Inhaled foreign bodies: children with peanut in airway

Foreign body aspiration is a common problem in young children. Many patients present after a significant delay despite having a witnessed choking event. Moreover, their presentations may mimic other common respiratory problems like pneumonia or asthma. It is extremely important to be attentive to history taking and clinical signs that may indicate early bronchoscopy to confirm the diagnosis.published_or_final_versio

Pulmonary sequestration in an infant

Pulmonary sequestration is a congenital anomaly of lung parenchyma without a normal connection to the tracheobronchial tree and an anomalous systemic arterial supply. We report an 11-month-old boy with extralobar pulmonary sequestration. Magnetic resonance angiogram identified the arterial supply from aorta and venous drainage to azygous vein. Various imaging techniques for diagnosis of pulmonary sequestration are discussed.link_to_OA_fulltex

Therapy of recurrent high grade gliomas with surgery, and autologous mitogen activated IL-2 stimulated killer (MAK) Lymphocytes: I. Enhancement of MAK lytic activity and cytokine production by PHA and clinical use of PHA

Nineteen patients with recurrent high grade gliomas were treated in a phase I/II trial with aggressive debulking of the tumor, mitogen activated IL-2 stimulated peripheral blood lymphocytes (MAK cells), and rIL-2. Phytohemagglutin (PHA) was introduced into the tumor site in 16 patients prior to implanting MAK cells and IL-2 in an attempt to trigger more effective lysis of the tumor in vivo. In vitro both TNF bioactivity and cytolytic activity of long term cultured MAK (LMAK) cells were dramatically enhanced by adding PHA to the cultures of these activated PBL. Three of eleven patients (27%) had a decrease in size of the enhancing lesion on CT and/or MRI. Seven (37%) patients clinically improved. Median survival after therapy was 30 weeks. PHA was shown to be safe in vivo and more effective than IL-2 triggering enhanced effector function in vitro