15 research outputs found
Chest Wall Resection for Adult Soft Tissue Sarcomas and Chondrosarcomas: Analysis of Prognostic Factors
Background: Wide resection with tumor-free margins is necessary in soft-tissue sarcomas to minimize local recurrence and to contribute to long-term survival. Information about treatment outcome and prognostic factors of adult sarcoma requiring chest wall resection (CWR) is limited. Methods: Sixty consecutive patients were retrospectively studied for overall survival (OS), local recurrence-free survival (LRFS), and disease-free survival (DFS). Twenty-one prognostic factors regarding survival were analyzed by univariate analysis using the Kaplan-Meier method and the log-rank test. Results: With a median survival of 2.5 years, the OS was 46% (33%) at 5 (10) years. The LRFS was 64% at 5 and 10 years, and the DFS was 30% and 25% at 5 and 10 years. At the end of the study period, 26 patients (43%) were alive, of which 20 patients (33%) had no evidence of disease and 40 patients (67%) had no chest wall recurrence. In the group of 9 patients with a radiation-induced soft-tissue sarcoma, the median survival was 8 months. Favorable outcome in univariate analysis in OS and LRFS applied for the low-grade sarcoma, bone invasion, and sternal resection. For OS only, age below 60 years and no radiotherapy were significant factors contributing to an improved survival. CWR was considered radical (R0) at the pathological examination in 43 patients. There were 52 patients with an uneventful recovery. There was one postoperative death. Conclusions: CWR for soft-tissue sarcoma is a safe surgical procedure with low morbidity and a mortality rate of less than 1%. With proper patient selection acceptable survival can be reached in a large group of patients. Care must be given to patients with radiation-induced soft-tissue sarcoma who have a significantly worse prognosis
Three‐dimensional custom‐made carbon‐fiber prosthesis for sternal reconstruction after sarcoma resection
A Case of Invasive Thymoma Projecting into the Lumen of Superior Vena Cava Without Intimal Invasion
Osteosarcoma in the Anterior Chest Wall That Developed 20 Years After Postoperative Radiotherapy for Breast Cancer
Tumors of the Chest Wall
Primary tumors of the chest wall are uncommon.
Chest wall tumors, whether malignant or benign,are classified as primary or secondary (metastatic).The most common benign tumors are osteochondromas and chondromas. The most common malignant chest wall tumors are sarcomas.
Most primary tumors originate in the bones or muscles of the chest wall, though they can also arise from nerves and vessels. Less than half
of malignant chest wall tumors are primary. Secondary tumors originate elsewhere in the body and spread (metastasize) to the chest wall.
The most frequent secondary tumors of the chest wall spread from primary breast and lung cancer. In fact, they can either locally extend to the chest wall, or metastasize to it. Furthermore, other tumors that are not unfrequently spread to the pleura include those originating from ovary, kidney, uterus, head and neck, and testis.
Therefore, almost all secondary tumors are malignant. Most chest wall tumors found in children are primary, while most found in adults are
secondary . It is often difficult to make an accurate presurgical diagnosis and differentiate benign from malignant tumors. Most patients with primary chest wall tumor receive surgical biopsy or radical surgical resection
Reconstrução da parede torácica nos defeitos adquiridos
Acquired chest wall defects present a challenging problem for thoracic surgeons. Many of such defects can be repaired with the use of local and regional musculocutaneous flaps, but larger defects compromising skeletal structure require increasingly sophisticated reconstructive techniques. The following discussion will review the options for repair acquired chest wall defects based in literature. The authors searched the Pubmed (www.pubmed.com) and found citations from January 1996 to February 2008. By reading the titles and the abstracts most of the citations were discharged because they focused in congenital chest wall defects or were cases report. However, many papers were found describing the outcome of large series of patients with acquired chest wall deformities. A review of recent literature shows that the repair of chest wall defects with soft tissues, if possible, remains the treatment of choice. Large chest wall defects require skeletal reconstruction to prevent paradoxical respiration. The selection of the most appropriate flap is primary dictated by the location and the size of the defect. It is important to transfer tissue with good vitality, so understanding the vascular supply is imperative. Autogenous grafts have been used in the past for skeletal reconstruction but a combination of synthetic materials with musculocutaneous flaps has been used lately. Based in the literature, the use of prosthetic material in chest wall reconstruction does not significantly increases the risk of wound infection