Recent Advances in Nanomaterials Development for Nanomedicine and Cancer

Cancer is considered one of the leading causes of death, with a growing number of cases worldwide. However, the early diagnosis and efficient therapy of cancer have remained a critical challenge. The emergence of nanomedicine has opened up a promising window to address the drawbacks of cancer detection and treatment. A wide range of engineered nanomaterials and nanoplatforms with different shapes, sizes, and composition has been developed for various biomedical applications. Nanomaterials have been increasingly used in various applications in bioimaging, diagnosis, and therapy of cancers. Recently, numerous multifunctional and smart nanoparticles with the ability of simultaneous diagnosis and targeted cancer therapy have been reported. The multidisciplinary attempts led to the development of several exciting clinically approved nanotherapeutics. The nanobased materials and devices have also been used extensively to develop point-of-care and highly sensitive methods of cancer detection. In this review article, the most significant achievements and latest advances in the nanomaterials development for cancer nanomedicine are critically discussed. In addition, the future perspectives of this field are evaluated

Optimization of the basal medium for improving production and secretion of taxanes from suspension cell culture of <it>Taxus baccata</it> L

<p>Abstract</p> <p>Background and purpose of the study</p> <p>Taxol is one of the most effective anticancer drugs that isolated from <it>Taxus</it> sp. due to the slow growth of <it>Taxus</it> trees and low concentration of Taxol in the tissues, the biotechnological approaches especially plant cell culture have been considered to produce Taxol in commercial scale.</p> <p>Methods</p> <p>We investigated the effects of basal medium type used in culture media on production of Taxol and other taxane compounds from cell suspension culture of <it>T. baccata</it> L. Briefly, five commonly basal media including Gamborg, Murashige and Skoog, Woody Plant, Schenk and Hildebrandt, and Driver and Kuniyuki medium were used for preparing separate suspension culture media. The intra- and extra-cellular yields of taxanes were analyzed by using HPLC after 21 days period of culturing.</p> <p>Results</p> <p>The yields of taxanes were significantly different for the cultures prepared by different basal media. Moreover, the effects of basal medium on the yield of products differed for varius taxane compounds. Maximum yields of Baccatin III (10.03 mgl^-1) and 10-deacetyl baccatin III (4.2 mgl^-1) were achieved from the DKW basal media, but the yield of Taxol was maximum (16.58 mgl^-1) in the WPM basal media. Furthermore, the secretion of taxanes from the cells into medium was also considerably affected by the type of basal medium. The maximum extra-cellular yield of Taxol (7.81 mgl^-1), Baccatin III (5.0 mgl^-1), and 10-deacetyl baccatin III (1.45 mgl^-1) were also obtained by using DKW basal medium that were significantly higher than those obtained from other culture media.</p