805 research outputs found
Single side damage simulations and detection in beam-like structures
Beam-like structures are the most common components in real engineering, while single side damage is often encountered. In this study, a numerical analysis of single side damage in a free-free beam is analysed with three different finite element models; namely solid, shell and beam models for demonstrating their performance in simulating real structures. Similar to experiment, damage is introduced into one side of the beam, and natural frequencies are extracted from the simulations and compared with experimental and analytical results. Mode shapes are also analysed with modal assurance criterion. The results from simulations reveal a good performance of the three models in extracting natural frequencies, and solid model performs better than shell while shell model performs better than beam model under intact state. For damaged states, the natural frequencies captured from solid model show more sensitivity to damage severity than shell model and shell model performs similar to the beam model in distinguishing damage. The main contribution of this paper is to perform a comparison between three finite element models and experimental data as well as analytical solutions. The finite element results show a relatively well performanc
Međudjelovanje četiri-razinskog atoma u impulsnom svojstvenom stanju s jednomodnim poljem
We study the interaction between a four-level atom (ladder type) in a momentum eigenstate with a single mode cavity field in the presence of non-linearities of both the field and the intensity-dependent coupling. The constants of motion and the wave function for the atomic system have been obtained. Special attention is given to discuss some statistical aspects of the considered atomic system such as momentum increment, momentum diffusion and high-order squeezing. The influence of the Kerr-like medium and the intensity dependent coupling on the momentum increment and the high-order squeezing are investigated numerically. It is found that addition of these parameters has an important effect on both the momentum increment and the squeezing phenomenon.Proučavamo međudjelovanje četiri-razinskog atoma (poput ljestvi) u impulsnom svojstvenom stanju s jednomodnim poljem u rezonatoru, uz nelinearnosti polja i vezanja ovisnog o intenzitetu. Izveli smo stalnice gibanja valne funkcije atomskog sustava. Posebnu smo pažnju posvetili raspravi o statističkim odlikama razmatranog atomskog sustava, kao što su povećanje i difuzija impulsa i zbijanje višeg reda. Numerički smo istražili utjecaj Kerrovog sredstva i vezanja ovisnog o intenzitetu na povećanje impulsa i zbijanje višeg reda. Našli smo da dodavanje tih parametara ima snažan učinak na povećanje impulsa i pojavu zbijanja
Isogeometric analysis for functionally graded microplates based on modified couple stress theory
Analysis of static bending, free vibration and buckling behaviours of
functionally graded microplates is investigated in this study. The main idea is
to use the isogeometric analysis in associated with novel four-variable refined
plate theory and quasi-3D theory. More importantly, the modified couple stress
theory with only one material length scale parameter is employed to effectively
capture the size-dependent effects within the microplates. Meanwhile, the
quasi-3D theory which is constructed from a novel seventh-order shear
deformation refined plate theory with four unknowns is able to consider both
shear deformations and thickness stretching effect without requiring shear
correction factors. The NURBS-based isogeometric analysis is integrated to
exactly describe the geometry and approximately calculate the unknown fields
with higher-order derivative and continuity requirements. The convergence and
verification show the validity and efficiency of this proposed computational
approach in comparison with those existing in the literature. It is further
applied to study the static bending, free vibration and buckling responses of
rectangular and circular functionally graded microplates with various types of
boundary conditions. A number of investigations are also conducted to
illustrate the effects of the material length scale, material index, and
length-to-thickness ratios on the responses of the microplates.Comment: 57 pages, 14 figures, 18 table
Nitrate removal from water using UV-M/S2O42- advanced reduction process
In this work, a new process called advanced reduction process (ARP) was used for nitrate removal from water. This ARP process combines sodium dithionite as reducing agent with ultraviolet irradiation using medium pressure lamps (UV-M) as an activating method. Experimental results showed that UV-M/S2O42- process achieved almost complete removal of nitrate from aqueous solutions containing 25 mg NO3-/L using stoichiometric dose of dithionite of 68.8 mg/L at neutral pH conditions. Analysis of final products and material balance confirmed that NO3- ions were reduced to ammonium with formation of nitrite as intermediates in addition to the formation of small amounts of volatile species, mainly ammonia and nitrogen gas. Effects of certain experimental parameters including dithionite dose, initial pH, initial nitrate concentration, and UV light source on the kinetics and efficiency of nitrate reduction were evaluated. Increasing dithionite dose augmented the rate of nitrate reduction and enhanced the efficiency of ARP process. Dithionite doses higher than stoichiometric ratios led to complete removal of nitrate in shorter reaction time. UV-M/S2O42- process was found to be effective only under neutral pH or alkaline conditions, and its removal efficiency is negligible in acidic medium (pH < 4). Irradiation with UV-M was more effective than low pressure or narrow band lamps. These results can be attributed to the contribution of several mechanisms for nitrate reduction to ammonium. These include the following: direct photolysis, chemical reduction of nitrate dithionite, and mediated reduction of nitrate by free reducing radicals. © 2013 Islamic Azad University (IAU).Qatar National Research Fund (QNRF) - No. NPRP 4-1174-2-458
Global consortium for the classification of fungi and fungus-like taxa
The Global Consortium for the Classification of Fungi and fungus-like taxa is an international initiative of more than 550 mycologists to develop an electronic structure for the classification of these organisms. The members of the Consortium originate from 55 countries/regions worldwide, from a wide range of disciplines, and include senior, mid-career and early-career mycologists and plant pathologists. The Consortium will publish a biannual update of the Outline of Fungi and fungus-like taxa, to act as an international scheme for other scientists. Notes on all newly published taxa at or above the level of species will be prepared and published online on the Outline of Fungi website (https://www.outlineoffungi.org/), and these will be finally published in the biannual edition of the Outline of Fungi and fungus-like taxa. Comments on recent important taxonomic opinions on controversial topics will be included in the biannual outline. For example, ‘to promote a more stable taxonomy in Fusarium given the divergences over its generic delimitation’, or ‘are there too many genera in the Boletales?’ and even more importantly, ‘what should be done with the tremendously diverse ‘dark fungal taxa?’ There are undeniable differences in mycologists’ perceptions and opinions regarding species classification as well as the establishment of new species. Given the pluralistic nature of fungal taxonomy and its implications for species concepts and the nature of species, this consortium aims to provide a platform to better refine and stabilise fungal classification, taking into consideration views from different parties. In the future, a confidential voting system will be set up to gauge the opinions of all mycologists in the Consortium on important topics. The results of such surveys will be presented to the International Commission on the Taxonomy of Fungi (ICTF) and the Nomenclature Committee for Fungi (NCF) with opinions and percentages of votes for and against. Criticisms based on scientific evidence with regards to nomenclature, classifications, and taxonomic concepts will be welcomed, and any recommendations on specific taxonomic issues will also be encouraged; however, we will encourage professionally and ethically responsible criticisms of others’ work. This biannual ongoing project will provide an outlet for advances in various topics of fungal classification, nomenclature, and taxonomic concepts and lead to a community-agreed classification scheme for the fungi and fungus-like taxa. Interested parties should contact the lead author if they would like to be involved in future outlines
Toward Improved Outcomes for Patients With Lung Cancer Globally: The Essential Role of Radiology and Nuclear Medicine
PURPOSE
Key to achieving better population-based outcomes for patients with lung cancer is the improvement of medical imaging and nuclear medicine infrastructure globally. This paper aims to outline why and spark relevant health systems strengthening.
METHODS
The paper synthesizes the global lung cancer landscape, imaging referral guidelines (including resource-stratified ones), the reliance of TNM staging upon imaging, relevant multinational health technology assessments, and precisely how treatment selection and in turn patient outcomes hinge upon imaging findings. The final discussion presents data on current global gaps in both diagnostics (including imaging) and therapies and how, informed by such data, improved population-based outcomes are tangible through strategic planning.
RESULTS
Imaging findings are central to appropriate lung cancer patient management and can variably lead to life-prolonging interventions and/or to life-enhancing palliative measures. Early-stage lung cancer can be treated with curative intent but, unfortunately, most patients with lung cancer still present at advanced stages and many patients lack access to both diagnostics and therapies. Furthermore, half of lung cancer cases occur in low- and middle-income countries. The role of medical imaging and nuclear medicine in lung cancer management, as outlined herein, may help inform strategic planning.
CONCLUSION
Lung cancer is the number one cancer killer worldwide. The essential role that medical imaging and nuclear medicine play in early diagnosis and disease staging cannot be overstated, pivotal in selecting the many patients for whom measurably improved outcomes are attainable. Prevention synergized with patient-centered, compassionate, high-quality lung cancer management provision mandate that strategic population-based planning, including universal health coverage strategies, should extend well beyond the scope of disease prevention to include both curative and noncurative treatment options for the millions afflicted with lung cancer
Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment
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