8 research outputs found
CK1 activates minus-end–directed transport of membrane organelles along microtubules
This study shows that the signal transduction pathway responsible for the initiation of minus-end–directed movement of membrane-bounded pigment granules in melanophores involves sequential activation of protein phosphatase 2A and casein kinase 1 and that this activation correlates with increased phosphorylation of the dynein intermediate chain
Carbachol-mediated pigment granule dispersion in retinal pigment epithelium requires Ca2+ and calcineurin
Recruitment of dynein to late endosomes and lysosomes through light intermediate chains
How cytoplasmic dynein is recruited to diverse organelles remains incompletely understood. Using the first subcellular localization of LIC isoforms, along with RNAi, RILP, and dynactin dominant negatives, the LIC subunits are found to recruit dynein specifically to components of the late endocytic pathway through a dynactin-independent mechanism