Anti-Caspr 2 Antibody Encephalitis: A Case Report

Encephalitis is a term denoted to Inflammation in the brain which can be due to infection, autoimmunity, or can be a part of a paraneoplastic phenomenon with malignancy. Anti-CASPR 2 antibody encephalitis is a rare form of encephalitis that can be associated with malignancy, paraneoplastic phenomenon or can be an autoimmune disease. We present a case of a young boy who presented with new onset seizures and altered sensorium and was diagnosed with anti-CASPR 2 antibody encephalitis. Anti-CASPR 2 Antibody Encephalitis is a rare form of encephalitis which due to its great diverse presentation should be kept in the differential diagnosis of conditions like limbic encephalitis

Association of Hyperuricemia with Ischemic Stroke in Adult Population

Background and Objective: Stroke is the second most prevalent cause of dementia, the third biggest cause of mortality, and the top cause of disability globally. Hyperuricemia is frequently seen in patients with vascular risk factors. The objective of this study was to determine the association of hyperuricemia with ischemic stroke in adult patients presenting to neurology department of a tertiary care hospital. Methods:This was a case-control study of 200 patients, 100 patients with stroke and 100 unmatched controls were accessed for vascular risk factors and hyperuricemia. The setting was Pakistan Institute of Medical Sciences, Islamabad and study duration was six months (August 2021 to February 2022). Odds Ratio (OR) was calculated to measure the association of ischemic stroke with hyperuricemia for each group. OR\u3e1 was taken as significant. Results:Out of 100 patients in the case group, 25 (25%) had hyperuricemia. Whereas, out of 100 patients in the control group, 07 (7%) had hyperuricemia. The P-value was 0.001. Odds ratio was 4.42. Out of 100 patients in the case group, the median patient age was 35 and the highest patient age was 75. The mean age, symptom duration, and uric acid level were 55.216.24 years, 20.588.97 hours, and 7.212.24 mg/dl, respectively. The control group had 100 patients with an average age of 35 and a maximum age of 75. The median age was 52.48 years old, and the median uric acid level was 2.48 mg/dl. Conclusion:Hyperuricemia is linked positively to occurrence of ischemic stroke as evidenced by the positive odds ratio. Further studies need to be done to investigate whether uric acid lowering therapy is useful in preventing stroke or reducing mortality