilization of LAAO showed an upward trend in all races and income groups (Ptrend \u3c 0.001). However, a significant disparity exists in the utilization of LAAO in the Black population compared with the White population and in the ≤median income group compared with the \u3emedian income group (Figures 1 and 2). [Formula presented] Conclusion: Our contemporary analysis demonstrated the persistence of racial and social disparities in the utilization of LAAO. Further studies are needed to determine the causes of such disparities and develop strategies to ensure access to these procedures for at-risk populations. Categories: STRUCTURAL: Left Atrial Appendage Exclusio

Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry

Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) Non-ST-segment elevation myocardial infarction (NSTEMI) Registry aims to identify international patterns in NSTEMI management in clinical practice and outcomes against the 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without ST-segment-elevation. Methods and results Consecutively hospitalised adult NSTEMI patients (n = 3620) were enrolled between 11 March 2019 and 6 March 2021, and individual patient data prospectively collected at 287 centres in 59 participating countries during a two-week enrolment period per centre. The registry collected data relating to baseline characteristics, major outcomes (inhospital death, acute heart failure, cardiogenic shock, bleeding, stroke/transient ischaemic attack, and 30-day mortality) and guideline-recommended NSTEMI care interventions: electrocardiogram pre- or in-hospital, prehospitalization receipt of aspirin, echocardiography, coronary angiography, referral to cardiac rehabilitation, smoking cessation advice, dietary advice, and prescription on discharge of aspirin, P2Y12 inhibition, angiotensin converting enzyme inhibitor (ACEi)/angiotensin receptor blocker (ARB), beta-blocker, and statin. Conclusion The EORP NSTEMI Registry is an international, prospective registry of care and outcomes of patients treated for NSTEMI, which will provide unique insights into the contemporary management of hospitalised NSTEMI patients, compliance with ESC 2015 NSTEMI Guidelines, and identify potential barriers to optimal management of this common clinical presentation associated with significant morbidity and mortality