3 research outputs found
Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cells
In this review we start with a historical perspective beginning with the early morphological work done almost 50Â years ago. The importance of these pioneering studies is underscored by our brief summary of the key questions addressed by subsequent research into the mechanism of secretion. We then highlight important advances in our understanding of the formation and maturation of neuroendocrine secretory granules, first using in vitro reconstitution systems, then most recently biochemical approaches, and finally genetic manipulations in vitro and in vivo
Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes
Mucolipidosis II mice, as well as patients with this disorder, exhibit extensive vacuolization of their exocrine gland cells. We now demonstrate that the vacuoles are enlarged autolysosomes containing undigested cytoplasmic material that accumulate secondary
to deficient lysosomal degradative function. A model to explain this finding is proposed