Pancreas Burkitt primary lymphoma in pediatric age

We present an the case of an eight-year-old Portuguese boy with no history of traveling, admitted with non-specific abdominal pain. An analytic study revealed high levels of lipase and amylase. Ultrasound, abdominal computerized tomography (CT), and an abdominal magnetic resonance imaging (MRI), were performed. The imaging findings are suggestive of a pancreatic tumor which is an extremely rare entity in children. A biopsy was performed by opened surgery and identified a Burkitt lymphoma.info:eu-repo/semantics/publishedVersio

Ecologia microbiana do solo.

Fatores abióticos que afetam os microrganismos; Temperatura do solo; pH do solo; Fontes de energia e substratos orgânicos; Nutrientes minerais; Práticas de manejo e cultivo dos solos; Interação entre microrganismos; Interações microbianas de importância para a produção agrícola.bitstream/item/35904/1/Doc164.pd

Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria

"Published online 17 February 2021"Polyphenols have been extensively exploited in the biomedical field because of their wide range of bioactive properties and historical use as traditional medicines. They typically present antioxidant, antimicrobial, antiamyloidogenic, and/or antitumor activities. In particular, cork water extracts and their components, have been previously reported to present antioxidant and antiamyloidogenic properties. On the basis of this knowledge, we tested cork water extract (CWE), cork water enriched extract (CWE-E), vescalagin/castalagin (two of the main polyphenols present in CWE and CWE-E) for their antibacterial activity against four bacterial strains, namely, methicillin-resistant Staphylococcus epidermidis (MRSE), Staphylococcus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), and Pseudomonas aeruginosa (PA). Vescalagin and castalagin presented bactericidal activity against all the tested bacterial strains, in particular toward the methicillin-resistant ones, i.e., MRSA and MRSE, as well as the ability to inhibit the formation of biofilms and to disrupt preformed ones. Moreover, vescalagin/castalagin seem to modulate the normal assembly of the peptidoglycans at the bacteria surface, promoting the disruption of their cell wall, leading to bacterial cell death. We also demonstrate that vescalagin/castalagin can be loaded into alginate hydrogels to generate antibacterial biomaterials that are not toxic to eukaryotic cells.We acknowledge the financial support from the EC (FORECAST 668983 and MEPHOS 872648). A.R.A. acknowledges the “Programa Operacional Regional do Norte”, “Fundo Social Europeu”, and Norte2020 TERM&SC, for her PhD grant (NORTE-08-5369-FSE-000044)

Proteomics for Biomarker Discovery for Diagnosis and Prognosis of Kidney Transplantation Rejection

Renal transplantation is currently the treatment of choice for end-stage kidney disease, enabling a quality of life superior to dialysis. Despite this, all transplanted patients are at risk of allograft rejection processes. The gold-standard diagnosis of graft rejection, based on histological analysis of kidney biopsy, is prone to sampling errors and carries high costs and risks associated with such invasive procedures. Furthermore, the routine clinical monitoring, based on urine volume, proteinuria, and serum creatinine, usually only detects alterations after graft histologic damage and does not differentiate between the diverse etiologies. Therefore, there is an urgent need for new biomarkers enabling to predict, with high sensitivity and specificity, the rejection processes and the underlying mechanisms obtained from minimally invasive procedures to be implemented in routine clinical surveillance. These new biomarkers should also detect the rejection processes as early as possible, ideally before the 78 clinical outputs, while enabling balanced immunotherapy in order to minimize rejections and reducing the high toxicities associated with these drugs. Proteomics of biofluids, collected through non-invasive or minimally invasive analysis, e.g., blood or urine, present inherent characteristics that may provide biomarker candidates. The current manuscript reviews biofluids proteomics toward biomarkers discovery that specifically identify subclinical, acute, and chronic immune rejection processes while allowing for the discrimination between cell-mediated or antibody-mediated processes. In time, these biomarkers will lead to patient risk stratification, monitoring, and personalized and more efficient immunotherapies toward higher graft survival and patient quality of life.info:eu-repo/semantics/publishedVersio

Efeito de banhos terapêuticos com formalina sobre indicadores de estresse em tambaqui.

O objetivo deste trabalho foi avaliar o efeito de concentrações terapêuticas de formalina na homeostase de tambaqui (Colossoma macropomum Cuvier 1818) por meio de índices fisiológicos

Microscopia eletrônica de varredura da interação Alternaria solani - tomateiro suscetível e resistente.

Objetivando analisar os eventos iniciais das interações A. solani - L. hirsutum var. glabratum e A. solani - L. esculentum ev. Miller, será realizado um trabalho utilizando processamento para microscopia eletrônica de varredura.bitstream/CPAA-2009-09/9291/1/IT_6_99.pd