Reduced Incidence of Slowly Progressive Heymann Nephritis in Rats Immunized With a Modified Vaccination Technique

A slowly progressive Heymann nephritis (SPHN) was induced in three groups of rats by weekly injections of a chemically modified renal tubular antigen in an aqueous medium. A control group of rats received the chemically unmodified version of the antigen in an aqueous solution. One group of SPHN rats were pre- and post-treated with weekly injections of IC made up of rKF3 and rarKF3 IgM antibody at antigen excess (MIC) (immune complexes [ICs] containing sonicated ultracentrifuged [u/c] rat kidney fraction 3 [rKF3] antigen and IgM antibodies specific against the antigen, at slight antigen excess). One group of SPHN rats were post-treated with MIC 3 weeks after the induction of the disease and one group of SPHN animals received no treatment. The control group of rats received pre- and post-treatment with sonicated u/c rKF3

Correcting autoimmune anomalies in autoimmune disorders by immunological means, employing the modified vaccination technique

Our research group has developed a new vaccination technique in experimental animals that has the potential of correcting autoimmune anomalies in humans such as autoimmune disorders, cancer, and chronic infections, both prophylactically and therapeutically. The vaccination method is called Modified Vaccination Technique (MVT). The MVT necessitates the introduction of a purified target antigen (ag) and a specific antibody (ab) against the target ag in the form of immune complex (IC) to evoke the desired immune response outcome by ab information transfer in the injected recipient. The injected IC produces the same class of ab in the host, with the same specificity against the target ag, as resides in the inoculum. The MVT promises to provide a means of upregulating beneficial immune events and downregulating undesirable immune responses in individuals, thereby re-establishing normalcy/tolerance to self. © 2009 Elsevier B.V. All rights reserved.link_to_subscribed_fulltex

Modified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders

Public health can be protected most effectively through vaccination programmes. However, while presently available vaccination techniques protects the individual by provoking immune responses against exogenous antigens (ags), such as those associated with certain bacteria and viruses, they cannot protect against or treat mishaps caused by endogenous ag. Recently, Barabas and colleagues have developed a new vaccination method, called modified vaccination technique (MVT), which allows the presentation of disease causing agents in such a way as to initiate and maintain desired immune response outcomes even in the context of mishaps associated with endogenous ag. For example, in an experimental autoimmune kidney disease, the MVT downregulated/terminated pathogenic immune responses that were causing morphological and functional changes of the kidney. The MVT promises, with appropriate case-specific modifications, both preventative and curative applications for ailments, such as endogenous ag initiated mishaps (i.e. autoimmune diseases and cancer) and diseases caused by chronic infection, that are presently only treatable with drugs. To achieve specific immune responses, purified components of the vaccine (ag and antibodies) must be produced and assembled into immune complexes having the potential of inducing predetermined corrective immune response outcomes. © 2010 Blackwell Publishing Ltd.link_to_subscribed_fulltex

Preventing And Treating Chronic Disorders Using The Modified Vaccination Technique.

It Is Anticipated That The Ultimate Solution For The Prevention And Termination Of Autoimmune Disorders Will Be Based On Somehow Manipulating The Cells Of The Immune System To Attain Antigen (Ag) Specific Downregulation And Termination. In The Last Few Years We Have Developed A New Vaccination Technique That We Call "Modified Vaccination Technique" (Mvt). It Has With Equal Effectiveness Both Prevented And Terminated Autoimmune Disease Causing Events In An Experimental Autoimmune Kidney Disease Model. We Expect That Our Technique Will Be Similarly Applicable To The Specific Treatment And Cure Of Numerous Other Chronic Disorders Presently Treated Only By Drugs. The Vaccine Is Composed Of Two Components, An Ag And A Specific Antibody Against It. When These Are Combined At Slight Ag Excess They Constitute A Vaccine Which Is Capable Of Treating Chronic Ailments By Redirecting Immune Response Outcomes In The Vaccinated Host. Both Components, Like Drugs, Will Have To Be Produced Ex Vivo In Order To Maintain Uniformity, Safety, Efficacy, And Specificity.link_to_subscribed_fulltex

The role of autoimmunologists in investigating and treating autoimmune disorders

The role of an autoimmunologist is to investigate and cultivate knowledge of normal and abnormal immune responses against self, which includes developing practical know-how to manipulate autoimmune activity and direct positive autoimmune outcomes. Where a subject develops an abnormal immune response directed against normal self, resulting in an autoimmune disease, the specialist should be able to diagnose the problem and institute an appropriate treatment. Obversely, where a subject lacks an immune response against cells bearing antigens that are abnormal or not quite self, i.e., cancer cells, the specialist should ideally be able to institute a specific cancer cell killing regimen. Essentially there are two beneficial and two harmful aspects of autoimmunity autoimmunologists should be familiar with. The beneficial aspects are the immune responses that assist in the clearance of cellular breakdown products and the elimination of cancer cells. The harmful aspects consist of immune responses, or lack thereof, that manifest in autoimmune disorders, i.e., autoimmune diseases and cancer. Recent medical discoveries, especially the modified vaccination technique developed by the Barabas research group, show great promise in both preventing and curing autoimmune disorders by utilizing the immune system's natural abilities to re-establish normal health. © 2010 Elsevier B.V.link_to_subscribed_fulltex