Bilateral stellate neuroretinitis revealing a pheochromocytoma

Neuroretinitis (NR) is an inflammatory disorder characterized by optic disc  edema and subsequent formation of a macular star. We present a case of a 33 year old woman patient admitted for a progressive bilateral visual loss since two weeks. Fundus examination showed bilateral stellate neuroretinitis. Physical examination revealed a malignant hypertension of 210/150mmHg. Magnetic resonance imaging identified a left suprarenal mass, whereas urinary catecholamine level was abnormally high which supported a diagnosis of pheochromocytoma.The patient underwent a laparoscopic left suprarenal adrenalectomy after successful control of blood pressure. histopathologic examination confirmed the diagnosis of pheochromocytoma. Visual acuity was restored and the retinal alterations disappeared 7 months after surgery

Comparative assessment of total phenolics content and in vitro antioxidant capacity variations of leaf extracts of Origanum grossii and Thymus pallidus

The objective of this research was to assess the efficacy of extracts derived from Origanum grossii and Thymus pallidus leaves, focusing on their inherent phenolic compounds with varying antioxidant processes. The extracts were obtained through the utilization of a Soxhlet apparatus for hot extraction. Several parameters including overall phenolic and flavonoid content, total antioxidant activity (TAC), ferric reduction capacity (FRAP), DPPH scavenging capacity, and ABTS capability were investigated. The total phenolic content ranged from 292.91±1.51 to 3.804±0.22 mg/g DW in oregano samples and from 284.3±1.78 to 3.435±0.23 mg/g DW in thyme fractions, employing gallic acid equivalents as the measurement unit. The sequence of extraction effectiveness, ranked from highest to lowest, was methanolic extracts > aqueous extracts > ethyl acetate extracts for both, oregano and thyme. Furthermore, the methanolic extracts displayed the greatest reducing and antiradical power, along with the highest total antioxidant capacities, for both plant species. These remarkable antioxidant properties of the extracts demonstrated a strong correlation with the levels of total phenols (TP) and total flavonoids (TF). Oregano and thyme leaves showcased promising antioxidant capacities, underscoring their potential as abundant sources of phenolic compounds with diverse antioxidant characteristics, thereby indicating their viability as natural preservatives

Nonlinear elliptic problem related to the Hardy inequality with singular term at the boundary

Let Ω ⊂ ℝNbe a bounded regular domain of ℝNand 1 &lt; p &lt; ∞. The paper is divided into two main parts. In the first part, we prove the following improved Hardy inequality for convex domains. Namely, for all [Formula: see text], we have [Formula: see text] where d(x) = dist (x, ∂Ω), [Formula: see text] and C is a positive constant depending only on p, N and Ω. The optimality of the exponent of the logarithmic term is also proved. In the second part, we consider the following class of elliptic problem [Formula: see text] where 0 &lt; q ≤ 2* - 1. We investigate the question of existence and nonexistence of positive solutions depending on the range of the exponent q.</jats:p

Antioxidant activities, total phenol an flavonoid contents of two Teucrium polium subspecies extracts

The soxhlet extracts of two subspecies from Moroccan Teucrium polium were examined for their antioxidant activities, total polyphenol and total flavonoids contents.The Antioxidant activities was evaluated in vitro spectrophotometrically using  four methods, such as ABTS+·, 1,1-diphenyl-2-picrylhydrzyl (DPPH·), ferric reducing antioxidant power and phosphomolybdenum assay. Total polyphenol and flavonoid contents  were measured using Folin-Ciocalteu test and aluminum chloride colorimetric method, respectively. The total phenol contents, flavonoids contents and antioxidant activities of T. polium subsp. polium extracts were higher than T. polium subsp. aurum. The phenols contents ranged from 112.27 to 4.38 mg GA E/ g dry extract. The total flavonoids varied between 174.57 and 40.42 mg RE/ g dry weight. The extract showed significant scavenging activity of  ABTS+·  and  DPPH·, with IC50 values ranging from 0.38 to 5 mg/ml and from 0.23 to 4.02 mg/ml, respectively. Moreover all extracts showed a good ferric reducing antioxidant power with EC50 values varying between 0.19 and 3.94 mg/ml. The total antioxidant capacity assay revealed that the water extract of T. polium subsp. aurum had a high activity with a value of 220 mg VitCE/g dry weight. The ethyl acetate extract has a weak antioxidant activity in the four tests. These results shows that Moroccan T. polium subspecies are a rich source of phenols and natural antioxidant compounds, which can be used as a natural food preservative

La baisse de la densité osseuse au cours des maladies inflammatoires chroniques de l’intestin : prévalence et facteurs de risqué

Introduction: La baisse de la densité minérale osseuse représente la principale manifestation osseuse décrite au cours des maladies inflammatoires chroniques de l'intestin. En Tunisie, très peu d'études ont rapportés sa prévalence et ses facteurs de risque. Le but de ce travail était de déterminer la prévalence de la perte osseuse au cours des maladies inflammatoires chroniques de l'intestin, et rechercher ses facteurs de risque. Méthodes: Patients et méthodes: étude ouverte transversale, réalisée de 2007 jusqu'à 2012. Résultats: 146 cas étaient colligés, dont 105 avaient une maladie de Crohn (71,9%) et 41 avaient une rectocolite hémorragique (28,1%). Il s'agissait de 62 hommes et 84 femmes. L'âge moyen était de 33,18 ans. La perte osseuse était trouvée chez 85 patients (58,2%). Il s'agissait d'une ostéopénie dans 57 cas et d'ostéoporose dans 28 cas. Les facteurs de risque de perte osseuse étaient une activité physique limitée  (p=0,013), un indice de masse corporel '20 kg/m2 (p=0,015), une maladie active (p=0,035), l'étendue de l'atteinte intestinale (p=0,006) et une dose cumulée de corticothérapie dépassant 4,5g de Prednisone (p=0,003). Conclusion: La déminéralisation osseuse est une complication fréquente mais non constante. Ceci justifie un dépistage précoce chez les patients à risque, qui pourront ainsi bénéficier d'un traitement substitutif.Key words: Maladie de Crohn, recto-colite hémorragique, densité minérale osseuse, ostéopénie, ostéoporos

The association of genetic predisposition to depressive symptoms with non-suicidal and suicidal self-Injuries

Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age\ua0=\ua042.4\ua0years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p\ua0=\ua00.008, explained variance ranging from 0.10 to 0.16\ua0%) and, less consistently, in suicide attempts (lowest p\ua0=\ua00.04, explained variance ranging from 0.12 to 0.23\ua0%). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI

Measuring loss aversion under ambiguity: a method to make prospect theory completely observable

We propose a simple, parameter-free method that, for the first time, makes it possible to completely observe Tversky and Kahneman’s (1992) prospect theory. While methods exist to measure event weighting and the utility for gains and losses separately, there was no method to measure loss aversion under ambiguity. Our method allows this and thereby it can measure prospect theory’s entire utility function. Consequently, we can properly identify properties of utility and perform new tests of prospect theory. We implemented our method in an experiment and obtained support for prospect theory. Utility was concave for gains and convex for losses and there was substantial loss aversion. Both utility and loss aversion were the same for risk and ambiguity, as assumed by prospect theory, and sign-comonotonic trade-off consistency, the central condition of prospect theory, held