Heterogeneous Water and Energy End-Uses and Implications for Residential Water and Energy Conservation and Management

The thesis develops an integrated approach to model heterogeneous household water and energy end-uses and their linkages. The approach considers variations in behavioral and technological water-and-energy-use factors that affect indoor residential water- and energy-use in the U.S. Here, we use a recent, large, national, disaggregated household dataset of potable hot and cold water end-uses collected from eleven cities. We also use national energy data to estimate heterogeneous energy-uses for household water appliances including toilets, showers, faucets, clothes-washers, and dishwashers. First, probability distributions of water- and energy-use factors are identified, correlated, and compared among study sites. Then Monte Carlo simulations are used to calculate probability distributions for estimated households’ water-and-energy-uses. Finally, linear regressions are used to find the relative effects of water and energy factors on household energy-use. Results show that water and energy distributions among households are heavily skewed, with the largest 14.6% of the users consuming 30.5% and 33.1% of water and energy, respectively. Water heater dispense temperature followed by faucet flowrate have the highest relative effect on household energy-use and should be targeted to reduce household energy use. The approach improves prior homogenous and deterministic water-energy models and can help utilities select and size cost-effective collaborative water and energy conservation actions

A Data Model to Manage Data for Water Resources Systems Modeling

Current practices to identify, organize, analyze, and serve data to water resources systems models are typically model and dataset-specific. Data are stored in different formats, described with different vocabularies, and require manual, model-specific, and time-intensive manipulations to find, organize, compare, and then serve to models. This paper presents the Water Management Data Model (WaMDaM) implemented in a relational database. WaMDaM uses contextual metadata, controlled vocabularies, and supporting software tools to organize and store water management data from multiple sources and models and allow users to more easily interact with its database. Five use cases use thirteen datasets and models focused in the Bear River Watershed, United States to show how a user can identify, compare, and choose from multiple types of data, networks, and scenario elements then serve data to models. The database design is flexible and scalable to accommodate new datasets, models, and associated components, attributes, scenarios, and metadata

Implications of Data Sampling Resolution on Water Use Simulation, End-Use Disaggregation, And Demand Management

Understanding the tradeoff between the information of high-resolution water use data and the costs of smart meters to collect data with sub-minute resolution is crucial to inform smart meter networks. To explore this tradeoff, we first present STREaM, a STochastic Residential water End-use Model that generates synthetic water end-use time series with 10-s and progressively coarser sampling resolutions. Second, we apply a comparative framework to STREaM output and assess the impact of data sampling resolution on end-use disaggregation, post meter leak detection, peak demand estimation, data storage, and meter availability. Our findings show that increased sampling resolution allows more accurate end-use disaggregation, prompt water leakage detection, and accurate and timely estimates of peak demand. Simultaneously, data storage requirements and limited product availability mean most large-scale, commercial smart metering deployments sense data with hourly, daily, or coarser sampling frequencies. Overall, this work provides insights for further research and commercial deployment of smart water meters

First Report of Leishmania tropica from a Classical Focus of L. major in North-Sinai, Egypt

This is the publisher's version, also available electronically from http://www.ajtmh.org/content/81/2/213.long.Cutaneous leishmaniasis (CL) is prevalent in the Egyptian Sinai Peninsula and previous research has consistently documented the etiologic agent to be Leishmania major. We report the first isolation of Leishmania tropica from human cases of CL in a Northern Sinai community bordering Palestine. Parasite culturing, real-time polymerase chain reaction (PCR), gene sequencing, and restriction fragment length polymorphism (RFLP) analyses indicate CL cases in this community were caused by either L. major or L. tropica (three cases each). Two wild-caught rodents (Gerbillus pyramidum floweri) were infected with L. tropica. Phlebotomus papatasi sand flies were found harboring L. major, however only non-infected individuals of Phlebotomus sergenti, a vector for L. tropica, were caught. Patients with L. tropica had not traveled from the region in over a year, suggesting these cases are autochthonous. This scenario is consistent with an incursion of L. tropica from bordering countries and raises concerns about expansion of this parasite further into Egypt

Assessing Data Availability and Research Reproducibility in Hydrology and Water Resources

There is broad interest to improve the reproducibility of published research. We developed a survey tool to assess the availability of digital research artifacts published alongside peer-reviewed journal articles (e.g. data, models, code, directions for use) and reproducibility of article results. We used the tool to assess 360 of the 1,989 articles published by six hydrology and water resources journals in 2017. Like studies from other fields, we reproduced results for only a small fraction of articles (1.6% of tested articles) using their available artifacts. We estimated, with 95% confidence, that results might be reproduced for only 0.6% to 6.8% of all 1,989 articles. Unlike prior studies, the survey tool identified key bottlenecks to making work more reproducible. Bottlenecks include: only some digital artifacts available (44% of articles), no directions (89%), or all artifacts available but results not reproducible (5%). The tool (or extensions) can help authors, journals, funders, and institutions to self-assess manuscripts, provide feedback to improve reproducibility, and recognize and reward reproducible articles as examples for others

Anticancer property of hexane extract of Suaeda fruticose plant leaves against different cancer cell lines

Purpose: To evaluate the bioactivity of hexane extract of S. fruticosa leaves against the cancer cell lines HepG2, MCF-7, and HCT-116, and to determine the chemical composition-function relationship. Methods: Using the liquid-liquid extraction method, the nonpolarL constituent compounds were isolated from the leaves. The cytotoxicity of the hexane extract was evaluated using an SRB assay. Mechanism of action was verified by observing the appearance of apoptotic bodies using fluorescence microscopy, while anti-proliferative activity was assayed via flow cytometry. Results: The results revealed that secondary metabolites in the hexane extract demonstrated the highest cytotoxicity, and thus anticancer activity, against HCT-116 cells, with an IC50 of 17.15 ± 0.78 mg/mL. The presence of apoptotic bodies indicate an ability to induce apoptosis. Flow cytometry results suggest that the secondary metabolites stalled the cell cycle at the G0/G1 phase. Conclusion: The results indicate that S. fruticosa hexane extract may be considered a potential new source of the anti-cancer compound, momilactone B. Keywords: Anticancer, Apoptosis, Colon Cancer, Liver cancer, Breast cancer, Liquid chromatography–mass spectrometry, Suaeda fruticose, Momilactone

Water-Use Data in the United States: Challenges and Future Directions

In the United States, greater attention has been given to developing water supplies and quantifying available waters than determining who uses water, how much they withdraw and consume, and how and where water use occurs. As water supplies are stressed due to an increasingly variable climate, changing land-use, and growing water needs, greater consideration of the demand side of the water balance equation is essential. Data about the spatial and temporal aspects of water use for different purposes are now critical to long-term water supply planning and resource management. We detail the current state of water-use data, the major stakeholders involved in their collection and applications, and the challenges in obtaining high-quality nationally consistent data applicable to a range of scales and purposes. Opportunities to improve access, use, and sharing of water-use data are outlined. We cast a vision for a world-class national water-use data product that is accessible, timely, and spatially detailed. Our vision will leverage the strengths of existing local, state, and federal agencies to facilitate rapid and informed decision-making, modeling, and science for water resources. To inform future decision-making regarding water supplies and uses, we must coordinate efforts to substantially improve our capacity to collect, model, and disseminate water-use data

Intraoperative endomanometric laparoscopic Nissen fundoplication improves postoperative outcomes in large sliding hiatus hernia with severe gastroesophageal reflux disease. A retrospective cohort study

Background: Laparoscopic Nissen Fundoplication (LNF) is the gold standard surgical intervention for gastroesophageal reflux disease (GERD). LNF can be followed by recurrent symptoms or complications affecting patient satisfaction. The aim of this study is to assess the value of the intraoperative endomanometric evaluation of esophagogastric competence and pressure combined with LNF in patients with large sliding hiatus hernia (> 5 cm) with severe GERD (DeMeester score >100). Materials and methods: This is a retrospective, multicenter cohort study. Baseline characteristics, postoperative dysphagia and gas bloat syndrome, recurrent symptoms, and satisfaction were collected from a prospectively maintained database. Outcomes analyzed included recurrent reflux symptoms, postoperative side effects, and satisfaction with surgery. Results: 360 patients were stratified into endomanometric LNF (180 patients, LNF+) and LNF alone (180 patients, LNF). Recurrent heartburn (3.9% vs. 8.3%) and recurrent regurgitation (2.2% vs. 5%) showed a lower incidence in the LNF+ group (P=0.012). Postoperative score III recurrent heartburn and score III regurgitations occurred in 0% vs. 3.3% and 0% vs. 2.8% cases in the LNF+ and LNF groups, respectively (P=0.005). Postoperative persistent dysphagia and gas bloat syndrome occurred in 1.75% vs. 5.6% and 0% vs. 3.9% of patients (P=0.001). Score III postoperative persistent dysphagia was 0% vs. 2.8% in the two groups (P=0.007). There was no redo surgery for dysphagia after LNF+. Patient satisfaction at the end of the study was 93.3% vs. 86.7% in both cohorts, respectively (P=0.05). Conclusions: Intraoperative high-resolution manometry (HRM) and endoscopic were feasible in all patients, and the outcomes were favorable from an effectiveness and safety standpoint