Nutrition Able: A Lecture-based Intervention to Promote Nutritional Literacy About Protein Intake in Women

Sport performance is influenced by sport-specific requirements for body composition. One major predictor of body composition is protein intake. Higher protein intake tends to cause leaner body composition relative to lower protein intake, especially during caloric deficit. In Bexar County, ~72% of the adult population is overweight/obese and 15.5% are diabetic. This suggests that high protein diet could be a high leverage option in the San Antonio population for optimizing body composition for sport performance. Furthermore, late life sporting activity and protein intake is a primary method for mitigating sarcopenia, osteoporosis, fractures, and accidental death in post-menopausal women. PURPOSE: This project, called Nutrition Able, aims to teach Bexar County middle school and high school students in food-scarce areas how to read a nutrition label with their health in mind through hands-on, in-person, lectures in Southside and Southwest ISD classrooms, emphasizing the importance of dietary protein. METHODS: Pairs of health professions students give lectures and administer health literacy assessments. Before each lecture, we inform students that they will be taking an anonymous non-graded survey. The survey consists of 7 multiple-choice questions regarding calories, macronutrients, calories per serving, macronutrient content, fiber, protein, and diabetes/obesity prevention. No assistance interpreting the questions is provided. We also collect the following demographic data at the students’ discretion: height, weight, sex, grade, age, and family history of obesity and diabetes (FH). Following the pre-survey, our lecture is given. Afterwards, an identical post-survey is administered. RESULTS: To date, 11 lectures reaching 432 students between 6th and 12th grade have been given. Overall, there were large improvements in pre-/post-survey scores (2.47 vs. 3.31, P\u3c\u3c\u3c.05), with improvements in all seven questions, median (2 vs. 3), and mode (2 vs. 4). For 6 out of the 7 questions on the survey, male and female students had no significant difference in post-survey rates of correct responses. The question which did reach statistical significance was the question about protein’s health benefits. Women scored lower on this question in both pre- (25% vs. 37%, P=.015) and post-surveys (36% vs. 49%, P=.01), with no difference in the improvement in score. CONCLUSION: Nutrition Able is effective at improving health literacy broadly but has room to improve in emphasizing protein’s efficacy as a tool improving for sport performance and body composition in women. Long-standing myths that lifting weights and eating protein will drastically change your appearance often disincentivize women from engaging in important health promoting behaviors like resistance training and eating a high protein diet, putting them at risk for post-menopausal sarcopenia, osteoporosis, and debilitating fractures. Future talks will further emphasize that protein is an important nutritional factor for all demographics, especially women

Aetiology and use of antibiotics in pregnancy-related infections: results of the WHO Global Maternal Sepsis Study (GLOSS), 1-week inception cohort

Background Pregnancy-related infections are important contributors to maternal sepsis and mortality. We aimed to describe clinical, microbiological characteristics and use of antibiotics by source of infection and country income, among hospitalized women with suspected or confirmed pregnancy-related infections. Methods We used data from WHO Global Maternal Sepsis Study (GLOSS) on maternal infections in hospitalized women, in 52 low-middle- and high-income countries conducted between November 28th and December 4th, 2017, to describe the frequencies and medians of maternal demographic, obstetric, and clinical characteristics and outcomes, methods of infection diagnosis and causative pathogens, of single source pregnancy-related infection, other than breast, and initial use of therapeutic antibiotics. We included 1456 women. Results We found infections of the genital (n = 745/1456, 51.2%) and the urinary tracts (UTI) (n = 531/1456, 36.5%) to be the most frequent. UTI (n = 339/531, 63.8%) and post-caesarean skin and soft tissue infections (SSTI) (n = 99/180, 55.0%) were the sources with more culture samples taken and microbiological confirmations. Escherichia coli was the major uropathogen (n = 103/118, 87.3%) and Staphylococcus aureus (n = 21/44, 47.7%) was the commonest pathogen in SSTI. For 13.1% (n = 191) of women, antibiotics were not prescribed on the same day of infection suspicion. Cephalosporins (n = 283/531, 53.3%) were the commonest antibiotic class prescribed for UTI, while metronidazole (n = 303/925, 32.8%) was the most prescribed for all other sources. Ceftriaxone with metronidazole was the commonest combination for the genital tract (n = 98/745, 13.2%) and SSTI (n = 22/180, 12.2%). Metronidazole (n = 137/235, 58.3%) was the most prescribed antibiotic in low-income countries while cephalosporins and co-amoxiclav (n = 129/186, 69.4%) were more commonly prescribed in high-income countries. Conclusions Differences in antibiotics used across countries could be due to availability, local guidelines, prescribing culture, cost, and access to microbiology laboratory, despite having found similar sources and pathogens as previous studies. Better dissemination of recommendations in line with antimicrobial stewardship programmes might improve antibiotic prescription

Stratospheric aerosol - Observations, processes, and impact on climate

Interest in stratospheric aerosol and its role in climate have increased over the last decade due to the observed increase in stratospheric aerosol since 2000 and the potential for changes in the sulfur cycle induced by climate change. This review provides an overview about the advances in stratospheric aerosol research since the last comprehensive assessment of stratospheric aerosol was published in 2006. A crucial development since 2006 is the substantial improvement in the agreement between in situ and space-based inferences of stratospheric aerosol properties during volcanically quiescent periods. Furthermore, new measurement systems and techniques, both in situ and space based, have been developed for measuring physical aerosol properties with greater accuracy and for characterizing aerosol composition. However, these changes induce challenges to constructing a long-term stratospheric aerosol climatology. Currently, changes in stratospheric aerosol levels less than 20% cannot be confidently quantified. The volcanic signals tend to mask any nonvolcanically driven change, making them difficult to understand. While the role of carbonyl sulfide as a substantial and relatively constant source of stratospheric sulfur has been confirmed by new observations and model simulations, large uncertainties remain with respect to the contribution from anthropogenic sulfur dioxide emissions. New evidence has been provided that stratospheric aerosol can also contain small amounts of nonsulfate matter such as black carbon and organics. Chemistry-climate models have substantially increased in quantity and sophistication. In many models the implementation of stratospheric aerosol processes is coupled to radiation and/or stratospheric chemistry modules to account for relevant feedback processes

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Persistent organic pollutants in air from Asia, Africa, Latin America, and the Pacific

In support of the United Nations Environment Programme (UNEP) global monitoring plan under the Stockholm Convention concentrations of persistent organic pollutants (POPs) were determined during two years in air from 42 countries in Asia, Africa, Latin America, and the Pacific by using polyurethane foams installed in passive samplers. The compounds included were polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenylethers (PBDEs), one polybrominated biphenyl and hexabromocyclododecane (HBCD) diastereomers. Total-DDT and PCBs were the highest in concentrations in about 50% of the samples, which shows their high persistency. Total DDT in air from the Solomon Islands ranged from 200 to 600 ng/polyurethane foam disk (PUF). However, at most locations, a decreasing trend is observed for PCBs, DDT and most other OCPs. Patterns varied per country with e.g. elevated dieldrin in air from Barbados and chlordane in air from the Philippines. A number of OCPs, such as heptachlor and its epoxides, some other chlordanes, mirex and toxaphene have decreased down to almost undetectable levels. PBB153 was hardly found and penta and octa–mix related PBDEs were also relatively low at most locations. HBCD and the decabromodiphenylether were more prominent at many locations and may even still increase. To draw more holistic conclusions more colder climate countries should be included in this program

Assessing the Projected Changes in European Air Stagnation due to Climate Change

Air pollution is a major environmental threat to human health. Pollutants can reach extreme levels in the lower atmosphere when weather conditions permit. As pollutant concentrations depend on scales and processes that are not fully represented in current global circulation models (GCMs), and it is often too computationally expensive to run models with atmospheric chemistry and aerosol processes, air stagnation is often used as a proxy for pollution events with particular success in Europe. However, the variables required to identify air stagnation can have biases in GCM output, which adds uncertainty to projected trends in air stagnation. Here, the representation of air stagnation in GCMs is assessed for Europe in the historical period and in end-of-century projections based on a high-emission scenario using three methods for identifying air stagnation. The monthly frequency of stagnation during summer and autumn is projected to increase with climate change when stagnation is identified by a well-established index. However, this increase is not present when air-stagnation frequency is estimated using a statistical model based on the synoptic- to large-scale atmospheric circulation. This implies that the projected increases in air stagnation are not driven by an increase in frequency or severity of large-scale circulation events that are conducive to stagnation. Indeed, projected changes to the atmospheric circulation in GCMs, in particular a reduction in atmospheric block frequency, would suggest a reduction in future air stagnation. Additional analyses indicate that the projected increases in stagnation frequency follow the trend toward more frequent dry days, which is apparently unrelated to the large-scale drivers of air stagnation.Peer reviewe

BFA 2014-2015 senior show catalogue

All artwork and installation images from B.F.A. exhibitions in the Earl & Virginia Green Art Gallery at Biola University. All images provided by the artists; used by permission. Book design by John Griffith. RUIN//REPAIR - interdisciplinary - Angelica Nicolle Abalos Seventy Times - interdisciplinary - Jacob Adent Dust & Dust - interdisciplinary - Katya Austin Fine/Motion - design - Aaron Cantleberry Somethings - interdisciplinary - Hannah Efron An Efflorescence - interdisciplinary - Lauren Higgins Tactile Spectrum - design - Melinda Kaun Even in Memory - photography - Alyssa Martin Super Fine - design - Haley Martin Emergence - interdisciplinary - Randi Martinez Return - interdisciplinary - Eddie Moon Laundry - interdisciplinary - David Rhee Round 2 - painting - Julia Smith Excavation - design - Katelyn Seitz Embrace - painting - Amanda Upp Burn / Grow / Repeat - design - Amy Van Vlear Nuestras Historias [Shared stories] - interdisciplinary - Josue Abraham Luna The Exchange - design - Carol Martinez “Dear Child” - interdisciplinary - David Wahlmanhttps://digitalcommons.biola.edu/exhibit-catalogs/1004/thumbnail.jp

Aetiology and use of antibiotics in pregnancy-related infections: results of the WHO Global Maternal Sepsis Study (GLOSS), 1-week inception cohort.

BackgroundPregnancy-related infections are important contributors to maternal sepsis and mortality. We aimed to describe clinical, microbiological characteristics and use of antibiotics by source of infection and country income, among hospitalized women with suspected or confirmed pregnancy-related infections.MethodsWe used data from WHO Global Maternal Sepsis Study (GLOSS) on maternal infections in hospitalized women, in 52 low-middle- and high-income countries conducted between November 28th and December 4th, 2017, to describe the frequencies and medians of maternal demographic, obstetric, and clinical characteristics and outcomes, methods of infection diagnosis and causative pathogens, of single source pregnancy-related infection, other than breast, and initial use of therapeutic antibiotics. We included 1456 women.ResultsWe found infections of the genital (n = 745/1456, 51.2%) and the urinary tracts (UTI) (n = 531/1456, 36.5%) to be the most frequent. UTI (n = 339/531, 63.8%) and post-caesarean skin and soft tissue infections (SSTI) (n = 99/180, 55.0%) were the sources with more culture samples taken and microbiological confirmations. Escherichia coli was the major uropathogen (n = 103/118, 87.3%) and Staphylococcus aureus (n = 21/44, 47.7%) was the commonest pathogen in SSTI. For 13.1% (n = 191) of women, antibiotics were not prescribed on the same day of infection suspicion. Cephalosporins (n = 283/531, 53.3%) were the commonest antibiotic class prescribed for UTI, while metronidazole (n = 303/925, 32.8%) was the most prescribed for all other sources. Ceftriaxone with metronidazole was the commonest combination for the genital tract (n = 98/745, 13.2%) and SSTI (n = 22/180, 12.2%). Metronidazole (n = 137/235, 58.3%) was the most prescribed antibiotic in low-income countries while cephalosporins and co-amoxiclav (n = 129/186, 69.4%) were more commonly prescribed in high-income countries.ConclusionsDifferences in antibiotics used across countries could be due to availability, local guidelines, prescribing culture, cost, and access to microbiology laboratory, despite having found similar sources and pathogens as previous studies. Better dissemination of recommendations in line with antimicrobial stewardship programmes might improve antibiotic prescription