Fostering Work Engagement through State and Trait Trust: Evidence from Irish University Research Centres

The central aim of this research was to examine the impact of state and trait trust on employees’ levels of work engagement. More specifically, in this study, the three forms of state trust - trust in top management, trust in direct supervisor and trust in team members, as well as trait trust (trust propensity) - were hypothesised as antecedents of work engagement. Furthermore, it was proposed that organizational identification, affective commitment to the supervisor and team psychological safety will mediate the effects of trust in top management, trust in direct supervisor and trust in team members on work engagement respectively. Finally, the relationship of work engagement with a variety of work outcomes such as, in-role job performance, innovative work behaviour, feedback seeking, error communication and organizational commitment, as well as the mediating effects of learning goal orientation on these relationships were investigated. Using survey data from 152 research scientists, drawn from six university science research centres operating in Ireland, the hypotheses were tested through hierarchical multiple regression analyses. The results of this study showed that as hypothesised, organizational identification, affective commitment to the supervisor, and team psychological safety fully mediated the effects of trust in top management, trust in direct supervisor, and trust in team members on work engagement respectively. Moreover, the findings of this study indicated that trust propensity was also positively and significantly related to work engagement. Additionally, it was found that learning goal orientation partially mediated the effects of work engagement on in-role job performance, innovative work behaviour, feedback seeking and error communication, while it did not mediate the relationship between work engagement and organizational commitment. On the basis of these findings, recommendations were made for the management of research centres and for future research directions

Intracranial intricacies: Comprehensive analysis of rare skull base meningiomas—A single‐center case series

Key Clinical Message This study paper's main goal is to report rare cases of skull base meningiomas that exemplify the complexities of diagnosis, therapy, and postoperative care. By describing these rare cases, we hope to advance knowledge of the clinical signs, difficulties, and prognoses of skull base meningiomas in a challenging anatomical setting. In the posterior cranial fossa, our investigation reveals a unique example of skull base meningioma that involved numerous cranial nerves and complex vasculature. A variety of visual abnormalities were present in the patient's clinical presentations, highlighting the wide range of symptoms that these tumors might cause depending on their precise positions. These cases highlight the critical importance of preoperative imaging, including high‐resolution MRI and angiography, as well as the diagnostic difficulties these tumors pertain. By reporting these instances, our research adds to the body of knowledge about skull base meningiomas and offers insightful information about the nuances of their therapies. Our findings highlight the importance of individualized treatment plans, interdisciplinary cooperation, and the demand for continued study to better comprehend these convoluted tumors. Such studies are essential for advancing our knowledge of these enigmatic tumors, guiding clinical judgment, and eventually improving patient outcomes. These findings are important because they can fill information gaps, improve treatment plans, and encourage additional research in neuro‐oncology. Abstract This study presents a series of three rare cases of skull base meningiomas, emphasizing the complexities in diagnosis, treatment, and postoperative care. The patients' clinical presentations and imaging highlighted the diverse symptoms and challenges associated with these tumors, found in intricate anatomical locations. The cases underscore the crucial role of preoperative high‐resolution imaging and angiography in diagnostic accuracy. Surgical intervention, guided by a multidisciplinary approach, is pivotal in managing these demanding cases. Histopathological examinations confirmed atypical meningiomas. The postoperative phases involved meticulous care to ensure optimal recovery and functional outcomes. Our findings contribute to the understanding of skull base meningiomas, emphasizing the need for personalized treatment plans and ongoing research to improve patient outcomes in neuro‐oncology

National cervical cancer burden estimation through systematic review and analysis of publicly available data in Pakistan

Abstract Background Cervical cancer is a major cause of cancer-related deaths among women worldwide. Paucity of data on cervical cancer burden in countries like Pakistan hamper requisite resource allocation. Objective To estimate the burden of cervical cancer in Pakistan using available data sources. Methods We performed a systematic review to identify relevant data on Pakistan between 1995 to 2022. Study data identified through the systematic review that provided enough information to allow age specific incidence rates and age standardized incidence rates (ASIR) calculations for cervical cancer were merged. Population at risk estimates were derived and adjusted for important variables in the care-seeking pathway. The calculated ASIRs were applied to 2020 population estimates to estimate the number of cervical cancer cases in Pakistan. Results A total of 13 studies reported ASIRs for cervical cancer for Pakistan. Among the studies selected, the Karachi Cancer Registry reported the highest disease burden estimates for all reported time periods: 1995–1997 ASIR = 6.81, 1998–2002 ASIR = 7.47, and 2017–2019 ASIR = 6.02 per 100,000 women. Using data from Karachi, Punjab and Pakistan Atomic Energy Cancer Registries from 2015–2019, we derived an unadjusted ASIR for cervical cancer of 4.16 per 100,000 women (95% UI 3.28, 5.28). Varying model assumptions produced adjusted ASIRs ranging from 5.2 to 8.4 per 100,000 women. We derived an adjusted ASIR of 7.60, (95% UI 5.98, 10.01) and estimated 6166 (95% UI 4833, 8305) new cases of cervical cancer per year. Conclusion The estimated cervical cancer burden in Pakistan is higher than the WHO target. Estimates are sensitive to health seeking behavior, and appropriate physician diagnostic intervention, factors that are relevant to the case of cervical cancer, a stigmatized disease in a low-lower middle income country setting. These estimates make the case for approaching cervical cancer elimination through a multi-pronged strategy