3 research outputs found
Formation of C-C bonds via iridium-catalyzed hydrogenation and transfer hydrogenation
The formation of C鈥揅 bonds via catalytic hydrogenation and transfer hydrogenation enables carbonyl and imine addition in the absence of stoichiometric organometallic reagents. In this review, iridium-catalyzed C鈥揅 bond-forming hydrogenations and transfer hydrogenations are surveyed. These processes encompass selective, atom-economic methods for the vinylation and allylation of carbonyl compounds and imines. Notably, under transfer hydrogenation conditions, alcohol dehydrogenation drives reductive generation of organoiridium nucleophiles, enabling carbonyl addition from the aldehyde or alcohol oxidation level. In the latter case, hydrogen exchange between alcohols and 蟺-unsaturated reactants generates electrophile鈥搉ucleophile pairs en route to products of hydro-hydroxyalkylation, representing a direct method for the functionalization of carbinol C鈥揌 bonds