31 research outputs found
A meta‐analysis on small intestinal bacterial overgrowth in patients with different subtypes of irritable bowel syndrome
Three months of weekly rifapentine plus isoniazid for latent tuberculosis treatment in solid organ transplant candidates
Self-Glycolipids Modulate Dendritic Cells Changing the Cytokine Profiles of Committed Autoreactive T Cells
Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Gene Expression in Response to Static Magnetism in Cultured Rat Hippocampal Neurons
Structural basis for modulation of Kv4 K + channels by auxiliary KChIP subunits
KChIPs coassemble with pore-forming Kv4 α subunits to form a native complex in the brain and heart and regulate the expression and gating properties of Kv4 K + channels, but the mechanisms underlying these processes are unknown. Here we report a co-crystal structure of the complex of human Kv4.3 N-terminus and KChIP1 at a 3.2-Å resolution. The structure reveals a unique clamping action of the complex, in which a single KChIP1 molecule, as a monomer, laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner, forming an octamer. The proximal N-terminal peptide of Kv4.3 is sequestered by its binding to an elongated groove on the surface of KChIP1, which is indispensable for the modulation of Kv4.3 by KChIP1, and the same KChIP1 molecule binds to an adjacent T1 domain to stabilize the tetrameric Kv4.3 channels. Taken together with biochemical and functional data, our findings provide a structural basis for the modulation of Kv4 by KChIPs. © 2007 Nature Publishing Group.link_to_subscribed_fulltex